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OBJECTIVE Patients with latent autoimmune diabetes in adults (LADA) express autoantibodies against the 65-kDa isoform of GAD (GADA). Intervention with recombinant human GAD65 formulated with aluminium hydroxide (GAD-alum) given twice subcutaneously to LADA patients at intervals of 4 weeks was safe and did not compromise beta-cell function in a Phase II clinical trial. GADA affinity has been shown
Background: Frontotemporal dementia (FTD) is recognised as a clinically and morphologically heterogeneous group of interrelated neurodegenerative conditions. One of the subtypes within this disease spectrum is the behavioural variant FTD (bvFTD). This is known to be a varied disorder with a mixture of tau-positive and tau-negative underlying pathologies. The other subtypes include semantic dementi
Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen i världen bland kvinnor och bara i Sverige insjuknar varje år runt 7000 personer. Vi vet att omkring 10-15% av fallen troligen beror på ärftliga faktorer och det har under senare tid gjorts stora insatser för att klargöra exakt vilka arvsanlag som har betydelse för utveckling av sjukdomen. Under början av 90-talet identifieradeHereditary breast cancer constitutes a considerable fraction of the total number of breast cancer cases occurring each year. Up until recently very few breast cancer predisposing genes were known, but many new common polymorphisms contributing to increased cancer susceptibility are continuously being identified. This thesis has focused on familial breast cancer and identifying as well as investi
Applications of microchannel heat sinks for dissipating heat loads have received great attention. Wavy channels are recognized to be an alternative cooling technology to enhance the heat transfer, and are successfully applied in heat exchangers. In this article, three kinds of liquid-cooling double-layer microchannel heat sinks, such as a rectangular straight microchannel heat sink, a parallel-flo
Background: Metabolic syndrome (MetS) remains a controversial entity. Specific clusters of MetS components - rather than MetS per se - are associated with accelerated arterial ageing and with cardiovascular (CV) events. To investigate whether the distribution of clusters of MetS components differed cross-culturally, we studied 34,821 subjects from 12 cohorts from 10 European countries and one coho
The polymeric immunoglobulin receptor (pIgR) is a key component of the mucosal immune system that mediates epithelial transcytosis of immunoglobulins. High pIgR expression has been reported to correlate with a less aggressive tumour phenotype and an improved prognosis in several human cancer types. Here, we examined the expression and prognostic significance of pIgR in pancreatic and periampullary
Background: Topical negative pressure (TNP), widely used in wound therapy, is known to stimulate wound edge blood flow, granulation tissue formation, angiogenesis, and revascularization. We have previously shown that application of a TNP of -50 mmHg to the myocardium significantly increases microvascular blood flow in the underlying tissue. We have also shown that a myocardial TNP levels between -
Osteoclast activity and the fine balance between bone formation and resorption is affected by inflammatory factors such as cytokines and T lymphocyte activity, mediated by major histocompatibility complex (MHC) molecules, in turn regulated by the MHC class II transactivator (MHC2TA). We investigated the effect of functional polymorphisms in the MHC2TA gene (CIITA), and two additional genes; C-type
Background: The metabolic syndrome describes a cluster of cardiovascular risk factors that frequently appear together. Its diagnosis is generally based on several well-recognized indicators in clinical practice, such as abdominal obesity, elevated triglycerides, reduced high-density lipoprotein, raised blood pressure, and elevated fasting plasma glucose. Today, decisive importance must be attached
Candelaria pacifica is formally described. It is currently known from North and South America and Europe. The species is characterized by a small, lobate thallus with soredia formed on the lobe tips and along the margins. It has been confused with C. concolor in Europe and North America, but differs in having 8-spored asci and in lacking a lower cortex. Candelaria vulgaris, the type species of the
Planning for future needs has traditionally been considered to be restricted to human cognition. Although recent studies on great ape and corvid cognition challenge this belief, the phylogenesis of human planning remains largely unknown. The complex skill for future planning has not yet been satisfactorily established in any other extant primate species than our own. In humans, planning for future
Purpose: The purpose of this work was to evaluate the visibility of simulated lesions in 2D digital mammography (DM) and breast tomosynthesis (BT) images of patients. Methods: Images of the same women were acquired on both a DM system (Mammomat Novation, Siemens Healthcare, Erlangen, Germany) and a BT prototype system adapted from the same type of DM system. Using the geometrical properties of the
Background: Different foods can modulate cardiometabolic risk factors in persons already affected by metabolic alterations. The objective of this study was to assess, in healthy overweight individuals, the impact of a diet combining multiple functional concepts on risk markers associated with cardiometabolic diseases (CMD). Methods: Fourty-four healthy women and men (50-73 y.o, BMI 25-33, fasting
Autochthonous blockfield mantles may indicate alpine surfaces that have not been glacially eroded. These surfaces may therefore serve as markers against which to determine Quaternary erosion volumes in adjacent glacially eroded sectors. To explore these potential utilities, chemical weathering features, erosion rates, and regolith residence durations of mountain blockfields are investigated in the
BACKGROUND: Floods are the most frequent and devastating type of natural disaster worldwide, causing unprecedented deaths, diseases, and destruction of property and crops. Flooding has a greater impact in developing countries due to lack of sufficient disaster management structures and a lack of economic resources. OBJECTIVE: This study was conducted with the aim of contributing to the knowledge b
Microsoft Word - Brevmall, svenska utlysning ASG.doc Pu fendor f ins t i tutet Lund 2016-09-30 Inbjudan att inkomma med förslag till ”Advanced study group” vid Pufendorfinstitutet, 2017 - 2018 Pufendorfinstitutet inbjuder nu till att ansöka om att bilda ”Advanced study group”. Hur föreslår man en Advanced study group för 2017 - 2018? Ett förslag till ”Advanced study group” skall inkomma till insti
https://www.pi.lu.se/sites/pi.lu.se/files/utlysning_asg_2017-2018_sve.pdf - 2026-07-18
Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development ARTICLE Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development Katarína Tiklová1, Åsa K. Björklund 2, Laura Lahti1, Alessandro Fiorenzano3, Sara Nolbrant3, Linda Gillberg1, Nikolaos Volakakis1, Chika Yokota4, Markus M. Hilscher4, Thoma
https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/tiklova.pdf - 2026-07-18
Reversion of β-Cell Autoimmunity Changes Risk of Type 1 Diabetes: TEDDY Study Reversion of b-Cell Autoimmunity Changes Risk of Type 1 Diabetes: TEDDY Study DOI: 10.2337/dc16-0181 OBJECTIVE b-Cell autoantibodies are a feature of the preclinical phase of type 1 diabetes. Here, we asked how frequently they revert in a cohort of children at risk for type 1 diabetes and whether reversion has any effect
https://www.teddy.lu.se/sites/teddy.lu.se/files/06212016_679_58_vehik_diab_care_2016_0.pdf - 2026-07-18
In yet another alarming development in Syria, the waters of the Euphrates River have declined to critically low levels in 2021. The unprecedented low water levels of the Euphrates put nearly 5.5 million Syrians at risk as they depend on the Euphrates basin for drinking water and agricultural production. This study examines the phenomenon of water shortages in the Euphrates River whilst utilising t
