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This paper investigates how early career academics interpret and respond to institutional demands structured by projectification. Developing a ‘frame analytic’ approach, it explores projectification as a process constituted at the level of meaning-making. Building on 35 in-depth interviews with fixed-term scholars in political science and history, the findings show that respondents jointly referre
This comparative study delves into the intricate challenges surrounding stigma within active labor market programs (ALMPs) and its implications for work, wellbeing, and social policy. In both Sweden and Australia, employers exhibit reluctance to draw from this candidate pool for recruitment. Understanding employers' reasons for not utilising ALMP candidates, their expectations from candidates, and
Background and Non–HDL-C provides an estimate of lipid-associated risk and is a secondary treatment target after myocardial infarction Aims (MI). The aim was to study the relationship between non–HDL-C levels after MI and risk of adverse outcomes. Methods From the SWEDEHEART registry, 56 262 patients with MI were included. Outcomes were major adverse cardiovascular event (MACE: death, MI, and isch
Background Fidanacogene elaparvovec, an adeno-associated virus (AAV) gene-therapy vector for hemophilia B containing a high-activity human factor IX variant (FIX-R338L/FIX-Padua), was associated with sustained factor IX activity in a phase 1-2a study. Methods We conducted a phase 3 open-label study of fidanacogene elaparvovec at a dose of 5×1011 vector genome copies per kilogram of body weight. Me
OBJECTIVES: The efficacy of long-term opioid therapy (LTOT) in treating patients with chronic non-cancer pain (CnCP) is questionable, and the potential risks of adverse effects are well established. The aims were as follows: (1) compare characteristics in patients exposed to LTOT vs non-exposed. (2) Regarding opioid-exposed patients, describe characteristics of patients with risk factors for opioi
Enzymes are conformationally dynamic, and their dynamical properties play an important role in regulating their specificity and evolvability. In this context, substantial attention has been paid to the role of ligand-gated conformational changes in enzyme catalysis; however, such studies have focused on tremendously proficient enzymes such as triosephosphate isomerase and orotidine 5'-monophosphat
We report a series of molecular dynamics (MD) simulations of up to a microsecond combined simulation time designed to probe epigenetically modified DNA sequences. More specifically, by monitoring the effects of methylation and hydroxymethylation of cytosine in different DNA sequences, we show, for the first time, that DNA epigenetic modifications change the molecule's dynamical landscape, increasi
Carbon capture and storage technologies (CCS) are being discussed and tested in different countries to reduce industrial emissions. Public opinion about industrial CCS (iCCS) can be a key factor in whether it will be implemented. Yet, measuring public acceptance of CCS is a challenge: on the one hand, the use of CCS is the subject of intense and controversial political debate. On the other hand, a
Nuclear factor-E2-related factor 2 (NRF2) is a transcription factor that activates the antioxidant cellular defense in response to oxidative stress, leading to neuroprotective effects in Parkinson's disease (PD) models. We have previously shown that Angiotensin II (AngII) induces an increase in reactive oxygen species (ROS) via AngII receptor type 1 and NADPH oxidase (NOX), which may activate the
Background: Recent studies indicate the need to examine how the gut microbiota–brain axis is implicated in pain, sensory reactivity and gastro-intestinal symptoms in autism spectrum disorder (ASD), but no scale exists that assesses all these constructs simultaneously. Methods: We created a pool of 100 items based on the real-world experience of autistic people, and a multidisciplinary team and sta
How do political parties function abroad? How do political parties mobilize overseas supporters during elections? This chapter focuses on the cases of the Justice and Development Party (AKP) and the Peoples’ Democratic Party (HDP), the two most successful Turkish political parties among emigrants. It compares their distinct organisational structures and mobilisation techniques when seeking to reac
When it comes to random walk on the integers Z, the arguably first step of generalization beyond simple random walk is the class of one-sidedly continuous random walk, where the stepsize in only one direction is bounded by 1. Moreover, the time until state 0 is hit by left-continuous random walk on Z has a direct connection to the total progeny in branching processes. In this article, the probabil
BACKGROUND: In 2013, it was discovered that a subset of the population in Ronneby, Sweden was exposed to high levels of perfluorinated compounds (PFAS) from drinking water that had been provided by the local Brantafors waterworks and was contaminated by fire-fighting foam from a nearby airport. The start and time-course of population exposures are not known.OBJECTIVE: To investigate the start of P
Background and Aims The long-term outcomes of percutaneous coronary intervention (PCI) vs. coronary artery bypass grafting (CABG) in patients with non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel disease remain debated. Methods The Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies registry
Global climate change is one of the greatest environmental threats facing humanity and it is affecting every country on every continent. Recent evidence confirms a close liaison between climate change induced hazards and the built environment, as the built environment demonstrates a high fragility and vulnerability to hazardous situations. The impact of climate change is particularly pertinent to
Alzheimer’s disease, the most common form of dementia, is characterized by progressive cognitive decline and the accumulation of amyloid-beta (Aβ) and tau neurofibrillary tangle (NFT) pathology. The medial temporal lobe (MTL) is one of the earliest sites of NFT pathology, crucial for memory functioning, and is made up of cytoarchitectonic and functionally different subregions. These subregions are
BACKGROUND: Malignancies of the liver and bile ducts are associated with high recurrence rates after surgery and poor prognosis when disseminated. Medical treatment has been improved in recent years, with chemotherapy, targeted therapy and checkpoint inhibitors offering opportunities to influence the course of the diseases. Many patients do not benefit from treatment, however, and predictive and p
Current trends aim at improving the surface integrity of aerospace Ni-based superalloys by reducing the temperature rise in the cutting zone in order to minimize tool wear, as well as reducing the thermally induced tensile residual stresses on the machined surface. The manufacturing industry is also driven by developing high performance sustainable machining processes. Cryogenic machining (CM) usi
Low-energy-electron emission from resonant Auger final states via intermolecular Coulombic decay (RA-ICD) has previously been described as a promising scenario for controlling radiation damage for medical purposes, but it has so far only been observed in prototypical atomic and molecular van der Waals dimers and clusters. Here, we report the experimental observation of RA-ICD in an aqueous solutio
