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Sertraline and paroxetine are frequently prescribed SSRIs for long-term treatment of major depression. Nevertheless, continuous follow-ups of drug concentrations prevailing in patients during the whole treatment period are not available. Hence, in a large phase IV clinical trial, a total of 353 patients with major depression were enrolled for a 6-month comparison of sertraline (50-150 mg daily) an

Tumor development requires angiogenesis and anti-angiogenic therapies have been introduced in the treatment of cancer. In this context, heparan sulfate proteoglycans (HSPGs) emerge as interesting targets, owing to their function as co-receptors of major, pro-angiogenic factors. Accordingly, previous studies have suggested anti-tumor effects of heparin, i.e. over-sulfated HS, and various heparin mi

Purpose: Within the construction business pricing is traditionally done at current account. The purpose of this report is to investigate why pricing levels are low within the construction consultant industry in comparison to other consultant industries, as well as to examine what affects the choice of pricing models. In addition to this the report aims to analyze pricing models used today and to d

Herein, we present a case of severe immune-related adverse events (irAEs), myocarditis with myositis, and myasthenia gravis overlap syndrome (IM3OS) in a patient receiving an immune checkpoint inhibitor (ICI), as adjuvant therapy after surgery for muscle-invasive bladder cancer. An 80-year-old woman who had undergone a total cystectomy for bladder cancer presented with ptosis, diplopia, and paraly

Group A Streptococcus (GAS) causes extensive global morbidity and rising rates of invasive disease, for which clinical outcomes remain poor despite antibiotic treatment of susceptible strains. This limitation of current therapy underscores the need for alternative or adjunctive approaches. Antibody-based interventions represent a promising but underexplored strategy. Historically, the streptococca

This study investigated the presence of microplastics (MPs, >5 μm to <2 mm) in biofertilizers and estimated their mass input to Swedish agricultural soils. Collective samples from representative biogas facilities were analyzed using optical microscopy and optical photothermal infrared (O-PTIR) spectroscopy, with selected MPs examined by scanning electron microscopy (SEM). The highest MPs concentra

Background: L-DOPA-induced dyskinesia is attributed to opposite activity changes mediated by D1 and D2 dopamine receptors in the two striatal output pathways. Whereas the causal role of direct-pathway D1 receptors is well established, the specific involvement of indirect-pathway D2 receptors in dopaminergic dyskinesias has remained elusive. Objectives: We used conditional knockout approaches in mi

This book was conceived in the context of a workshop at the Lund University Malmö Theatre Academy, where we used our bodies to create patterns based on prompts such as if the work we do imagines sustainability more in terms of harmony or more in terms of conflict, or how we orient ourselves on a continuum of past, [present] and future. Important to note is that the patterns were ever-changing, not

Staphylococcus aureus remains one of the most elusive targets in bacterial vaccinology, primarily due to its complex immune evasion strategies and the phenomenon of immune imprinting. Despite decades of research and numerous clinical trials, no vaccine has demonstrated protective efficacy in humans. This review examines the underlying reasons for these failures and proposes a rational, integrati

Cell type annotation remains a critical bottleneck, with current methods often inaccurate and requiring extensive manual validation, particularly in disease contexts. While large language models (LLMs) show promise, they can be unreliable due to hallucinations. We developed CyteType, a multi-agent framework that generates competing hypotheses grounded in full expression data and study context, val

The BCR::ABL1 tyrosine kinase inhibitors (TKIs) in CML represent a paradigm for molecularly targeted therapy. However, clinical outcomes - rate/depth of response, treatment-free remission (TFR), progression to blast crisis (BC) - and adverse events vary among patients. While additional somatic mutations have been invoked to explain varying clinical outcomes, we here propose a complementary perspec

The Editor-in-Chief has retracted this article because Fig. 1 and its legend contained data that was published without the owner’s permission or the patient’s consent. Figure 1 has now been removed. Jesper Heldrup, Stefan Schwartz, Etienne Chatelut, Miriam Hwang do not agree to this retraction. Archie Bleyer did not state explicitly whether they agree ot this retraction. Brooke Bernhardt agrees to

Background: The aim of heart transplantation is prolonged survival and improved quality of life. Chronic pain is a common and distressing symptom after heart transplantation. To our knowledge, there are no person-centred interventions aimed at chronic pain and symptom distress after heart transplantation. The aim was to assess the feasibility and acceptability of systematic, person-centred symptom

Grön infrastruktur för bevarande av biologisk mångfald Grön infrastruktur för bevarande av biologisk mångfald BECC POLICY BRIEF | 07 ·  2020 BECC POLICY BRIEF | 07 ·  2020 Grön infrastruktur för bevarande av biologisk mångfald MARIA VON POST, Centrum för miljö- och klimatforskning, Lunds universitet JOHAN EKROOS, Centrum för miljö- och klimatforskning, Lunds universitet JOHANNA ALKAN OLSSON, Centr

https://www.cec.lu.se/sites/cec.lu.se/files/gron_infrastruktur.pdf - 2026-07-19

2 Revised Chapter 13 A.Hetzler ! 1! Chapter 13 “Framing Work Injury/Sickness in a Changing Welfare State – Naming and Blaming” Antoinette Hetzler, Lund University, Sweden “My views were completely disregarded and I was forced, despite my protests, to accept my work situation.” (F 64 year old, teacher, 0480) “I was ordered to work with this student and I told the principal that I could not do it. I

https://www.soc.lu.se/en/sites/soc.lu.se.en/files/chapter_13_a.hetzler.pdf - 2026-07-19

SIMP45 FINAL 210702 1 Version 1.0 – March 2021 GRADUATE SCHOOL PROFILE COURSES SIMP45 Introduction to Middle Eastern Studies AUTUMN 2021 2 1. WELCOME SIMP45 INTRODUCTION TO MIDDLE EASTERN STUDIES Contact info Graduate School e-mail: master@sam.lu.se Home page: graduateschool.sam.lu.se Facebook: tinyurl.com/LUgradschoolFB Student Union Home page: samvetet.org Lund University Home page: http://lundu

https://www.graduateschool.sam.lu.se/sites/graduateschool.sam.lu.se/files/2021-07/SIMP45%20FINAL%20210702.pdf - 2026-07-19

untitled \\jciprod01\productn\H\HLI\55-1\HLI105.txt unknown Seq: 1 29-JAN-14 10:15 Volume 55, Number 1, Winter 2014 Rule of Law in Afghanistan: Enabling a Constitutional Framework for Local Accountability Carol Wang* Rule of law practitioners have defined rule of law as a way to achieve several objectives. Three com- monly cited objectives are that rule of law should: 1. hold the governing powers

https://rwi.lu.se/wp-content/uploads/2024/11/Carol-Wang.pdf - 2026-07-19

In this article, we explore the production of socio-cultural values around blue-green solutions (BGS) through the perspective of care. We explore how values and preferences are formed through the complexity of everyday life engagements in a BGS environment. The data come from a questionnaire answered by 328 households in the neighborhood of Augustenborg in Malmö, Sweden. The questionnaire collects