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Essential hypertension is a multifactorial disorder and is the main risk factor for renal and cardiovascular complications. The research on the genetics of hypertension has been frustrated by the small predictive value of the discovered genetic variants. The HYPERGENES Project investigated associations between genetic variants and essential hypertension pursuing a 2-stage study by recruiting cases

Between 1992 and 2008, 713 high hyperdiploid acute lymphoblastic leukemias in children aged 1-15 years were diagnosed and treated according to the Nordic Society for Pediatric Hematology and Oncology acute lymphoblastic leukemia 1992/2000 protocols. Twenty (2.8%) harbored t(1;19), t(9; 22), der(11q23), or t(12; 21). The median age of patients with "classic" high hyperdiploidy was lower than that o

The effects of the pyrethroid insecticide cypermethrin on a natural freshwater community were studied in small in situ enclosures over an 11-day period. The experiment was conducted in a eutrophic lake using a regression design that included three untreated controls and a gradient of six unreplicated cypermethrin concentrations, ranging from 0.01 to 6.1 mug/l. This paper is the first in a series o

We analyzed the presenting features and survival in 1689 patients with multiple myeloma aged younger than 50 years compared with 8860 patients 50 years of age and older. Of the total 10 549 patients, 7765 received conventional therapy and 2784 received high-dose therapy. Young patients were more frequently male, had more favorable features such as low International Staging System (ISS) and Durle-S

BACKGROUND AND PURPOSE: Malunion after a distal radius fracture can be treated with an osteotomy of the distal radius. Often autologous iliac crest bone graft is used to fill the gap, but this is associated with donor site morbidity. Instead of bone graft, we have used a slow-resorbing bone substitute in combination with a minimally invasive fixation technique. PATIENTS AND METHODS: 25 consecutive

Popular Abstract in Chinese 北极和亚北极地区对全球气候变化影响尤为重要。目前，北极地区正面临着变暖速度高于全球平均的现状。全球大约有50%的土壤碳储存在高纬度地区的土壤里，这些土壤碳主要分布于冻土层和泥炭层中。冻土层的解冻会使原先被冻结的土壤碳加速分解，产生温室气体，从而对全球变暖形成一个强烈的正反馈。与此同时，气温的增加可能会很大程度地影响植被在这些地区的生长和分布。动态生态系统模型是一种非常强大的工具，被用来研究气候变化对生态系统的影响，并且可以量化生态系统对大气的反馈信息。然而这些模型通常只关注大气、地表植被和土壤之间的水和碳的纵向转移，从而忽略了其在模型空间单元中的横向移动。这样可能会导致模型对于水和碳平衡的计算不够准确和全面，尤其在气候敏感的高纬度极地地区，这种偏差可能会更大。 本论文旨在解决动态生态系统模型中的这个局限性问题。基于目前最先进的动态生态The Arctic and Subarctic regions are of particular importance to the global climate change and are now experiencing a climate warming that is higher than the global average. Around 50% of the global soil carbon is stored in high latitude soils, especially in permafrost and peatland soils. Permafrost thawing, speeding up the decomposition of previously frozen soil carbon, is expected to result in s

This paper deals with new forms of political mobilisation and participation in social media. The main focus is on the importance of social networks in providing a “media filter”, functioning as a kind of collective gatekeeper to spread news and information perceived as important, in contrast to the image of the single individual media consumer faced with an insurmountable mass of information. I ar

En översiktlig genomgång av vilka texttyper som förekommo på de nordiska språken under 1500-, 1600- och 1700-talet: vilka som funnos kvar respektive försvunno av de medeltida och vilka som tillkommo såsom nya - uppdelat på olika samhällssfärer: kyrka, myndighetsutövning, undervisning och upplysning, privat offentlighet, privatliv.

The main objective was to study the effect on progression-free survival (PFS) of adding erlotinib to bevacizumab as maintenance treatment following chemotherapy and bevacizumab as first-line treatment of metastatic colorectal cancer (mCRC).

To analyse late morbidity and mortality in pre and post-menopausal breast cancer patients treated with postmastectomy radiotherapy, with emphasis on side-effects from the heart, cerebrovascular and respiratory systems.