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The interaction between mycobacteria and epithelium is unexplored, but may determine the outcome of the infection. We have analyzed the role of two G protein-coupled receptors, CXCR1 and CXCR2 that are important regulators of many pulmonary diseases. We found that mycobacteria significantly increased the expression of both CXCR1 and CXCR2 on alveolar epithelial cells and both receptors were found
To address the hotly debated question of motor system involvement in language comprehension, we recorded neuromagnetic responses elicited in the human brain by unattended action-related spoken verbs and nouns and scrutinized their timecourse and neuroanatomical substrates. We found that already very early on, from similar to 80 ms after disambiguation point when the words could be identified from
Antibody-based microarrays are among the new, rapidly emerging technologies within the field of proteomics that has the potential to evolve into a key proteomic research tool, providing novel means to perform early diagnostics, identify biomarkers and gain insights into disease biology. The aim of this thesis, based on five original papers, was to develop antibody microarrays based on human recom
Popular Abstract in Swedish Immunförsvaret, som även kan benämnas immunsystemet, kan betraktas som ett organ som är utspritt i hela kroppen istället för samlat på ett ställe. Immunsystemet består av ett stort antal vita blodkroppar som finns i blodet, ute i vävnaderna, samt samlade i lymfkörtlar och mjälten. Immunsystemets uppgift är att försvara oss från yttre faror som virus och bakterier samt aThe small intestine contains a large number of T lymphocytes within the single-layered epithelium that separates the gut lumen from the lamina propria. These intraepithelial T lymphocytes have potent cytolytic and immunoregulatory capacities, thought to be important for fighting infections, neoplastic growth, and sustaining epithelial integrity. This thesis is based on three original articles wit
Mean motion resonances are a common feature of both our own Solar system and of extrasolar planetary systems. Bodies can be trapped in resonance when their orbital semimajor axes change, for instance when they migrate through a protoplanetary disc. We use a Hamiltonian model to thoroughly investigate the capture behaviour for first- and second-order resonances. Using this method, all resonances of
Development of Object Clitics in Child L2 French A comparison of developmental sequences in different modes of acquisition
Professional women in the end of the 19ht and the beginning of the 20th century. Emancipation, women's rights, relationes between women and women, and women and men. Sexuality, hetero/homosexuality. Equality of the sexes.
By the autumn of 1966, the PRC government had enjoyed seventeen years of uninterrupted and complete domestic information dominance. Independent collection of information was hampered by way of a CCP culture of secrecy and successfully enforced regimen of information curtailment. Of the changes in the political landscape triggered by Mao Zedong’s August 1966 decision to label part of government off
We reportwhat is to our knowledge the first production of gain by inner-shell photoionization of ions. Photoionization of 4d electrons from In$+$ ions created a population inversion on a 185-nm In2$+$ transition. This scheme is an isoelectronic scaling of the 442-nm Cd$+$ laser. A single-pass gain constant of 0.9 {\textpm} 0.3 cm{\textminus}1 over a 0.4-cm path was pumped by soft x rays generated
The orbit of a planet is surrounded by a chaotic zone wherein nearby particles' orbits are chaotic and unstable. It was shown by Wisdom that the chaos is driven by the overlapping of mean motion resonances which occurs within a distance (δa/a)chaos≈ 1.3μ^2/7 of the planet's orbit. However, the width of mean motion resonances grows with the particles' eccentricity, which will increase the width of
Validated planet candidates need not lie on long-term stable orbits, and instability triggered by post-main-sequence stellar evolution can generate architectures which transport rocky material to white dwarfs, hence polluting them. The giant planet HD 131399Ab orbits its parent A star at a projected separation of about 50-100 au. The host star, HD 131399A, is part of a hierarchical triple with HD
This study examines the determinants of exit from academic research that occurs when academic researchers move into positions in academe that concentrate on nonresearch activities such as teaching or administration or when researchers leave academia and move into industry. Drawing on career data for 14,000 Japanese PhD graduates in hard sciences (all scientific fields except social sciences and hu
The complement system is an arm of innate immunity that aids in the removal of pathogens and dying cells. Due to its harmful, pro-inflammatory potential, complement is controlled by several soluble and membrane-bound inhibitors. This family of complement regulators has been recently extended by the discovery of several new members, and it is becoming apparent that these proteins harbour additional
Background Semaglutide is a novel glucagon-like peptide-1 (GLP-1) analogue, suitable for once-weekly subcutaneous administration, in development for treatment of type 2 diabetes. We assessed the efficacy and safety of semaglutide versus the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin in patients with type 2 diabetes inadequately controlled on metformin, thiazolidinediones, or both. Method
