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The use of passive house technique has been used in a new wood framed building in Sweden. Besides the positive effect of reduced energy need, highly insulated wooden houses often have a higher risk of moisture and mould problems. The reason is that critical positions is more exposed to higher relative humidity compared to ordinary houses with thinner insulation. To investigate if an external wall
Many studies focusing on the design activity use the interview technique as a part of their investigation. Methodological discussions about the interview setting as the locus of a social interaction between the interviewer and the respondent and its implications for the interpretation of the obtained data are nevertheless rarely found in publications within our design community. Part I of this pub
Canonical bases, also called SAGBI bases, for subalgebras of the non-commutative polynomial ring are investigated. The process of subalgebra reduction is defined. Methods, including generalizations of the standard Gröbner bases techniques, are developed for the test whether bases are canonical, and for the completion procedure of constructing canonical bases. The special case of homogeneous subalg
During B lymphocyte development, the transcriptional activity of the IgH locus is subject to spatial and temporal changes. The 3' enhancer (3'E) has been suggested to play an important role in regulation of immunoglobulin gene expression late in B cell development. We have investigated, using transgenic mice, the role of the 3'E in regulating Ig gene expression. Mice harbouring a rearranged IgH ge
Popular Abstract in Swedish Användningen av konstgjorda material för temporärt och permanent bruk, t.ex katetrar, skruvar, ledproteser är numera väl etablerad inom human- medicinen. Dessa sk biomaterial kan emellertid predisponera till proppbildning, inflammatoriska vävnadsreaktioner och infektioner i omgivande vävnad, ledande till svåra komplikationer, såsom blod- förgiftning, passagestopp samt pResident skin micro-organisms such as S. epidermidis and other coagulase-negative staphylococci (CoNS), are by far the most common causes of biomaterial-associated infections. These micro-organisms often exhibit surface adhesins that specifically bind serum and tissue proteins adsorbed to implanted biomaterials. The aim of this study was to extend our knowledge about such adhesins produced by CoNS
Eukaryotic cells possess sensitive systems for the detection of microbes and microbial-derived products. Bacteria-eukaryotic cells contact triggers several signaling pathways, most of which are dependent on protein-protein interactions followed by phosphorylation, leading to activation of defense mechanisms. Yersinia bacteria have evolved different strategies to interfere with eukaryotic host defe
Popular Abstract in Swedish Immunsystemet består av en specifik och en ospecifik del som samarbetar när ett immunsvar sätts igång. Den specifika delen utgörs av T och B celler som med specifika ytreceptorer, så kallade antigen-receptorer, känner igen och aktiveras av främmande ämnen (antigen). För att T celler skall aktiveras av antigen, krävs det att dendritiska celler inom den ospecifika delen aImmunological self-tolerance is a state of the whole organism where deleterious responses are either avoided or regulated. Breaking of immunological tolerance will lead to autoimmune disease or chronic inflammatory conditions. T cell maturation in the thymus generates a peripheral T cell pool with an enormous TCR repertoire, from which specific T cells are selected and activated upon encounters wi
Popular Abstract in Swedish När vi blir infekterade av virus eller bakterier (patogener) hjälper olika delar av vårt immunförsvar till att försvara oss från dem. Vår hud, slemhinnor, magsyra och vissa immunceller hjälper till att ospecifikt och snabbt hindra patogenerna från att angripa oss och ofta räcker detta för att infektionen skall klaras av. Men det finns en del till av vårt immunförsvar soT lymohocytes (T cells) and B lymphocytes (B cells) are important effector cells of the adaptive immune system. In response to infections, B cells are activated and produce antibodies against specific antigens. There are two types of T cells, cytotoxic T cells that kill cells infected with bacteria or viruses, and helper T (Th) cells that help B cells produce antibodies by secreting cytokines as w
The sound transmission in double walls at low frequencies is studied using a detailed geometric model, based on FEM. The model simulates the experiments carried out to determine the sound reduction index of the wall. The wall properties effect on the sound transmission loss is investigated and also how the sound reduction is affected by the dimensions of the connecting rooms.
The human papillomavirus type 16 (HPV16) life cycle can be divided into an early stage in which the HPV16 genomic DNA is replicated, and a late stage in which the HPV16 structural proteins are synthesized and virions are produced. A strong coupling between the viral life cycle and the differentiation state of the infected cell is highly characteristic of all HPVs. The switch from the HPV16 early g
PurposeThe purpose is to provide a structured method for prioritising among the diversity of motives and goals of stakeholders involved in city logistics.Design/methodology/approachThe paper is based on a three-year participant observation study in a city logistics project including ten stakeholders. The data relate to the understanding gained during the three years of study and nine semi-structur
Skin photoprotection is commonly believed to rely on the photochemistry of 5,6-dihydroxyindole (DHI)- and 5,6-dihydroxyindole-2-carboxylic acid (DHICA)-based eumelanin building blocks. Attempts to elucidate the underlying excited-state relaxation mechanisms have been partly unsuccessful due to the marked instability to oxidation. We report a study of the excited-state deactivation of DHI using ste
BACKGROUND: The study was carried out to evaluate the expression of major histocompatibility complex (MHC) molecules in retinal transplants with different tissue integrity.METHODS: Twelve adult rabbits received an allogeneic subretinal neuroretinal transplant, in the form of either fragmented embryonic cells or a complete full-thickness embryonic retina. A controlled transvitreal approach was used
Type of Study: This is a longitudinal, case-control clinical trial. Objectives: This study aims to track recovery time following a vocal loading task (VLT) imposing vocal fatigue and to explore if patients with functional dysphonia (FD) are worse affected by vocal loading, and if these patients take longer than others to recover. Methods: Fifty (n = 50) female participants in four vocal subgroups
Establishing diagnostic reference levels (DRLs) in a big country is complicated due to differences in radiological practice between different regions. In 2009-2014, a dose survey was performed in six Russian regions. Based on the results of the survey, preliminary DRLs for conventional X-ray examinations were established on a national level. Additionally, the local authorities were granted the pos
Mitochondrial diabetes mellitus (MDM) presenting with a mitochondrial DNA 3243 (A-G) mutation is most frequently observed in patients with diabetes caused by a genetic defect. Clinical manifestations include short stature, the absence of obesity, young-onset, and the maternal inheritance of diabetes. MDM is strongly associated with neurosensory deafness, which is often overlooked during routine me
Thromboxane A2 (TXA2) acts on TXA2 receptors (TP) to regulate renal artery blood flow and subsequently contributes to the pathogenesis of renal ischemia. The present study was designed to examine if nuclear factor-kappaB (NF-B) signaling pathway is involved in the downregulation of TP receptors in rat renal artery. Rat renal artery segments were organ cultured for 6 or 24 h. Downregulation of TP r
