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We present a compact HHG source driven by a few-cycle, few μJ, 200 kHz OPCPA system. Efficient harmonics are generated from Neon, Argon and Krypton with conversion efficiency of 4.0×10-8, 1.2×10-6 and 4.1×10-6, respectively.

Context: Lynch syndrome (LS) is a cancer-predisposing syndrome caused by germline mutations in genes involved in DNA mismatch repair (MMR). Patients are at high risk for several types of cancer, but pituitary tumors have not previously been reported.Case: A 51-year-old man with LS (MSH2 mutation) and a history of colon carcinoma presented with severe Cushing disease and a locally aggressive pituit

Background: In order to increase coverage in the organized cervical screening program, self-sampling with HPV analyses has been suggested. Objectives: The aim was to compare human papillomavirus (HPV) mRNA detection in vaginal and urine self-collected samples with clinician-taken cervical samples and the corresponding clinician-taken histological specimens. Study design: Self-collected vaginal, ur

In this contribution, we report about tomographic nanoscale imaging using a laser-produced plasma-based laboratory transmission X-ray microscope (LTXM) in the water window. The soft X-ray radiation of the LTXM is provided by a high average power laser-produced (1.3 kHz repetition rate, 0.5 ns pulse duration, 140 W average power) plasma source, a multilayer condenser mirror, an objective zone plate

From an evolutionary point of view a pathogen might benefit from regulating the inflammatory response, both in order to facilitate establishment of colonization and to avoid life-threatening host manifestations, such as septic shock. In agreement with this notion Streptococcus pyogenes exploits type I IFN-signaling to limit detrimental inflammation in infected mice, but the host-pathogen interacti

The fifth generation wireless system (5G) is expected to handle an unpredictable number of heterogeneous connected devices and to guarantee at least the same level of security provided by the contemporary wireless standards, including the Authentication and Key Agreement (AKA) protocol. The current AKA protocol has not been designed to efficiently support a very large number of devices. Hence, a n

Data rate requirements for cellular communications are expected to increase 1000–fold by 2020, compared to 2010. This is mainly because of the rapid increase in the number of wireless devices and data hungry applications per–device. This creates a formidable bandwidth crisis. Milimeter–wave (mmWave) systems with massive multiple–input multiple–output (MIMO) operation are two complementary concepts

During the last years, numerous research projects focussed on re-examination of past excavations, giving birth to re-evaluation of their documentation and material or to new discoveries. The aim of this paper is to present an ongoing research on the digital re-assessment of the Ayia Irini sanctuary’s stratigraphy using 3D GIS, by corroborating published material with data extracted from the origin

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate

Civil society is often understood as a normative vehicle for the promotion of human rights and democracy, as it plays a central role in ensuring gender equality and advocating for local ownership in the decision-making processes of states. Civil society agents and organizations have been instrumental in promoting and advancing the Women, Peace, and Security (WPS) agenda. In this chapter, we examin

Insect genitalia are important for species identification and taxonomy and are key traits for the evolution of reproductive isolation through their 'lock-And-key mechanism'. Nevertheless, few studies have evaluated intraspecific variation and the impact of seasonal environmental variation on genital morphology. We used geometric morphometric analysis to quantify male genital morphology within and

We use a carbon-cycle data assimilation system to estimate the terrestrial biospheric CO2 flux until 2090. The terrestrial sink increases rapidly and the increase is stronger in the presence of climate change. Using a linearized model, we calculate the uncertainty in the flux owing to uncertainty in model parameters. The uncertainty is large and is dominated by the impact of soil moisture on heter

This paper presents stability theory of adaptive systems using an extension of the Yakubovich-Kalman-Popov (YKP) lemma. Such stability analysis is relevant for observer-based adaptive feedback control systems. Relaxation of the controllability and observability conditions imposed in the YKP lemma can be made for a class of adaptive systems described by a linear time-invariant (LTI) system with ada

Activity-based financing (ABF) and global budgeting are two common reimbursement models in hospital care that embody different incentives for cost containment and quality. The purpose of this study was to explore and describe perceptions from the provider perspective about how and why replacing variable ABF by global budgets affects daily operations and provided services. The study setting is a la

Background: Although studies have shown associations between neighbourhood quality and chronic disease outcomes, such associations are potentially confounded by the selection of different types of people into different neighbourhood environments. We sought to identify the causal effects of neighbourhood deprivation on type 2 diabetes risk, by comparing refugees in Sweden who were actively disperse

Many existing protocols for neuronal differentiation of human pluripotent cells result in heterogeneous cell populations and unsynchronized differentiation, necessitating the development of methods for labeling specific cell populations. Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression pattern

Aminoguanidine (AMG) was prepared more than 100 years ago. During the last 10 years two important effects of AMG have been discovered which have made this molecule attract a lot of interest. Firstly, AMG inhibits, in vitro and in vivo, formation of highly reactive advanced glycosylation end products (AGEs) associated with pathogenesis of secondary complications to diabetes and with cardiovascular