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The conditions for binding of antibodies to glycosphingolipids separated on a thin-layer plate have been optimized for polyclonal antisera. The method has a broad detection range with low background staining. Examples are shown for the detection of blood group A and B active glycosphingolipids.
Myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease in rats that closely mimics many clinical and histopathological aspects of multiple sclerosis. Non-MHC quantitative trait loci regulating myelin oligodendrocyte glycoprotein-induced EAE have previously been identified in the EAE-permissive strain, DA, on rat chromosomes 4,10,15, a
We conduct a series of comparisons between spectroscopic and photometric observations of globular clusters and stellar models to examine their predictive power. Data from medium-to-high resolution spectroscopic surveys of lithium allow us to investigate first dredge-up and extra mixing in two clusters well separated in metallicity. Abundances at first dredge-up are satisfactorily reproduced but th
Over the past few decades, numerous wide (> 103 au) binaries in the Galactic field and halo have been discovered. Their existence cannot be explained by the process of star formation or by dynamical interactions in the field, and their origin has long been a mystery. We explain the origin of these wide binaries by formation during the dissolution phase of young star clusters: an initially unbound
Genetic and environmental factors, including the commensal microbiota, have a crucial role in the development of inflammatory bowel disease. Aberrant activation of the transcription factor NF-κB is associated with chronic intestinal inflammation in mice and humans. Recently, an emerging family of innate lymphoid cells (ILCs) has been identified at mucosal sites contributing to the maintenance of g
The aggregation of the 42-residue form of the amyloid-β peptide (Aβ42) is a pivotal event in Alzheimer's disease (AD). The use of chemical kinetics has recently enabled highly accurate quantifications of the effects of small molecules on specific microscopic steps in Aβ42 aggregation. Here, we exploit this approach to develop a rational drug discovery strategy against Aβ42 aggregation that uses as
Asymptomatic bacteriuria (ABU) is a bacterial carrier state in the urinary tract that resembles commensalism at other mucosal sites. ABU strains often lack the virulence factors that characterize uropathogenic Escherichia coli (E. coli) strains and therefore elicit weak innate immune responses in the urinary tract. In addition, ABU strains are active modifiers of the host environment, which they i
The past few decades have seen an increasing demand for environmental information on which to make more informed decisions, strengthened by several international calls for improving available environmental information. In a democratic South Africa, the involvement of people in policy and decision-making processes has led to an even greater need for accessible information. In response to this deman
Building on narratives of students in adult education in Sweden, where the majority of the students are young adults, this paper argues that adult education has both negative and positive aspects in helping individuals to be recognised as valuable. Students, often part of the precariat class, have not always been able to survive in the job market and have a history of failing in upper secondary sc
Manual selection of finger trabecular bone texture regions on hand X-ray images is time-consuming, tedious, and observer-dependent. Therefore, we developed an automated method for the region selection. The method selects square trabecular bone regions of interest above and below the second to fifth distal and proximal interphalangeal joints. Two regions are selected per joint (16 regions per hand)
Upphovsrätten präglas av flera svåra gränsdragningar varav denna uppsats fördjupar sig inom en av dessa. Svårigheten som behandlas i detta sammanhang består av problematiken att avgöra var gränsen går mellan ett skyddat verk och en oskyddad idé. Vissa aspekter inom området är tydliga, i form av att enbart en idé inte kan åtnjuta upphovsrättsligt skydd medan en färdig produkt har möjlighet till skyThe Copyright law is filled with difficulties regarding boundaries of with this thesis deepens itself within one of these. The difficulty in this context consists of the problem of determining where the boundaries, in which a work can be qualified for copyright protection, lies between a protected work and an unprotected idea. Since certain aspects of the field are clear, in the form of that an id
The study done in this thesis was based on a planned eco village in Röstånga, Sweden. The aim of the study was to find a solution into which energy- and ventilation systems that were sustainable and had the least environmental impact in combinations with each other and the chosen building materials. This has been done through literature studies, simulations and life cycle analysis based on those t
Vegetationsbränder är världsomspännande problem som skakar samhällen genom att skada deras ekonomier och orsaka allvarliga, ibland dödliga, hälsokomplikationer bland deras befolkningar. Takten av vegetationsbrandsförekomst har ökat de senaste åren till följd av en stigande global medeltemperatur. Denna takt förväntas att fortsätta öka på grund av den globala uppvärmningen. I efterdyningarna av braWildfires are worldwide problems that stress societies by damaging their economies and they cause serious, sometimes fatal, health implications among the populations. In recent years, the rate of wildfire occurrence has increased as the global average temperature has risen. Because of global climate change, this rate is expected to continue rising. In Sweden, in the aftermath of the 2014 Västmanla
The research objective for this thesis are two problematic yet interweaving occurrences observed in earlier research on the Abu Ghraib scandal (2004) and its image material. Firstly in terms of methodology, a restricted amount of images in which three single images, “Hooded Man”, “Man on Leash” and “Piled Bodies” are overrepresented and frequently regarded as descriptive for the scandal as such. S
We consider Bayesian inference for stochastic differential equation mixed effectsmodels (SDEMEMs) exemplifying tumour response to treatment and regrowth in mice. We produce an extensive study on how an SDEMEM can be fitted by using both exact inference based on pseudo-marginal Markov chain Monte Carlo sampling and approximate inference via Bayesian synthetic likelihood (BSL). We inv
Ternary alloyed CdSexTe1–x colloidal QDs trap-passivated by iodide-based ligands (TBAI) are developed as building blocks for UV–NIR photodetectors. Both the few surface traps and high loading of QDs are obtained by in situ ligand exchange with TBAI. The device is sensitive to a broad wavelength range covering the UV–NIR region (300–850 nm), showing an excellent photoresponsivity of 53 mA/W, a fast
Bacterial proteases are important enzymes used in several technical applications where controlled cleavage of proteins is needed. They are challenging enzymes to express recombinantly as parts of the proteome can be hydrolyzed by their activity. The eukaryotic model organism Saccharomyces cerevisiae is potentially a good expression host as it tolerates several stress conditions and is known to bet
Lactic acid bacteria with antifungal properties are applied for biopreservation of food. In order to further our understanding of their antifungal mechanism, there is an ongoing search for bioactive molecules. With a focus on the metabolites formed, bioassay-guided fractionation and comprehensive screening have identified compounds as antifungal. Although these are active, the compounds have been
