Filetype
Text visualization techniques often make use of automatic text classification methods. One of such methods is stance analysis, which is concerned with detecting various aspects of the writer's attitude towards utterances expressed in the text. Existing text visualization approaches for stance classification results are usually adapted to textual data consisting of individual utterances or short me
While immunomodulatory monoclonal antibodies (mAbs) have therapeutic efficacy against many tumors, few patients are cured. Attempting to improve their therapeutic efficacy we have applied the TC1 mouse lung carcinoma model and injected established subcutaneous tumors intratumorally with 3 weekly doses of various combinations of mAbs. Combinations of mAbs to CTLA4/PD1/CD137 (the 3 mAb combination)
In vitro generation of antibodies often requires variable domain sequence evolution to adapt the protein in terms of affinity, specificity, or developability. Such antibodies, including those that are of interest for clinical development, may have their origins in a diversity of immunoglobulin germline genes. Others and we have previously shown that antibodies of different origins tend to evolve a
Understanding hydrological processes in the Source Area of the Yellow River (SAYR), Qinghai-Tibet Plateau, is vital for protection and management of groundwater and surface water resources in the region. In situ water measurements of exchange rates between surface water and groundwater are, however, hard to conduct because of the harsh natural conditions of the SAYR. We here present an indirect me
The nervous system is engaged by infection, indirectly through inflammatory cascades or directly, by bacterial attack on nerve cells. Here we identify a neuro-epithelial activation loop that participates in the control of mucosal inflammation and pain in acute cystitis. We show that infection activates Neurokinin-1 receptor (NK1R) and Substance P (SP) expression in nerve cells and bladder epitheli
The development of functionally competent, self-tolerant T cells in the thymus is an essential prerequisite for the formation of adaptive immune responses against foreign pathogens. Thymic epithelial cells (TECs) form specialized stromal microenvironments in the cortex (cTEC) and medulla (mTEC) of the thymus that support all stages of T cell development, from the entry of thymocyte progenitors to
The goal of this study has been to establish a method for quantifying the minimum chip thickness, h1min, during longitudinal turning of duplex stainless steel, and explore how the value of h1min changes with varying process parameters. Based on experimental results, it was found that the tool edge radius only has a limited influence on the size of h1min up to a certain feed level after which the c
The requirements on high efficiency and low emissions of internal combustion engines (ICEs) raise the research focus on advanced combustion concepts, e.g., premixed-charge compression ignition (PCCI), partially premixed compression ignition (PPCI), reactivity controlled compression ignition (RCCI), partially premixed combustion (PPC), gasoline compression ignition (GCI) etc. In the present study,
Follicular helper T cells (Tfh) are specialized helper T cells that are predominantly located in germinal centers and provide help to B cells. The development and differentiation of Tfh cells has been shown to be regulated by transcription factors, such as B-cell lymphoma 6 protein (Bcl-6), signal transducer and activator of transcription 3 (STAT3) and B lymphocyte-induced maturation protein-1 (Bl
Background Worse outcomes have been noted in patients with multiple primary melanomas (MPMs) than in patients with single primary melanomas. Objective We investigated how family history of melanoma and germline CDKN2A mutation status of MPM patients affects risks of developing subsequent melanomas and other cancers and survival outcomes. Methods Comprehensive data on cancer diagnoses and deaths of
Galectin-3 is an endogenous β-galactoside-binding lectin comprising a carbohydrate recognition domain (CRD) linked to a collagen-like N-domain. Both domains are required for galectin-3 to induce cellular effects; a C-terminal fragment of galectin-3, galectin-3C, containing the CRD but lacking the N-domain, binds cell surface glycoconjugates but does not induce cellular effects since cross-linking
Parasites are expected to exert long-term costs on host fecundity and longevity. Understanding the consequences of heritable polymorphic variation in disease defence in wild populations is essential in order to predict evolutionary responses to changes in disease risk. Telomeres have been found to shorten faster in malaria-diseased individuals compared with healthy ones with negative effects on lo
Objectives To describe the incidence of atrioventricular (AV) block II-III, atrial fibrillation (AF), pacemaker implantation (PM) and aortic regurgitation in patients with ankylosing spondylitis (AS), undifferentiated spondyloarthritis (uSpA) and psoriatic arthritis (PsA) compared with the general population (GP) and with each other. Methods A prospective nationwide study with cohorts of patients
The Roman historian Tacitus is not only our most important source for the Early Roman Empire, but also a literary artist second to none. His fragmentarily preserved Annales deals with the imperial rule established by the first emperor Augustus, the Julio-Claudian dynasty (AD 14 – 68). Through his scathing analyses of the consequences of autocratic government, Tacitus has established himself as an
Tissue damage is usually regarded as a necessary price to pay for successful elimination of pathogens by the innate immune defense. Yet, it is possible to distinguish protective from destructive effects of innate immune activation and selectively attenuate molecular nodes that create pathology. Here, we identify acute cystitis as an Interleukin-1 beta (IL-1β)-driven, hyper-inflammatory condition o
Children can and should be encouraged to take an active part in their own care. With the introduction of online health care centers, where the main interaction is provided through digital consultations, the process for including the child must be revised. In addition to the medical and legal challenges, the digital interface needs to be designed so that the parent is encouraged to involve the chil
Buildings are getting taller due to increased urbanisation and densification of cities. More advanced construction methods and the desire to construct impressive buildings is also supporting the trend. Due to their inherent slenderness resulting in low eigenfrequencies, these buildings are susceptible to wind-induced vibrations which can be highly disturbing for occupants. Already barely perceivab
This paper presents a fully automated method for segmentation of 3D SPECT ventilation and perfusion images. It relies on statistical information on lung shape derived by CT manual segmentation and its main processing steps are: shape model extraction, binary segmentation, positioning of mean shape in SPECT images and iterative shape adaptation based on intensity profiles and on what is considered
