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It is tempting to assume that Information Systems Development Methodology (ISDM) is clearly understood because it has attracted researchers across a range of research fields offering a rich set of descriptions and explanations of ISDM. Although there are considerable studies on ISDM, this paper argues that different disciplinary interests have resulted in fragmented assessments. Consequently, this
In this paper, we describe a system that automatically converts narratives into 3D scenes. The texts, written in Swedish, describe road accidents. One of the program’s key features is that it animates the generated scene using temporal relations between the events. We believe that this system is the first text-to-scene converter that is not restricted to invented narratives. The system consists of
Clock nets are the major source of power consumption in large, high-performance ASICs and a design bottleneck when it comes to tolerable clock skew. A way to obviate the global clock net is to partition the design into large synchronous blocks each having its own clock. Data with other blocks is exchanged asynchronously using handshake signals. Adopting such a strategy requires a methodology that
We consider the problem of stochastic control under power constraints. Problems such as linear quadratic optimal control with information constraints are instances of the problem considered. The calculations of the optimal control law can be done off-line as in the classical linear quadratic Gaussian control theory using dynamic programming, which turns out to be a special case of the new theory d
We have investigated the interactions between cationic poly(amidoamine) (PAMAM) dendrimers of generation 4 (G4), a potential gene transfection vector, with net-anionic model biomembranes composed of different ratios of zwitterionic phosphocholine (PC) and anionic phospho-l-serine (PS) phospholipids. Two types of model membranes were used: solid-supported bilayers, prepared with lipids carrying pal
To determine factors associated with the antipsychotic (AP) prescription for people with dementia (PwD) recently admitted to institutional long-term care facilities (LTCFs) and to ascertain differences in the use of this medication in 8 European countries.
A physically-based, distributed hydrological model (MIKE SHE) was used to quantify overland runoff in response to four extreme rain events and four types of simulated land use measure in a catchment in Norway. The current land use in the catchment comprises arable lands, forest, urban areas and a stream that passes under a motorway at the catchment outlet. This model simulation study demonstrates
To assess the diagnostic performance of urine lipoarabinomannan (LAM) detection for TB screening in HIV-positive adults in Ethiopia.
The article examines specimens from five Latin sermon collections that were widely used as models for sermon composition in the later Middle Ages. Four of the collections were studied in incunable editions. One of the results is that the only day of the eclesiastical year on which one finds a more or less regular discussion of the Last Judgement is the first or second Sunday of Advent. The subject
Popular Abstract in Swedish Populärvetenskaplig sammanfattning Öroninflammtionen är en av våra vanligaste åkommor, och den drabbar framför allt små barn. Av alla bakteriella infektioner är det den som oftast för oss till läkare. Vanligen resulterar läkarbesöket i en kur med bakteriedödande läkemedel som penicillin. P.g.a den idag höga konsumtionen av penicillin och liknande medel, är risken påtagAcute otitis media (AOM) is the most common illness diagnosed during early childhood. One of the major etiologic agents is Haemophilus influenzae. Apart from AOM, this organism can cause a broad range of infectious diseases such as meningitis, epiglottitis, arthritis, and pneumonia. Despite the importance of H.influenzae, the mechanisms by which this heterogenous group of bacteria mediates the inf
Sequential isolates from eight cynomolgus monkeys experimentally infected with Simian immunodeficiency virus (SIVsm, of sooty mangabey origin) were tested for coreceptor use in the human osteosarcoma indicator cell line, GHOST(3), expressing CD4 and one or another of the chemokine receptors CCR3, CCR5, CXCR4, BOB, or the orphan receptor Bonzo. The indicator cell line carries the human immunodefici
Egypt has one of the world's highest prevalences of hepatitis C virus (HCV) infection, with a majority of genotype 4 infections. To explore the genetic diversity of HCV in Egypt, sera from 131 Egyptians [56 from community studies, 37 chronic hepatitis patients, 28 hepatocellular carcinoma (HCC) patients and 10 patients with non-Hodgkin's lymphoma] were genotyped by restriction fragment-length poly
The pattern of autoimmune diseases in childhood cancer survivors has not been investigated previously. We estimated the risk for an autoimmune disease after childhood cancer in a large, population-based setting with outcome measures from comprehensive, nationwide health registries.
Den här guiden ger lokala politiker och tjänstemän ett processorienterat verktyg för att stärka förankringen (integrationen) av klimatanpassning i relevanta sektorer av kommunal verksamhet, med syftet att främja en hållbar stadsutveckling. Den kan därför ses som ett instrument för att vägleda en integrationsprocess. Guiden presenterar systematiskt de nivåer och områden där förankring av klimatanpaThis guideline offers local government officers and local politicians process-oriented assistance for integrating climate change adaptation within relevant sectors of municipal administration with the aim of fostering sustainable urban development. It is thus an instrument to support leadership of this integration process. The levels and areas where integration of climate change adaptation is rele
Autoantibodies to insulin (IAA) are one of the first markers of the autoimmune process leading to type 1 diabetes (T1D). While other autoantibodies in T1D have been studied extensively, relatively little is known about IAA and their binding specificities, especially after insulin treatment is initiated. We hypothesize that insulin antibodies (IA) that develop upon initiation of insulin treatment d
Sequential serum samples from four plasma donors (designated A, B, C, and D) at a Chinese blood bank with hepatitis C transmission problems were studied from 1994 to 1997. The samples were examined for antibodies to HCV, for HCV viremia by PCR and HCV genotyping. Co- and superinfections were studied by direct sequencing of the 5'-NCR, core, and HVR-1 regions, using low and high genotype-specific p
Background: More than ever, clinicians need regularly updated reviews given the continuously increasing amount of new information regarding innovative cervical cancer prevention methods. Material and methods: A summary is given from recently published meta-analyses on three possible clinical applications of human papillomavirus (HPV)-DNA testing: triage of women with equivocal or low-grade cytolog
A functionally distinct subset of CD103(+) dendritic cells (DCs) has recently been identified in murine mesenteric lymph nodes (MLN) that induces enhanced FoxP3(+) T cell differentiation, retinoic acid receptor signaling, and gut-homing receptor (CCR9 and alpha 4 beta 7) expression in responding T cells. We show that this function is specific to small intestinal lamina propria (SI-LP) and MLN CD10
Recombinant adeno-associated viral vectors display efficient tropism for transduction of the dopamine neurons of the substantia nigra. Taking advantage of this unique property of recombinant adeno-associated viral vectors, we expressed wildtype and A53T mutated human alpha-synuclein in the nigrostriatal dopamine neurons of adult rats for up to 6 months. Cellular and axonal pathology, including alp
