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Histopathological diagnosis of pulmonary tumors is essential for treatment decisions. The distinction between primary lung adenocarcinoma and pulmonary metastasis from the gastrointestinal (GI) tract may be difficult. Therefore, we compared the diagnostic value of several immunohistochemical markers in pulmonary tumors. Tissue microarrays from 629 resected primary lung cancers and 422 resected pul
Aim: The main objective of the current study was to explore the value of risk-adjustment when comparing (i.e. benchmarking) long-term overall survival (OS) in breast cancer (BC) between Swedish regions. We performed risk-adjusted benchmarking of 5- and 10-year OS after HER2-positive early BC diagnosis between Sweden's two largest healthcare regions, constituting approximately a third of the total
PURPOSE: Opioid use disorder has caused significant morbidity and mortality resulting in opioid prescribing limiting laws, such as State Bill 273 in West Virginia. The purpose of this study is to explore the impacts of a restrictive opioid prescription law on physicians in medical practice in West Virginia. METHODS: A qualitative study with open-ended semistructured interviews with a purposive sam
Objective: Meniscal calcifications are associated with the pathogenesis of knee osteoarthritis (OA). We propose a micro-computed tomography (μCT) based 3D analysis of meniscal calcifications ex vivo, including a new grading system. Method: Human medial and lateral menisci were obtained from 10 patients having total knee replacement for medial compartment OA and 10 deceased donors without knee OA (
Human papillomavirus (HPV) is the main causal agent of tonsillar cancer (TC) and HPV+ TC has a favorable prognosis compared to HPV– disease. In this study, we examined aspects of the tumor microenvironment of TC, focusing on T‐cells, dendritic cells (DC), and macrophages. Fresh biopsies of TC and the contralateral healthy tonsil (HT) were obtained from 20 patients, analyzed by multiparameter flow
AIM: To investigate the changes in prevalence and incidence of pharmacologically and non-pharmacologically treated diabetes in Sweden during 2005 to 2013.METHODS: We obtained data on gender, date of birth and pharmacologically and non-pharmacologically treated diabetes from national registers for all Swedish residents.RESULTS: During the study period a total of 240 871 new cases of pharmacological
Polymorphisms in genes in the human leukocyte antigen (HLA) class II region comprise the most important inherited risk factors for many autoimmune diseases including type 1 diabetes (T1D) and celiac disease (CD): both diseases are positively associated with the HLA- DR3 haplotype (DRB1*03:01-DQA1*05:01-DQB1*02:01). Studies of two different populations have recently documented that T1D susceptibili
Background: Gene expression (GEX) signatures in breast cancer provide prognostic information, but little is known about their predictive value for tamoxifen treatment. We examined the tamoxifen-predictive value and prognostic effects of different GEX signatures in premenopausal women with early breast cancer. Methods: RNA from formalin-fixed paraffin-embedded tumor tissue from premenopausal women
BACKGROUND: Exposure to ionizing radiation increases the risk of chronic metabolic disorders such as insulin resistance and type 2 diabetes. Internal ionizing radiation from inhaled radioactive aerosol may contribute to the associations between fine particulate matter (PM2.5) and gestational diabetes mellitus (GDM).METHODS: We used the Massachusetts Registry of Vital Records to study 1,061,937 pre
BACKGROUND Targeted temperature management is recommended for patients after cardiac arrest, but the supporting evidence is of low certainty. METHODS In an open-label trial with blinded assessment of outcomes, we randomly assigned 1900 adults with coma who had had an out-of-hospital cardiac arrest of presumed cardiac or unknown cause to undergo targeted hypothermia at 33°C, followed by controlled
4D printing is a development in additive manufacturing that enables 3D printed objects to transform over time in response to environmental stimuli. This research investigates the architectural viability of large-scale fused deposition modeling (FDM) 3D printing of thermoplastics onto stretched textiles, which retract and warp into 3D structures upon release. Employing an iterative research-by-desi
Muscle-invasive bladder cancer (MIBC) is characterised by significant molecular heterogeneity, with the tumour composition being further sculptured by local microenvironmental influences. This inherent complexity contributes to the divergent disease trajectories and the variable therapeutic susceptibility observed among patients. Consequently, there is an evident need for prognostic and predictive
The educational opportunities of refugee learners are shaped by forces of globalization, restrictive mobility regimes and geopolitical agendas, that place them in a position of structural disadvantage. The majority of the world's refugee learners have fled due to armed conflict and reside in neighboring countries in the global South. In many cases forced displacement is protracted, with limited gl
Background: Psychological resilience refers to a person's positive adaptation when faced with adversities, such as a breast cancer (BC) diagnosis. Highly resilient patients are more likely to regain stability and be protected from health conditions such as depression, anxiety, and posttraumatic stress disorder. We aimed to identify epigenetic markers that distinguish high- and low-resilient patien
BackgroundMolecular subtypes of lung adenocarcinoma (LUAD) with varying prognosis and characteristics have been proposed based on one or two-dimensional studies but are not yet implemented into clinical routine. Epigenetic modifications in cancer cells are independent of sequence variants, directly linked to gene and genome regulation, and thus provide important information to guide subclassificat
1 Regional Training Course on Rights-Based and Inclusive Approaches to Early Warning, Evacuation and Camp Management Revised Q2 2022 Supported by 2 This manual has been developed by Dr Matthew Scott (Raoul Wallenberg Institute) in collaboration with national representatives to the Asia Preparedness Partnership (APP) from Cambodia, Myanmar, the Philippines, Pakistan, Nepal and Sri Lanka and themati
Plan för globalt dynamiskt engagemang – färdplaner 2026 FÖRSÄTTSSIDA STYRDOKUMENT Plan för globalt dynamiskt engagemang – färdplaner 2026 Typ av styrdokument: Plan Definition av typen av styrdokument: Planer innehåller konkreta åtgärder som behövs för att mål i exempelvis strategier och policyer ska uppnås, kan innehålla en sammanställning av aktiviteter som tillsammans ska leda till att uppnå mål
https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2026-01/plan-for-gde-fardplaner-2026.pdf - 2026-07-06
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Allogeneic hematopoietic cell transplantation (allo-HCT) is an effective immunotherapeutic approach for various hematologic and immunologic ailments. Despite the beneficial impact of allo-HCT, its adverse effects cause severe health concerns. After transplantation, recognition of host cells as foreign entities by donor T cells induces graft-vs.-host disease (GVHD). Activation, proliferation and tr
