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Second mitochondria-derived activator of caspase (SMAC) mimetics (SMs) are selective antagonists of the inhibitor of apoptosis proteins (IAPs), which activate noncanonical NF-B signaling and promote tumor cell death. Through gene expression analysis, we found that treatment of CD4+ T cells with SMs during T helper 17 (TH17) cell differentiation disrupted the balance between two antagonistic transc
Endo-β-N-acetylglucosaminidase (EndoS) is a family 18 glycosyl hydrolase secreted by Streptococcus pyogenes. Recombinant EndoS hydrolyzes the β-1,4-di-N-acetylchitobiose core of the N-linked complex type glycan on the asparagine 297 of the γ-chains of IgG. Here, we report that EndoS and IgG hydrolyzed by EndoS induced suppression of local immune complex (IC)-mediated arthritis. A small amount (1 µ
Introduction: The complement system is essential for an adequate immune response. Much attention has been given to the role of complement in disease. However, to better understand complement in pathology, it is crucial to first analyze this system under different physiological conditions. The aim of the present study was therefore to investigate the inter-individual variation in complement activit
Around 100,000 refugees are resettled to dozens of countries from conflict zones every year. While there is growing evidence that the initial placement of refugee families profoundly affects their lifetime outcomes, there have been few attempts to optimize resettlement destinations within host countries. We describe how machine learning and integer optimization can be used to empower resettlement
BACKGROUND: Thylakoid-stabilised emulsions have been reported to possess satiety-promoting effects and inhibit pancreatic lipase-colipase activity in vitro, which prompted the investigation of their interfacial properties.RESULTS: Thylakoid membranes isolated from spinach were used as an emulsifier/stabiliser in oil (triglyceride)-in-water emulsions. Emulsions were characterised with respect to dr
Objective: Primary adrenal insufficiency [Addison's disease (AD)] is rare, and systematic studies are few, mostly conducted on small patient samples. We aimed to determine the clinical, immunological, and genetic features of a national registry-based cohort. Design: Patients with AD identified through a nationwide search of diagnosis registries were invited to participate in a survey of clinical f
BACKGROUND: It is difficult to estimate the diagnostic accuracy of biopsy for prostate cancer because men with negative biopsy do not undergo radical prostatectomy and thus have no confirmation of biopsy findings. METHODS: We performed 18-core needle biopsies on autopsy prostates from 164 men who had no history of prostate cancer. Six-core biopsies were taken from each of the mid peripheral zone (
A plethora of peptides are generated intracellularly, and most peptide-human leukocyte antigen (HLA)-I interactions are of a transient, unproductive nature. Without a quality control mechanism, the HLA-I system would be stressed by futile attempts to present peptides not sufficient for the stable peptide-HLA-I complex formation required for long term presentation. Tapasin is thought to be central
The complement system plays an important role in eliminating invading pathogens. Activation of complement results in C3b deposition (opsonization), phagocytosis, anaphylatoxin (C3a, C5a) release, and consequently cell lysis. Moraxella catarrhalis is a human respiratory pathogen commonly found in children with otitis media and in adults with chronic obstructive pulmonary disease. The species has ev
This work deals with the problem of direction of arrival estimation of interferometric synthetic aperture radar (InSAR) signals in presence of layover. The focus here is on realistic acquisition systems with a low number of phase centres and nonuniform array geometry. An interpolated array approach is proposed, in order to apply spectral estimation techniques designed for uniform linear arrays. In
The purpose of the paper is to apply system identification methods to study spatial and temporal propagation of atrial activation along coronary sinus (situated in the posterior left part of the heart, in the groove between left atrium and left ventricle) during paroxysmal atrial fibrillation using data recorded from 7 different patients. Furthermore, interatrial mechanisms of impulse conduction c
This paper presents a study with the intent to examine the opportunities provided by creating and using simulation models of software development processes. A model of one software development project was created through means of system dynamics, with data collected from documents, interviews and observations. The model was simulated in a commercial simulation tool. The simulation runs indicate th
This thesis, which is based on five original papers, covers different aspects of antibody specificity and diversity, with the overall goal to understand the makeup of antibody repertoires and their functionality as they occur in vivo or as they are developed in the laboratory. Besides their importance in the adaptive immune response, antibodies have emerged as an invaluable tool in applications r
This dissertation is a study of the Christian thematics in the novels of Christine Falkenland. It has two basic aims. First, to demonstrate how Christine Falkenland writes herself into, and becomes a distinct voice in, a Christian literary tradition, while simultaneously breaking with this tradition by staging and portraying modern people’s questioning of the Christian worldview. Second, to uncove
Five students of a rescue training school cycled at 50 W for 20 minutes at 20 °C before walking up to 30 minutes in a climatic chamber at 55 °C and 30 % relative humidity. Four different types of clothing ensembles were used differing in terms of thickness and thermal insulation value were tested on separate days. All subjects completed 28-30 minutes in light clothing, but quitted after 20-27 minu
The aim of this study was to assess the ability of different mouse diets to sustain an H. pylori infection in BALB/cA mice. Four commercially available mouse diets were compared. Experiment 1: Mice were fed the four diets for seven days before infection, infected three times at two-day intervals with 0.1 ml of 10(9) colony-forming units/ml H. pylori cells. H. pylori strains (n = 4) were cultured o
The main purpose of this dissertation is to see how proponents of diaconia justified the establishment of three Swedish diaconal institutions: Diaconissanstalten 1851 (The Institution for Deaconesses, Stockholm, now Ersta diakonissällskap/Ersta Association for Diaconal Work), Stockholms Stadsmission 1853 (The Stockholm City Mission) and Svenska Diakonanstalten 1898 (The Swedish institution for Dea
The innate immune system relies to a great deal on the interaction of pattern recognition receptors with pathogen- or damage-associated molecular pattern molecules. Extracellular histones belong to the latter group and their release has been described to contribute to the induction of systemic inflammatory reactions. However, little is known about their functions in the early immune response to an
Polymeric beta-cyclodextrin (beta CD) films tunable with respect to thickness and beta CD content were prepared in order to develop a suitable platform, allowing for inclusion of nonpolar guest molecules in the beta CD cavity, while suppressing nonspecific protein adsorption. The beta CD films were synthesized from linear beta CD dextran polymers, and grafted onto silicon oxide surfaces by "click"
