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BACKGROUND: Lynch syndrome is a rare familial cancer syndrome caused by pathogenic variants in the mismatch repair genes MLH1, MSH2, MSH6, or PMS2, that cause predisposition to various cancers, predominantly colorectal and endometrial cancer. Data are emerging that pathogenic variants in mismatch repair genes increase the risk of early-onset aggressive prostate cancer. The IMPACT study is prospect
Background: Due to a large variety in treatment outcomes reported in therapeutic trials and lacking patient-relevant outcomes, it is hard to adequately compare and improve current therapies for patients with capillary malformations (CMs). The Core Outcome Set for Capillary Malformations (COSCAM) project aims to develop a core outcome set (COS) for use in future CM trials, in which we will first de
Allogeneic hematopoietic cell transplantation (allo-HCT) is an effective immunotherapeutic approach for various hematologic and immunologic ailments. Despite the beneficial impact of allo-HCT, its adverse effects cause severe health concerns. After transplantation, recognition of host cells as foreign entities by donor T cells induces graft-vs.-host disease (GVHD). Activation, proliferation and tr
Background Juvenile idiopathic arthritis (JIA) is an umbrella term of inflammatory joint diseases in children. Oligoarthritis is the most common form in the Western world, representing roughly 60% of all patients. Monocytes and macrophages play an important role in adult arthritides, but their role in oligoarticular JIA is less studied. Polarization highly influences monocytes’ and macrophages’ ef
Reliable assessment of self-reported immune function is essential for identifying at-risk populations, monitoring public health interventions and informing global health strategies. Yet, current instruments are imprecise and lack cross-cultural validity. This study aimed to assess the cross-cultural validity of the 7-item Immune Status Questionnaire (ISQ). The Partial Credit Rasch model was applie
Despite recent progress within the field of immuno-oncology, immune suppression in the tumor microenvironment, defective antigen presentation, and low levels of tumor-specific T cells are key limitations of current cancer immunotherapies. CD40-targeting immunotherapies hold promises for addressing these limitations across solid tumors. Here, we describe ATOR-4066, a bispecific antibody that target
Academic staff | LTH, Faculty of Engineering Skip to main content We use cookies and other tracking technologies to improve the user experience on our website, to show you personalised content and targeted ads, and to analyse our website traffic. Cookie Policy . Essential cookies These cookies are necessary for the website to function and cannot be turned off in our systems. These cookies do not s
https://www.lth.se/english/cee/about-cee/staff/academic-staff/ - 2026-06-09
Besöksadress LUX, Lunds universitet, Helgonavägen 3, Lund, Postadress Box 192, 221 00 Lund Telefon 046-222 95 89, Fax 046-222 32 28 E-post Martin.Lembke@ctr.lu.se, Internet http://www.teol.lu.se/person/MartinLembke Husstyrelsen för SOL-husen Närvarande ledamöter Fabian Beijer Sektion 4, SOL fr.o.m. § 79 Viktoria Hörnlund HT-biblioteken Maria Persson SOL Karin Salomonsson kanslichef Charlotte Tornb
https://www.ht.lu.se/fileadmin/user_upload/HT-intra/templates/protokoll_SOL-husen_2023.pdf - 2026-07-11
Modelling Ground Vibrations in Abaqus using Python Master’s Dissertation Structural Mechanics Report TV SM -5278 A RG ETA JU PO LLI M O D ELLIN G G R O U N D V IB R A TIO N S IN A B A Q U S U SIN G PY TH O N ARGETA JUPOLLI MODELLING GROUND VIBRATIONS IN ABAQUS USING PYTHON DEPARTMENT OF CONSTRUCTION SCIENCES DIVISION OF STRUCTURAL MECHANICS ISRN LUTVDG/TVSM--25/5278--SE (1-74) | ISSN 0281-6679 MAS
https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5278.pdf - 2026-07-11
CONTEXT: People viewed as "overweight" or "obese" are vulnerable to weight-based discrimination, creating inequities and adverse health outcomes. Given the high rates of obesity recorded globally, studies documenting weight discrimination in multiple countries, and an absence of legislation to address this form of discrimination, research examining policy remedies across different countries is nee
The usual practice to measure the zero sequence voltage on the D-side of a transformer is to use three voltage transformers (VT), each of them connected between each phase and earth on the primary side and broken-delta connected on the secondary side. In this paper a method is presented for the estimation of the zero sequence voltage on the D-side of a Dy transformer by the use of only one VT conn
The generation of toxic oligomers during the aggregation of the amyloid-beta (A beta) peptide A beta 42 into amyloid fibrils and plaques has emerged as a central feature of the onset and progression of Alzheimer's disease, but the molecular pathways that control pathological aggregation have proved challenging to identify. Here, we use a combination of kinetic studies, selective radiolabeling expe
A polymerase chain reaction (PCR)-based assay using primers against the hepatitis C core gene has been described [Okamoto et al. (1992a): Journal of General Virology 73:673-679]. Within the two major HCV genotypes 1 and 2, the Okamoto system identifies two subtypes each (1a, 1b and 2a, 2b, respectively). Typing is achieved by a primary PCR with consensus primers followed by a nested PCR with type
We present deep Hubble Space Telescope ACS observations of the G1 clump, a distinct stellar overdensity lying at similar to 30 kpc along the southwestern major axis of M31, close to the G1 globular cluster ( from the work of Ferguson and coworkers). Our well-populated color-magnitude diagram reaches similar to 7 mag below the red giant branch tip with 90% completeness, and allows the detection of
Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the glucosidase, beta, acid (GBA) gene that encodes the lysosomal enzyme glucosylceramidase (GCase). GCase deficiency leads to characteristic visceral pathology and, in some patients, lethal neurological manifestations. Here, we report the generation of mouse models with the severe neuronopathic form o
Research on the biology of the tumor stroma has the potential to lead to development of more effective treatment regimes enhancing the efficacy of drug-based treatment of solid malignancies. Tumor stroma is characterized by distorted blood vessels and activated connective tissue cells producing a collagen-rich matrix, which is accompanied by elevated interstitial fluid pressure (IFP), indicating a
This thesis has evaluated the immunological- and epidemiological aspects of human papillomavirus transmission dynamics and its effect on circumcision. Effective prophylactic vaccines are based on type-specific neutralizing antibodies. A major neutralizing epitope is defined by the monoclonal antibody H16.V5. To investigate the importance of this epitope for overall immunogenicity of HPV16, we en
Many popular direction-of-arrival (DOA) estimators rely on the fact that the array response vector of the array is Vandermonde, for example, that of a uniform linear array (ULA). Array interpolation is a preprocessing technique to transform the array response vector of a planar array of arbitrary geometry to that of a ULA over an angular sector. While good approximation within the target sector is
