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Young children with visual impairments tend to engage less with their surroundings, limiting the benefits from activities at school. We investigated novel ways of using sound from a bracelet, such as speech or familiar noises, to tell children about nearby people, places and activities, to encourage them to engage more during play and help them move independently. We present a series of studies, t
Cross-laminated timber (CLT) as a prime example of an innovative product within the field of civil engineering has over the recent years attracted attention of the construction industry and engineers around the world. As a natural composite with different orientation of layers in addition to anisotropic properties of wood, CLT can be a challenging material in predictive numerical modelling. This i
Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a robust, but poorly understood, neuroinflammatory response that contributes to the long-term pathology. We used single-nuclei RNA sequencing (snRNA-seq) to study transcriptomic changes in different cell populations in human brain tissue obtained acutely after severe, life-threatening TBI. This revealed a un
We examined the effect of GH supplementation on the psychological capacity and sense of well-being in 36 patients with adult-onset GH deficiency (GHD). Recombinant human GH was given in a 21-month cross-over, double blind trial, and quality of life was assessed by using three self-rating questionnaires: the Hopkins Symptom Check List (HSCL), the Nottingham Health Profile (NHP), and the Psychologic
Importance: Blood phosphorylated tau (p-tau) and amyloid-β peptides (Aβ) are promising peripheral biomarkers of Alzheimer disease (AD) pathology. However, their potential alterations due to alternative mechanisms, such as hypoxia in patients resuscitated from cardiac arrest, are not known. Objective: To evaluate whether the levels and trajectories of blood p-tau, Aβ42, and Aβ40 following cardiac a
Antimicrobial resistance (AMR) threatens global public health and modern surgical medicine. Expression of β-lactamase genes is the major mechanism by which pathogens become antibiotic resistant. Pathogens expressing extended spectrum β-lactamases (ESBL) and carbapenemases (CP) are especially difficult to treat and are associated with increased hospitalization and mortality rates. Despite considera
Context: The previously reported absence of 65-kDa glutamate decarboxylase antibody (GAD65Ab)-specific antiidiotypic antibodies (anti-Id) in type 1 diabetes (T1D) patients at clinical onset could be due to an inability to mount an antibody response to GAD65Ab or a longitudinal decline in anti-Id levels. Objective and Design: We investigated anti-Id levels in longitudinal samples obtained from T1D
Chronic immune stimulation such as Helicobacter pylori (hp) infection, Sjögren's syndrome or coeliac disease may initiate non-Hodgkin lymphoma (NHL). The opposite (appearance of autoimmunity) has also been reported. The aim of this study was to describe the pattern of these immune markers in patients with lymphoid malignancies. Sera from 96 patients with NHL (median age 72, range 38-88, F/M 41/55)
S100A8 plays a critical role in the pathogenesis of several inflammatory diseases and multiple types of cancer. Therefore, targeting the S100A8 function may alleviate the pathogenic process in various diseases. Here, specific single-chain variable fragment (scFv) antibodies targeting recombinant S100A8 (rS100A8) were selected by phage display technique and characterized using cDNA sequencing, immu
Schistosoma japonicum (S. japonicum) infection and soluble egg antigens (SEA) can induce various immune responses, including the generation of IL-10-producing regulatory B cells (Bregs). This study investigated the dynamic changes and induction mechanisms of Bregs during S. japonicum infection. We demonstrated that CD19+IL-10+Bregs and CD19+Tim-1+ Bregs secreting IL-10 gradually increased from 6 t
Radiotherapy (RT) with concurrent chemotherapy is the standard of care for squamous-cell carcinoma of the anal canal (SCCAC), achieving favorable results in terms of local control and overall survival. However, locoregional failure remains common despite advances such as intensity-modulated radiotherapy (IMRT), which reduces toxicity but has limitations. Despite the benefits of IMRT, frequent and
BACKGROUNDAmyloid beta (Aβ) antibodies are the only therapies to slow cognitive decline in Alzheimer's disease (AD). Yet the sites where antibodies engage Aβ in the brain and mechanisms that lower Aβ are not fully understood. Defining Aβ antibody localizations in the brain is essential to understand how immunotherapy is beneficial for AD.METHODSN-terminal Aβ antibody 6E10 was injected via three di
Much of the hype about AI exploits the fact that human cognition, language, and categorization rely on imaginative scaffolding. Some degree of metaphor and conceptual borrowing should not be seen as a methodological failure. Law does not meet AI as a blank slate. It reaches for metaphors and other imaginative patterns that make the unfamiliar legible, channeling attention toward certain features a
Popular Abstract in Swedish Denna avhandling är en studie av en grupp cypriska stenskulpturer som ställdes upp som votivgåvor i öns tempel och helgedomar under 500-talet f.Kr. Det som utmärker gruppen är att de bär cypriska versioner av karakteristisk egyptisk klädedräkt och smycken. För att kunna svara på frågor som varför denna egyptiserande votivtyp dedicerades på ön, varifrån impulserna kom ocThis thesis is a study of a particular limestone votive statuary type which was dedicated in the sanctuaries on Cyprus during the entire 6th century B.C. Common to the group of figures is that they are wearing a Cypriote version of an Egyptian-type outfit, including characteristic Egyptian royal headgear and jewelry. In order to be able to answer questions on the origin of the Egyptianizing iconog
Speaking in poor acoustic conditions constitutes a risk factor for voice disorders. This study investigated how speaker’s comfort and vocal effort were affected during short speech tasks in four different room acoustic configurations. Voice recordings of the speech tasks and self-evaluations of the speaker’s comfort were collected from 15 participants in four room acoustic configurations as part o
