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Background: The duration of protection provided by varicella vaccines is unclear. We assessed the 10-year vaccine efficacy of two doses of a combined measles-mumps-rubella-varicella vaccine (MMRV), one live attenuated varicella vaccine (V) dose given after one measles-mumps-rubella vaccine (MMR) dose (MMR + V), versus two MMR doses (control vaccine) for the prevention of confirmed varicella. Metho

During the last ten years or so, much effort has been spent on developing software architecture by analogy with hardware architecture from where the idea seems to originate. Much of the work has been devoted to specifying standard program units, called components, and their connections. The architecture is then the specific organization of these components and connections. In this paper, I suggest

We describe an automatic system for pose-estimation from a single image in a city scene. Each building has a model consisting of a number of parallel planes associated with it. The homographies for the best match of the planes to the image is estimated automatically for each of the possible buildings. We show how the estimation of the homographies can be done effectively by reducing the search spa

The malaria parasites (Apicomplexa: Haemosporida) of birds are believed to have diversified across the avian host phylogeny well after the origin of most major host lineages. Although many symbionts with direct transmission codiversify with their hosts, mechanisms of species formation in vector-borne parasites, including the role of host shifting, are poorly understood. Here, we examine the hosts

Popular Abstract in Swedish Grupp B streptokocker (GBS) är den vanligaste orsaken till blodförgiftning, lunginflammation och hjärnhinneinflammation i nyföddhetsperioden. Ungefär en fjärdedel av alla kvinnor är koloniserade (bärare) genitalt av GBS under graviditeten och förlossningen. Hälften av barnen till dessa kvinnor blir smittade av bakterien i samband med födseln, men bara en liten del av deInfection with group B streptococcus (GBS), an encapsulated bacterium, is an important cause of neonatal morbidity and mortality. Capsular polysaccharides and cell surface proteins of GBS are candidate antigens for development of a human GBS vaccine. Proteins have many advantages as vaccine antigens. The majority of the neonatal infections are caused by strains of capsular serotypes Ia, Ib, II, II

DNA-dependent protein kinase (DNA-PK) is a holoenzyme consisting of a regulatory subunit, the heterodimeric Ku70/86, and a catalytic subunit known as DNA-dependent protein kinase catalytic subunit (DNA-PKcs). DNA-PK takes part in a number of cellular functions including growth control, immunoglobulin gene rearrangement and DNA repair. The Ku86 subunit of DNA-PK has been reported to exist in human

The paper presents the major findings from the three evacuation experiments being part of the Swedish METRO research project. In the evacuation experiments; the small, medium and full-scale experiments, investigations were carried out with the purpose to study how train passengers safely can be evacuated in case of a fire emergency. In addition to determine flow rates, the walking velocity and wal

The therapeutic potential of glial cell line-derived neurotrophic factor ( GDNF) for Parkinson's disease is likely to depend on sustained delivery of the appropriate amount to the target areas. Recombinant adeno-associated viral vectors ( rAAVs) expressing GDNF may be a suitable delivery system for this purpose. The aim of this study was to define a sustained level of GDNF that does not affect the

Popular Abstract in Swedish Universitet och högskolor har i kölvattnet av ett framväxande kunskapssamhället hamnat under kraftig institutionell press från en förändrad nationell forskningspolitik, de forskningsfinansierande aktörernas förändrade strategier och en snabb och omvälvande vetenskaplig dynamik. Avhandlingen handlar om hur Lunds universitet har reagerat på och hanterat dessa förändringspIn the wake of an emerging knowledge society, universities around the world have come under severe institutional pressure from changing national research policies, financing organizations´ new strategies and turbulent research dynamics. This study examines how Lund University in Sweden manages these institutional pressures. The study explores how the university leadership ? rector and the governin

The gastrointestinal mucosa is one of the most rapidly proliferating tissues in the body, and serves as a barrier to luminal bacteria and toxins. Enteral nutrition, luminal fiber and probiotics are of crucial importance for the integrity of this barrier. We examined the potential beneficial effects of lactobacilli and fiber on methotrexate-induced enterocolitis and radiation-induced intestinal inj

The epithelia are the avascular layers of cells that cover the environment-exposed surfaces of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the selective expression of adhesion molecules and chemokine receptors on T cells. These bind to counter-receptors and to chemokines expressed by epithelial cells. Recently, there has been an advance in our under

Mycobacterium tuberculosis (Mtb) employs various strategies to modulate host immune responses to facilitate its persistence in macrophages. The Mtb cell wall contains numerous glycoproteins with unknown role in pathogenesis. Here, by using concavalinA and LC-MS analysis we identified a novel mannosylated glycoprotein phosphoribosyl- transferase, encoded by the Rv3242c, from Mtb cell walls. Homolog

A high energy supply and appropriate amount of polyunsaturated fatty acids is crucial for proper growth and development in neonates. The capacity for fatty acid absorption in newborns is however hampered due to an undeveloped pancreatic function combined with a low bile output. This seems in particular to limit fatty acid absorption in babies given infant formulas. Since interaction between the li

This paper explores the concept of peer-to-peer learning (P2PL) in the context of North-European small-scale forest owners. The aim is to develop a framework for initiating new and evaluating already existing forest owners’ P2PL communities. Design: Previous studies of peer-learning are used to determine and justify eight dimensions for forest owners’ P2PL. To demonstrate and test the operability

We introduce the 'Engineering Dwarfs at Galaxy Formation's Edge' (EDGE) project to study the cosmological formation and evolution of the smallest galaxies in the Universe. In this first paper, we explore the effects of resolution and sub-grid physics on a single low-mass halo (Mhalo = 109M⊙), simulated to redshift z = 0 at amass and spatial resolution of ∼ 20 M⊙ and ∼3 pc. We consider different st

Microglia are activated in many neurological diseases and have been suggested to play an important role in the development of affective disorders including major depression. To investigate how microglial signaling regulates mood, we used bidirectional chemogenetic manipulations of microglial activity in mice. Activation of microglia in the dorsal striatum induced local cytokine expression and a ne