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The master regulator of neuroendocrine differentiation, achaete-scute complex homolog 1 (ASCL1) defines a subgroup of lung adenocarcinoma. However, the mechanistic role of ASCL1 in lung tumorigenesis and its relation to the immune microenvironment is principally unknown. Here, the immune landscape of ASCL1-positive lung adenocarcinomas was characterized by immunohistochemistry. Furthermore, ASCL1
The risk for type 1 diabetes is strongly associated with HLA-DQ and the appearance of beta cell autoantibodies against either insulin, glutamate decarboxylase (GAD65), insulinoma-associated protein-2 (IA-2), or zinc transporter 8 (ZnT8). Prolonged exposure to autoantibodies may be related to T cell exhaustion known to occur in chronic infections or autoimmune disorders. It was hypothesized that au
Type-2 diabetes (T2D) is a global disease caused by the inability of pancreatic β-cells to secrete adequate insulin. However, the molecular mechanisms underlying the failure of β-cells to respond to glucose in T2D remains unknown. Here, we investigated the relative contribution of UDP-glucose (UDP-G), a P2Y14-specific agonist, in the regulation of insulin release using human isolated pancreatic is
I och med Hu Jintaos och Wen Jiabaos tillträde till makten har den kinesiska regeringens fokus kommit att flyttas från ren ekonomisk utveckling till att i högre grad än tidigare fokusera på att minska klyftorna mellan stad och landsbygd. Denna uppsats undersöker några av de problem som centralregeringen ser på landsbygden idag, samt några av de lösningar som presenterats. I undersökningen av situaSince Hu Jintao and Wen Jiabao took office the focus of the Chinese government has been less on pure economic development than before and more on developing the countryside. This paper investigates some of the problems the central government sees in the countryside as well as some of their solutions to those problems. The book The Grain People: Will China’s Villages Disappear? (Liangmin－Zhongguo n
Introduction: HIV guidelines recommend switching from a three-drug regimen (3DR) to dolutegravir + lamivudine (DTG+3TC) for eligible individuals. This retrospective national cohort study used Swedish InfCareHIV registry data to evaluate long-term outcomes of adults with HIV RNA <50 copies/ml who switched to DTG+3TC or a guideline-recommended 3DR between July 2019 and May 2023 in routine clinical c
Moisture‐induced deterioration is critical to building envelope durability in cold and temperate climates. To propose a new framework for selecting moisture design periods (MDPs) in Swedish building assemblies that capture sever moisture conditions more accurately, this paper evaluates different methods for producing MDPs. Using a 30‐year historical weather dataset as a benchmark, we compared simu
Digitala D2C-företag i traditionellt fysiska branscher kan etablera en tydlig nisch, men möter nya utmaningar när affärsmodellen ska skalas till fler kundsegment. Detta examensarbete undersöker hur ett svenskt digitalt D2C-företag inom målarfärgsbranschen kan vidareutveckla en validerad, nischad och digital affärsmodell för att nå nya kundsegment på den svenska marknaden. Studien genomförs som enDigital D2C companies in traditionally physical retail can establish a clear niche, but face new challenges when the business model is scaled to broader customer segments. This thesis explores how a Swedish company in the paint industry can further develop a validated, niche-oriented, and digital business model to reach new customer segments in the Swedish market. The study is conducted as a case
Arrhythmogenic right ventricular cardiomyopathy (ARVC) and cardiac sarcoidosis (CS) can show significant overlap in their clinical presentation. Differentiation between both is crucial for optimal patient management. Aim of this study is to develop an ECG-based machine learning model to distinguish between ARCV and CS patients. The study population included 100 patients (50 with ARCV and 50 with C
Objectives: Positive resection margins after breast-conserving surgery (BCS) most often demands a repeat surgery. To preoperatively identify patients at risk of positive margins, a multivariable model has been developed that predicts positive margins after BCS with a high accuracy. This study aimed to externally validate this prediction model to explore its generalizability and assess if additiona
This article conducts a multi-scalar analysis of the dynamics between secularism and religion in contemporary Sweden and highlights a growing divide between them, in the wake of neoliberal reconfigurations of the welfare state and a stronger religious pluralism in public space. Through an analysis of the public debate around conversion attempts and state funding for religious organizations, we exp
Esophageal lesions are common findings in disorders of the digestive tract in patients living with HIV, the most typical symptoms being odynophagia and/or dysphagia. This article provides a narrative review of the spectrum of esophagitis in patients living with HIV, focusing on fungal, viral, bacterial and non-infectious etiologies, as well as co-infections with viral hepatitis viruses. The articl
Introduction: Antibodies targeting the blood-stage of Plasmodium falciparum play a critical role in naturally acquired immunity to malaria by limiting blood-stage parasitemia. One mode of action of antibodies is the direct inhibition of merozoite invasion of erythrocytes through targeting invasion ligands. However, evasion of inhibitory antibodies may be mediated in P. falciparum by switching betw
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is primarily known as a respiratory disease. The continued study of the disease has shown that long-term COVID-19 symptoms include persisting effects of the virus on the brain when the infection is over, possibly even leading to neurodegeneration. However, the exact mechanisms of
BACKGROUND: Excessive dietary salt intake is associated with elevated blood pressure and damage to organs including the heart, vasculature, and kidneys. Women are more prone to salt-sensitive hypertension, yet preclinical studies often focus on men.METHODS: To examine sex-specific responses to chronic salt loading, male and female C57Bl6/J mice were fed a high-salt diet (HSD; 8% NaCl) from 7 to 14
OBJECTIVES: Ultra-high dose rate irradiation (UHDR) has been shown to spare normal tissue in various model systems. This study evaluates its potential to sterilize cancer cells using spheroid tumor models.METHODS: Spheroids from glioblastoma (U87), hypopharyngeal squamous cell carcinoma (two sizes, FaDusmall and FaDularge) and breast adenocarcinoma (T47D) cells were irradiated with electron beams
Ischemia-reperfusion injury in transplantation remains a significant clinical challenge with regard to both short-term and long-term complications. In this study, we developed a new amphiphilic construct, polyethylene glycol (PEG)-conjugated lipids (PEG-LIPIDs), to be administered ex vivo intra-arterially to procured porcine kidney allografts before reperfusion. The aim was to create a protective
This paper reports on the educational model undertaken in two specialized summer schools in Denmark (2022) and Poland (2023) on daylighting in buildings. As a part of a European educational initiative, these schools aimed to deepen participants' understanding of the impact of daylight on building design. The programme, a collaborative effort between universities, companies, associations, professio
Myeloid cells, such as monocytes, are central in the immune response to infections. However, limited knowledge exists regarding the inflammatory response to Gram-positive anaerobic cocci (GPAC). To explore the ability of GPACs to induce monocyte activation, we compared two GPAC species, Parvimonas micra and Peptoniphilus harei, with E. coli, a major cause of bloodstream infections. We stimulated w
Environmental Building Certification (EBC) assessments, involving modelling, simulation, and grading calculation, are often time-consuming, prompting a need for streamlining. This investigation assesses existing Building Energy Modelling (BEM) workflows for Swedish context of EBC, focusing on extracting building geometry from Autodesk Revit with minimal information losses, and considering both low
