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Among the responders to microbial invasion, neutrophils represent the earliest and perhaps the most important immune cells that contribute to host defense with the primary role to kill invading microbes using a plethora of stored anti-microbial molecules. One such process is the production of reactive oxygen species (ROS) by the neutrophil enzyme complex NADPH-oxidase, which can be assembled and a
Background: All available recommendations about the management of antithrombotic therapies (ATs) in patients who experienced traumatic brain injury (TBI) are mainly based on expert opinion because of the lack of strength in the available evidence-based medicine. Currently, the withdrawal and the resumption of AT in these patients is empirical, widely variable, and based on the individual assessmen
This article explores the musical performances, aesthetics, and multi-situated reception of the Indonesian electronic dance music in Europe and Indonesia, focusing on the duo Gabber Modus Operandi (GMO). Since their first international tour entitled “Trance Against the Machine” in 2019, the duo has gained significant attention, especially in Europe, because they are seen as part of a “seismic shif
Aim of this contribution is to demonstrate how digital methods, in combination with traditional sources, can effectively contribute to reconstruct a narrative of the past based on a sensory account of a few coastal landscapes in Northwestern Etruria as they were perceived and described by ancient authors. A few passages by Strabo (Geogr. 5.2.5, 222C, Augustan period) and Rutilius Namatianus (de re
Juvenile idiopathic arthritis (JIA) is a heterogenous inflammatory joint disease and the most commonrheumatic disease in children. Oligoarticular JIA (oJIA) is the major subgroup, which mainly affects fewand large joints, such as the knee. The immunological processes and key players driving inflammationwithin the affected joints are not well characterised. Research has primarily focused on adaptiv
Thermal performance curves (TPCs) are intended to approximate the relationship between temperature and fitness, and are commonly integrated into species distributional models for understanding climate change responses. However, TPCs may vary across traits because selection and environmental sensitivity (plasticity) differ across traits or because the timing and duration of the temperature exposure
Aerococcus urinae is an emerging pathogen that causes urinary tract infections, bacteremia and infective endocarditis. The mechanisms through which A. urinae cause infection are largely unknown. The aims of this study were to describe the surface proteome of A. urinae and to analyse A. urinae genomes in search for genes encoding surface proteins. Two proteins, denoted Aerococcal surface protein (A
While gene flow can reduce the potential for local adaptation, hybridization may conversely provide genetic variation that increases the potential for local adaptation. Hybridization may also affect adaptation through altering sexual dimorphism and sexual conflict, but this remains largely unstudied. Here, we discuss how hybridization may affect sexual dimorphism and conflict due to differential e
The protein parkin, encoded by the PARK2 gene, is vital for mitochondrial homeostasis, and although it has been implicated in Parkinson’s disease (PD), the disease mechanisms remain unclear. We have applied mass spectrometry-based proteomics to investigate the effects of parkin dysfunction on the mitochondrial proteome in human isogenic induced pluripotent stem cell-derived neurons with and withou
Undifferentiated pleomorphic sarcoma (UPS) is a highly aggressive soft tissue tumor. A subset of UPS is characterized by a CITED2–PRDM10 or a MED12–PRDM10 gene fusion. Preliminary data suggest that these so-called PRDM10-rearranged tumors (PRT) are clinically more indolent than classical high-grade UPS, and hence important to recognize. Here, we assessed the spectrum of accompanying mutations and
IN UNIVERSITY ENVIRONMENT OF MINSK S . N . B u r o v a GENDER STEREOTYPES GENDER STEREOTYPES IN UNIVERSITY ENVIRONMENT OF MINSK Minsk «Unipack» 2015 GENDER STEREOTYPES IN UNIVERSITY ENVIRONMENT OF MINSK Minsk «Unipack» 2015 Burova S.N., Associate Professor, Department of Sociology Belarusian State University, Candidate of Sciences in Law, Member of the National Council on Gender Policy under the C
https://rwi.lu.se/app/uploads/2020/08/en_burova_gender-stereotypes-1.pdf - 2026-07-21
This thesis investigates the financial viability of green hydrogen production for mobility applications across four European countries: Germany, Norway, Denmark and Spain. Given the rising importance of hydrogen in hard-to-electrify sectors such as (heavy-duty) transport, the study focuses on understanding how system design and local energy conditions influence the Levelised Cost of Hydrogen (LCOH
This thesis argues that the escalating and protracted violence in Mexico, commonly known as the ‘war on drugs,’ constitutes a non-international armed conflict (NIAC) under international humanitarian law (IHL), calling for a formal application of this legal framework. Despite its devastating humanitarian consequences, the conflict is often mischaracterised within a law enforcement paradigm, contrib
This thesis examines the degree to which the comparator test and detriment test, as the two prevailing tests for direct discrimination in Australia, are compatible with the Convention on the Rights of Persons with Disabilities (‘CRPD’). Drawing on the Committee on the Rights of Persons with Disabilities’ evolutive interpretation of the CRPD, this thesis derives two normative requirements for legis
It is becoming clear that the cognition of a species plays an important role in successful conservation, with cultural processes being a fundamental part of this. However, in contrast to mammals and birds, very little is known about cultural processes (and the social learning that underlies these) in reptiles. Here, we summarize the current state of knowledge, consider why this information is so l
Purpose: To compare the performance of targeted temperature management (TTM) at 33 °C using intravascular (IC) vs. surface-cooling (SFC) devices after out-of-hospital cardiac arrest (OHCA). Methods: A post hoc analysis including OHCA patients randomized to hypothermia in the TTM2-trial (NCT02908308) comparing hypothermia with normothermia. The main outcome was cooling performance, defined as the p
