Filetype
BACKGROUND: Plasma biomarkers associated with Alzheimer's disease could improve prognostic assessment for people with Down syndrome in both clinical practice and research settings. We aimed to identify the plasma biomarkers that most accurately predict longitudinal changes in Alzheimer's disease-related pathology and cognitive functioning in individuals with Down syndrome.METHODS: This longitudina
BACKGROUND: Transportation noise has been linked with cardiometabolic outcomes, yet whether it is a risk factor for atrial fibrillation (AF) remains inconclusive. We aimed to assess whether transportation noise was associated with AF in a large, pooled Nordic cohort.METHODS: We pooled data from 11 Nordic cohorts, totaling 161,115 participants. Based on address history from five years before baseli
BACKGROUND: Lymphatic disorders such as protein-losing enteropathy, plastic bronchitis, and chylothorax are important complications of the Fontan circulation and ultimately result in an increased risk of early death. Several European centers are now performing lymphatic procedures. The aim of this study is to map the extent of these lymphatic disorders and treatments provided across European pedia
Objective: To build on Achenbach, Rescorla, and Ivanova (2012) by (a) reporting new international findings for parent, teacher, and self-ratings on the Child Behavior Checklist, Youth Self-Report, and Teacher's Report Form; (b) testing the fit of syndrome models to new data from 17 societies, including previously underrepresented regions; (c) testing effects of society gender, and age in 44 societ
The onset of inflammation is associated with reactive oxygen species and oxidative damage to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG and because Ogg1-deficient mice are resistant to acute and systemic inflammation, we hypothesized that OGG1 inhibition may represent a strategy for the prevention and treatment of inflam
BACKGROUND: Although rare in the general population, highly penetrant germline mutations in CDKN2A are responsible for 5-40% of melanoma cases reported in melanoma-prone families. We sought to determine whether MELPREDICT was generalizable to a global series of melanoma families and whether performance improvements can be achieved.METHODS: 2,116 familial melanoma cases were ascertained by the inte
BACKGROUND: Abiraterone acetate plus prednisone significantly improved radiographic progression-free survival compared with placebo plus prednisone in men with chemotherapy-naive castration-resistant prostate cancer at the interim analyses of the COU-AA-302 trial. Here, we present the prespecified final analysis of the trial, assessing the effect of abiraterone acetate plus prednisone on overall s
Aberrant stem cell-like gene regulatory networks are a feature of leukaemogenesis. The ETS-related gene (ERG), an important regulator of normal haematopoiesis, is also highly expressed in T-ALL and acute myeloid leukaemia (AML). However, the transcriptional regulation of ERG in leukaemic cells remains poorly understood. In order to discover transcriptional regulators of ERG, we employed a quantita
Purpose: Humoral immunity proteins—immunoglobulins, complement proteins, and antimicrobial peptides—have key antimicrobial and immunomodulatory functions in sepsis. We hypothesised that their circulating levels are lower in non-survivors, potentially resulting in impaired bacterial clearance and persistent or recurrent infections. Methods: We performed a systematic review and meta-analysis evaluat
In pancreatic ductal adenocarcinoma (PDAC), the dense desmoplastic stroma and insufficient infiltrating T cells represent a significant barrier to effective immunotherapy. In this phase I, dose-escalation study, previously registered at the Dutch Trial Register and later on at ClinicalTrial (NCT05650918), we administer an autologous dendritic cell (DC) vaccine (MesoPher) with an agonistic CD40-spe
Background: Platelet transfusions are given to preterm infants with severe thrombocytopenia aiming to prevent haemorrhage. The PlaNeT2/MATISSE trial revealed higher rates of mortality and/or major bleeding in preterm infants receiving prophylactic platelet transfusions at a platelet count threshold of 50 × 109/L compared to 25 × 109/L. The extent to which this evidence has been incorporated into c
There is limited evidence on the association between dietary folate intake and the risk of breast cancer (BC) by hormone receptor expression in the tumors. We investigated the relationship between dietary folate and BC risk using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). A total of 367993 women age 35 to 70 years were recruited in 10 European countries. Dur
Insufficient oxygen and nutrient supply often restrain solid tumor growth, and the hypoxia-inducible factors (HIF) 1 alpha and HIF-2 alpha are key transcription regulators of phenotypic adaptation to low oxygen levels. Moreover, mouse gene disruption studies have implicated HIF-2 alpha in embryonic regulation of tyrosine hydroxylase, a hallmark gene of the sympathetic nervous system. Neuroblastoma
Background Oral contraceptives were introduced almost 50 years ago, and over 100 million women currently use them. Oral contraceptives can reduce the risk of ovarian cancer, but the eventual public-health effects of this reduction will depend on how long the protection lasts after use ceases. We aimed to assess these effects. Methods Individual data for 23 257 women with ovarian cancer (cases) a
The uptake and killing of bacteria by human neutrophils are dependent on the fusion of secretory granules with forming phagosomes. The earliest component of exocytosis was found to precede phagosome closure, so that granular membrane constituents were detectable on the plasmalemma. We show that during phagocytosis of IgG-opsonized particles, this early secretory response is highly polarized in the
The aim of this master’s thesis is to examine how fiction authors seek information in their writing, which still is a vastly under-researched subject within Library and Information Science. Why then are there so few of us in this discipline who ask themselves which information behaviour and information needs that exist among the ones writing the literature filling our libraries? This study was car
Kombinationen av teknik, ekonomi och management inom teknikföretagsvärlden fick Nina Åxman att välja Industriell ekonomi på LTH. Efter flera år utomlands arbetar hon idag som vice president för global operations på Sandvik Rock Tools och har utnämnts till Framtidens kvinnliga ledare år 2020.
1 Bertil Molde Översättarens ansvar för språket Ur Språkvård 1979:4, något nedkortad Vårt språk, det språk som vi har som moders- mål och som vi var och en av oss lever med större delen av vårt liv, det är självklart vars och ens egendom att vårda och förvalta. Men det är också något som ägs av alla andra som har samma språk som medel för tankar och känslor, för tal och skrift. Vi använder ordet s
https://www.sol.lu.se/fileadmin/_migrated/content_uploads/Molde1979.pdf - 2026-07-20
Doctoral Thesis Structural Mechanics Report TV SM -1033 JEN S M A LM BO RG V IBRA TIO N S FRO M RA ILW A Y TRA FFIC - Com putational M odeling and A nalysis JENS MALMBORG VIBRATIONS FROM RAILWAY TRAFFIC Computational Modeling and Analysis DEPARTMENT OF CONSTRUCTION SCIENCES DIVISION OF STRUCTURAL MECHANICS Copyright © Jens Malmborg 2022. Printed by V-husets tryckeri LTH, Lund, Sweden, September 20
https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm1000/web1033.pdf - 2026-07-21
ALL students of the department – Sida 4 – STUDIEVÄGLEDARBLOGGEN Hoppa till huvudinnehåll Hem Studievägledaren vid Institutionen för arkeologi och antikens historia i Lund Lära sig vara student Sök Sök Stäng Meny Meny STUDIEVÄGLEDARBLOGGEN Blandad information för studenter på Institutionen för arkeologi och antikens historia vid Lunds universitet Arkiv för kategorin ALL students of the department S
https://arkstudier.blogg.lu.se/category/students-of-the-department/page/4/ - 2026-07-21
