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Label-free LC-MS methods are attractive for high-throughput quantitative proteomics, as the sample processing is straightforward and can be scaled to a large number of samples. Label-free methods therefore facilitate biomarker discovery in studies involving dozens of clinical samples. However, despite the increased popularity of label-free workflows, there is a hesitance in the research community

Smad5 is known to transduce intracellular signals from bone morphogenetic proteins (BMPs), which belong to the transforming growth factor-beta (TGF-beta) superfamily and are involved in the regulation of hematopoiesis. Recent findings suggest that BMP4 stimulates proliferation of human primitive hematopoietic progenitors in vitro, while early progenitors from mice deficient in Smad5 display increa

Revised simulation theory (Goldman, 2006) allows mental state attributions containing some or all of the attributor’s genuine, non-simulated mental states. It is thought that this gives the revised theory an empirical advantage, because unlike theory theory and rationality theory, it can explain egocentric bias (the tendency to over attribute ones’ own mental states to others). I challenge this vi

In a Northern country such as Sweden, energy use in the home may be reduced by 20% through changes in behaviour. However, little is known about how households respond to policy instruments encouraging such change or to what degree this in turn may affect the workload of women and men in such communities. The current study presents findings from interviews with 30 households in Sweden that particip

With growing concern over organised crime in Sweden, increased attention has been directed towards children's involvement in escalating violence. Children are portrayed both as victims of coercion and as voluntary participants, reflecting a dual approach in governmental policy. This study investigates how the issue of children's involvement in criminal activities is problematised in three

Since the economic reforms in 1978 the Chinese economy has shown remarkable growth rates. The countries in East Asia all had very high growth rates before they were hit by the economic crisis in 1997. Could the same thing happen to China? The aim of the thesis is to investigate if China is heading for an economic crisis. Based on theories and empirical studies of other economic crises we study the

Granule neurons of the dentate gyrus (DG) of the hippocampus undergo continuous renewal throughout life. Among cell cycle regulators, cyclin-dependent kinase 2 (Cdk2) is considered as a major regulator of S-phase entry. We used Cdk2-deficient mice to decipher the requirement of Cdk2 for the generation of new neurons in the adult hippocampus. The quantification of cell cycle markers first revealed

Due to social and environmental crises, the concept of sustainability has grown in importance in our society over the past years. Things are changing, even in the financial industry. From the perspective of investors, the general public, and enterprises, Corporate Social Responsibility and the creation of sustainable value are becoming more and more significant. One of the most cutting-edge tools

The aggregating proteoglycans (aggrecan, versican, neurocan, and brevican) are important components of many extracellular matrices. Their N-terminal globular domain binds to hyaluronan, but the function of their C-terminal region containing a C-type lectin domain is less clear. We now report that a 90-kDa protein copurifies with recombinant lectin domains from aggrecan and versican, but not from t

Local commercial fishing is often claimed to attract tourists to coastal communities. We investigate the impact of local fishing on tourism demand, measured as overnight stays, in Sweden. Using municipal-level data for the period 1998–2015, we perform a quantitative analysis using ordinary least squares (OLS) as well as panel-data methods that take unobserved heterogeneity between municipalities i

The apparition of adaptive immunity in Gnathostomata correlates with the expansion of the E-protein family to encompass E2-2, HEB, and E2A. Within the family, E2-2 and HEB are more closely evolutionarily related but their concerted action in hematopoiesis remains to be explored. Here we show that the combined disruption of E2-2 and HEB results in failure to express the early lymphoid program in Co

The Nordic countries have often been seen as “fore-runners” of energy efficiency in buildings in terms of both 1) the implementation of policy instruments and 2) the evaluation of actual effects. Since the 1970s, the Nordic countries have introduced a range of policy instruments for energy conservation in buildings. Interestingly, there are contrasting policy “styles” and experiences across the No

The practice of using quantitative risk assessments (QRAs) for managing risks in land-use planning varies between countries. Some regulatory regimes are highly prescriptive in terms of explicit requirements on methodology, assumptions, modelling tools, input data, risk criteria, etc. Others require risk analyses to support decision-making without regulating the details. The present study seeks to