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Neutrophil:lymphocyte ratio and cell-free DNA dynamics during excessive heat stress in occupational and experimental settings

Introduction Systemic inflammation is postulated to mediate heat stroke and heat-related organ injury, yet acute inflammatory responses among heat-stressed workers remains poorly understood. We aimed to describe neutrophil mobilisation and potential release of DNA during heat stress in multiple hot occupational settings and a controlled experimental setting. Methods Neutrophil:lymphocyte ratio (NL

Preload time-dependent effects of Panax ginseng on postprandial glucose tolerance. A randomized controlled study in healthy middle-aged participants

Objectives: Panax ginseng (P. ginseng, C.A. Meyer) is suggested to improve blood glucose regulation, but evidence remains inconsistent. We examined whether consuming P. ginseng as a preload before a carbohydrate-rich meal modulates postprandial glucose and insulin responses. Methods: In a randomized, double-blind, crossover trial, 22 healthy middle-aged adults consumed P. ginseng tablets containin

Estimation of Plasma Meropenem Concentrations in Patients with Severe Infections Using Ultraviolet and Visible Range Spectrophotometry : A Pilot Study

BACKGROUND AND OBJECTIVE: Achieving adequate concentrations of beta-lactam antibiotics in patients with severe infections is challenging, and therefore therapeutic drug monitoring (TDM) would be optimal for guiding beta-lactam dosing, but is often limited by availability. UV/VIS spectrophotometry can quantify drug levels in saline, and if those levels truly reflect plasma concentrations, it could

Single stab injuries to the trunk in assault cases-A comparative study of female and male victims in clinical forensic medicine

BACKGROUND/AIM: Determining the causation of an injury in living individuals is a key task for forensic pathologists. However, little is known about sex-based differences in injury characteristics. The study aims to examine sex-based differences in single stab injuries to the trunk among assault survivors, to potentially identify injury patterns that could aid forensic assessment and help in the m

Recent HIV infection among women and men enrolling to care in urban clinics in Ethiopia

BACKGROUND: Early HIV diagnosis allows timely interventions to control HIV transmission. We have determined the proportion of recent infections among people living with HIV (PLHIV) enrolling to care in Ethiopia and identified factors associated with recent infection. METHODS: Participants (aged ≥ 15 years) newly enrolled in HIV care were recruited from urban clinics in central Ethiopia (2022-2024)

Labor Productivity Convergence Dynamics within the Euro Zone: A Theoretical and Empirical Examination

Twelve years ago, eleven European countries voluntarily abandoned their home currencies and joined the Euro. The founding fathers of the Euro believed that creation of the common currency would strengthen integration among the members and catalyze economic convergence progress within the common currency area. This study examines this issue in detail. I focus on labor productivity convergence and s

The Gaia reference frame for bright sources examined using VLBI observations of radio stars

Context. Positions and proper motions of Gaia sources are expressed in a reference frame that ideally should be non-rotating relative to distant extragalactic objects, coincident with the International Celestial Reference System (ICRS), and consistent across all magnitudes. For sources fainter than 16th magnitude, this is achieved through Gaia's direct observations of quasars. At brighter magnitud

Including indigestible carbohydrates in the evening meal of healthy subjects improves glucose tolerance, lowers inflammatory markers, and increases satiety after a subsequent standardized breakfast.

Low-glycemic index (GI) foods and foods rich in whole grain are associated with reduced risk of type 2 diabetes and cardiovascular disease. We studied the effect of cereal-based bread evening meals (50 g available starch), varying in GI and content of indigestible carbohydrates, on glucose tolerance and related variables after a subsequent standardized breakfast in healthy subjects (n = 15). At br

Sapes pi publication list

Publikationer av SAPES PIs 2010-2012 Andersson, G. K. S., Rundlöf, M., and Smith, H. G. 2012 Organic Farming Improves Pollination Success in Strawberries. Plos One 7. Andersson, G. K. S., Rundlöf, M., and Smith, H. G. 2010 Time lags in biodiversity response to farming practices. Aspects of Applied Biology 100, 381-384. Bejai, S., Fridborg, I., and Ekbom, B. 2012 Varied response of Spodoptera litto

https://www.cec.lu.se/sites/cec.lu.se/files/sapes_pi_publication_list.pdf - 2026-05-30

Sorbitol and myo-inositol levels and morphology of sural nerve in relation to peripheral nerve function and clinical neuropathy in men with diabetic, impaired, and normal glucose tolerance

Aims: Sorbitol and myo-inositol levels and morphology of sural nerve were compared with nerve function and clinical neuropathy in men with diabetic, impaired (IGT), and normal glucose tolerance. Methods: After neurography of sural nerve and determinations of sensory thresholds for vibration, warm and cold on the foot, whole nerve sural nerve biopsy was performed in 10 men with Type 1 diabetes mell

Vanilloid receptors on capsaicin-sensitive sensory nerves mediate relaxation to methanandamide in the rat isolated mesenteric arterial bed and small mesenteric arteries

1. In the present study, the vasodilator actions of methanandamide and capsaicin in the rat isolated mesenteric arterial bed and small mesenteric arterial segments were investigated. 2. Methanandamide elicited concentration-dependent relaxations of preconstricted mesenteric arterial beds (pEC 50 = 6.0 ± 0.1, E(max) = 87 ± 3%) and arterial segments (pEC 50 = 6.4 ± 0.1, E(max) = 93 ± 3%). 3. In art

Time between anterior cruciate ligament injury and reconstruction and cartilage metabolism six-months following reconstruction

Background: To determine the association between time from injury to ACL reconstruction (TimeInjury-ACLR) and biochemical markers of cartilage metabolism and inflammation six months following ACL reconstruction (ACLR). Methods: Individuals with a unilateral ACL injury were enrolled at initial presentation in the orthopedic clinic; blood was collected six months following ACLR. Enzyme-linked immuno

Sevoflurane provides better haemodynamic stability than propofol during right ventricular ischaemia-reperfusion

OBJECTIVES: To assess whether sevoflurane provides better haemodynamic stability than propofol in acute right ventricular (RV) ischaemia-reperfusion. METHODS: Open-chest pigs (mean ± standard deviation, 68.8 ± 4.2 kg) anaesthetized with sevoflurane (n = 6) or propofol (n = 6) underwent 60 min of RV free wall ischaemia and 150 min of reperfusion. Haemodynamic parameters and blood flow in the 3 majo

Everolimus Initiation With Early Calcineurin Inhibitor Withdrawal in De Novo Heart Transplant Recipients : Long-term Follow-up From the Randomized SCHEDULE Study

BACKGROUND: A calcineurin inhibitor (CNI)-free immunosuppressive regimen has been demonstrated to improve renal function early after heart transplantation, but long-term outcome of such a strategy has not been well described. METHODS: In the randomized SCHEDULE trial, de novo heart transplant recipients received (1) everolimus with reduced-exposure CNI (cyclosporine) followed by CNI withdrawal at

Dietary Glycemic Index and Load and the Risk of Type 2 Diabetes : A Systematic Review and Updated Meta-Analyses of Prospective Cohort Studies

Published meta-analyses indicate significant but inconsistent incident type-2 diabetes(T2D)-dietary glycemic index (GI) and glycemic load (GL) risk ratios or risk relations (RR). It is nowover a decade ago that a published meta-analysis used a predefined standard to identify validstudies. Considering valid studies only, and using random effects dose-response meta-analysis(DRM) while withdrawing sp

Genome-wide association meta-analysis of functional outcome after ischemic stroke

OBJECTIVE: To discover common genetic variants associated with poststroke outcomes using a genome-wide association (GWA) study. METHODS: The study comprised 6,165 patients with ischemic stroke from 12 studies in Europe, the United States, and Australia included in the GISCOME (Genetics of Ischaemic Stroke Functional Outcome) network. The primary outcome was modified Rankin Scale score after 60 to

Sedimentation of Nodularia spumigena and distribution of nodularin in the food web during transport of a cyanobacterial bloom from the Baltic Sea to the Kattegat

Nodularia spumigena is a toxic cyanobacteria that blooms in the Baltic Sea every year. In the brackish water of the Baltic Sea, its toxin, nodularin, mainly affects the biota in the surface water due to the natural buoyancy of this species. However, the fate of the toxin is unknown, once the cyanobacteria bloom enters the more saline waters of the Kattegat. In order to investigate this knowledge g

Renal function after out-of-hospital cardiac arrest; The influence of temperature management and coronary angiography, a post hoc study of the target temperature management trial

Background: To elucidate the incidence of acute kidney injury (AKI) after out-of-hospital cardiac arrest (OHCA) and to examine the impact of target temperature management (TTM) and early coronary angiography on renal function. Methods: Post hoc analysis of the TTM trial, a multinational randomised controlled trial comparing target temperature of 33 °C versus 36 °C in patients with return of sponta

Detection of circulating tumor cells and circulating tumor DNA before and after mammographic breast compression in a cohort of breast cancer patients scheduled for neoadjuvant treatment

PurposeIt is not known if mammographic breast compression of a primary tumor causes shedding of tumor cells into the circulatory system. Little is known about how the detection of circulating biomarkers such as circulating tumor cells (CTCs) or circulating tumor DNA (ctDNA) is affected by breast compression intervention.MethodsCTCs and ctDNA were analyzed in blood samples collected before and afte