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Enhancers are short DNA segments (50–1500 bp) that effectively activate gene transcription when transcription factors (TFs) are present. There is a correlation between the genetic differences in enhancers and numerous human disorders including cancer and inflammatory bowel disease. In computational biology, the accurate categorization of enhancers can yield important information for drug discovery
This study aims to develop a theoretical and analytical approach for studying discretion, automated decision-making (ADM) and the consequential public values. This is achieved through our proposed approach, an overview of literature and an empirical test. The context of our empirical test is decisions made about economic support in social work. The research questions are as follows: 1) What are th
Objective. Development of ascites in patients with liver cirrhosis is an ominous sign with a poor outcome. A liver transplantation must be considered, and it then becomes important to know if there are any factors indicating a worsened prognosis. Material and methods. We used official registers for a follow-up study of at least 5 years considering the prognosis of 155 prospectively recruited in-pa
Title: What Effects Do Realised Share Repurchases Have on Share Liquidity? Seminar date: 14th of January 2021. Course: FEKH89, Degree Project Undergraduate level, Business Administration - Corporate Finance. 15 ECTS. Authors: Maximilian Holmberg, Amanda Melin, and Marcus von Schéele. Supervisor: Göran Anderson. Key words: Share liquidity, share repurchases, Russell 3000 Index, U.S Stock market
Strategic alignment has been identified as the overarching philosophy that aligns Business Process Management (BPM) to organisational strategy, but often a gap appears between organisational strategy and operational issues. Willingness and ability to contribute to BPM have been identified as two major operational issues when achieving strategic alignment of BPM. Hence, this thesis aims to close th
Medier och sport är nära relaterade och påverkar varandra. Den utveckling som sker på mediefronten i Sverige idag, inom framförallt digital-TV borde då även påverka den allsvenska fotbollen. Om den då gör det, hur gör den det och vad kan det ge för konsekvenser? Syftet med uppsatsen är att ge en bild av hur förhållandet ser ut idag mellan TV och allsvensk fotboll samt vad som kan tänkas hända i fr
Popular Abstract in Swedish Magnetisk resonanstomografi: Patienters upplevelser och betydelsen av anpassad information och förberedelse för vuxna och barn. Magnetisk resonanstomografi (MRT) har sedan tidigt 1980-tal ökat i betydelse och är idag en vanlig undersökning för både vuxna och barn. Undersökningen innebär att patienten ligger i en smal tunnel i magnetkameran och när bilderna tas hörs kraMagnetic resonance imaging (MRI) is becoming an increasingly common form of exami¬nation for both adults and children. Although it is non-invasive and considered painless, both adults and children experience anxiety during the examination. The technique is sensitive to motion and for that reason many children are anaesthetised. The aim of this thesis was to improve patient care through exploring a
This cross-sectional case study investigates patterns of politicisation in election campaigns of the German Eurosceptic party Alternative für Deutschland (AfD) by means of a comparative multi-level analysis. It adds to the existing literature by examining the Eurosceptic elements of the party’s campaign communication across various decision-making levels. It examines EU issue salience, the dimensi
Change towards a sustainable company is driven either by media or the company, the argument goes. It is though questionable, if companies as individual actors have an impact on the environment at all, or if they are too small in the global economy. Using the macro- economic gravity model, the size question can be answered positively, the companies do have an impact. Thus reasons why companies chan
This is a study of the promotion of democracy and governance as a part of Japan’s official development cooperation. Despite being one of few Asian democracies among aid donors, Japan’s work with democracy and governance has largely been overlooked in the discussion of its aid programme. This research seeks to expand on the current literature by examining what factors and driving forces interact to
The coronavirus disease-2019 (COVID-19) pandemic has had an unprecedented impact leading to novel adaptations in post-graduate medical education for cardiovascular and general internal medicine. Whilst the results of initial community COVID-19 vaccination are awaited, continuation of multimodality teaching and training that incorporates telelearning will have enduring benefit to post-graduate educ
Background: While cognitive-behavioral therapy (CBT) is the gold-standard psychological treatment for major depression (MD), non-response and lacking stability of treatment gains are persistent issues. Potential factors influencing treatment outcome might be lifetime trauma history and possibly associated primarily prefrontal-cortex- and hippocampus-dependent cognitive alterations. Method: We inve
District heating and cooling is a simple but powerful technology that could contribute to decarbonising Europe's heating and cooling supply. However, its current overall penetration is minor. Furthermore, future systems could adopt different configurations with various settings of temperature levels or production location. This thesis has aimed to improve existing tools to evaluate district heatin
This paper presents a joint model of multivariate longitudinal data and multistate data with application to modeling and predicting autoantibody development in The Environmental Determinants of Diabetes in the Young (TEDDY) study. The model quantifies the risks of state transitions based on observed time-varying and non-time-varying risk factors. Based on the estimated model, a dynamic prediction
The CRISPR/Cas9 system is a versatile tool for functional genomics and forward genetic screens in mammalian cells. However, it has been challenging to deliver the CRISPR components to sensitive cell types, such as primary human hematopoietic stem and progenitor cells (HSPCs), partly due to lentiviral transduction of Cas9 being extremely inefficient in these cells. Here, to overcome these hurdles,
