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This study aimed to obtain high-resolution 3D isotropic turbo spin-echo (TSE) wrist MRI acquisitions at 7T, with and without fat suppression, facilitated by compressed-sensing (CS) acceleration. In 16 healthy subjects, fat-suppressed (FS) and nonfat-suppressed (NFS) TSE wrist images were obtained. The protocol consisted of a SENSE-accelerated scan, with an isotropic voxel size of 0.45 mm and acqui
BACKGROUND: Platelet transfusions are frequent in the Intensive Care Unit (ICU), either as prophylaxis against bleeding complications or as treatment for bleeding. The European Society of Intensive Care Medicine guidelines for ICU patients generally recommend not using prophylactic platelet transfusions unless the platelet count falls below 10 × 10 9 cells/L in non-bleeding patients and make no re
Background: Guidance on managing acute mesenteric ischaemia (AMI) is largely based on expert opinion and retrospective studies pooling different subtypes of AMI. In clinical practice, management strategy is often selected based on the patient’s severity of illness, whereas randomized controlled trials or even adjusted analyses comparing different strategies are rarely available. We aimed to perfor
Background: Ultrafiltration (UF) insufficiency in peritoneal dialysis (PD) often leads to transfer to hemodialysis. Therefore, strategies to prolong time on therapy are needed. The use of a combined crystalloid and colloid solution, also called bimodal PD, can help improve UF. Methods: We propose a method for reconstituting bimodal solutions. Three bimodal PD solutions, with respectively 100 ml (s
Purpose: The purpose of this work was to evaluate the visibility of simulated lesions in 2D digital mammography (DM) and breast tomosynthesis (BT) images of patients. Methods: Images of the same women were acquired on both a DM system (Mammomat Novation, Siemens Healthcare, Erlangen, Germany) and a BT prototype system adapted from the same type of DM system. Using the geometrical properties of the
OBJECTIVES: To clarify whether the intensity of exposure to organic acid anhydrides (OAAs) is associated with the risk of sensitisation to these allergens. METHODS: The investigations were carried out in three different manufacturing plants (A, B, and C) where OAAs were used in the production of epoxy resins. Methyltetrahydrophthalic acid anhydride (MTHPA) was used in all three plants. The exposur
We present the red-listed plants and fungi that have been found in the central parts of the parish of Stenbrohult, southern Sweden. In the middle of the study areas Carl Linnaeus was born in 1707, and he spent his summers there until 1727. Of the 11 currently red-listed vascular plants (Gärdenfors 2000) that have been recorded since 1970 all occurred there also 300 years ago. Mosses, lichens and f
Purpose: To examine whether panretinal photocoagulation for severe non-proliferative retinopathy in type 1 diabetes patients could halt the progression of retinopathy with subsequent vitreous haemorrhages and visual impairment. Methods: During a 10-year follow-up study period of 344 type 1 diabetes patients, 81 subjects went through panretinal photocoagulation. Forty patients were treated for sev
BACKGROUND AND PURPOSE: To determine how a recently proposed clinical stroke subclassification corresponds to specific findings on computed tomography (CT) and magnetic resonance imaging (MRI) of the brain. METHODS: Two hundred twenty-eight patients with first-ever stroke were divided into four clinical subgroups: (1) total anterior circulation syndrome: both cortical and subcortical symptoms from
Popular Abstract in Swedish Variabilitet i ett läkemedels farmakokinetiska (hur ett läkemedel omsätts i kroppen) och farmakodynamiska (vilken effekt ett läkemedel har) egenskaper kan resultera i att olika individer som erhållit samma dos av ett läkemedel får olika effekter av läkemedel. Biverkningar eller utebliven effekt kan innebära allvarliga konsekvenser för den enskilda individen. VariabiliteVariability in pharmacokinetic and pharmacodynamic parameters between individuals can be due to intrinsic and extrinsic factors. In this thesis three different areas regarding sources of variability have been investigated. 1. Formulation properties as an extrinsic source of variability. Lipophilic substances often have poor oral bioavailability and high inter- and intraindividual variability. High
OBJECTIVE: To identify perinatal factors associated with cerebral palsy (CP). METHODS: This was a case-control study based on the Swedish Medical Birth Registry and the Swedish Hospital Discharge Registry, including 2,303 infants born in Sweden 1984-1998 with a diagnosis of CP and 1.6 million infants without this diagnosis. Odds ratios (ORs) with 95% confidence intervals (Cis) were calculated. RES
OBJECTIVE—To examine the effects of dipeptidyl peptidase-IV (DPP-4) inhibition on meal-related β-cell function and insulin sensitivity over 52 weeks in type 2 diabetes. RESEARCH DESIGN AND METHODS—In a 12-week core study, placebo (n = 51) or vildagliptin (n = 56; 50 mg OD) was added to metformin treatment (1.5–3.0 mg/day). A 40-week extension followed in 71 patients. Meal tests were performed at
Objectives To describe the endosonographic image of the anal sphincter 2-7 days after delivery in women who had undergone a primary repair of an obstetric sphincter tear. Methods Forty-eight women who had suffered a third- or fourth-degree sphincter tear at delivery and had undergone primary sphincter repair were examined with endoanal sonography 2-7 days after delivery. A score from 0 to 16 was
Leptin is a key biological marker related to energy balance and development of diabetes and cardiovascular diseases. Its levels are increased in populations with a high degree of the metabolic syndrome. Life history of evolution has, however, largely taken place under the ecological context of hunting and gathering. In this study, we explored whether the first steps of transition to sedentary agri
X-ray diffraction methods have been used to study the crystal structure of different compounds, both organic and inorganic. The inorganic compounds were all synthesized by solid state reactions. A new compound, Re4As6S3, was synthesized and its structure was solved by Rietveld methods. Re4As6S3 is a cluster compound described by a
Popular Abstract in Swedish All materia består av atomer. Avhandlingen du just nu läser är uppbyggd av atomer; till och med du själv är uppbyggd av atomer. En kemist är intresserad av vilka atomer som hänger ihop för att bilda molekyler och hur dessa molekyler kan sammanfogas till fasta material. Man kan likna det vid att molekylerna är en byggsten som då de sammanfogas bildar en byggnadskonstruktHow do molecules arrange themselves in a crystal? It is today not possible to definite predict the three-dimensional packing arrangement of molecules in the crystalline solid state. The aim of the work presented in this thesis has been to gain more knowledge of what principles that govern molecular packing. Platinum(II) complexes have been chosen as model system since these compounds are stable,
The enzymatic interesterification of a solvent-free, equimolar mixture of trilaurin and 1,3-palmitin-2-olein was studied using three immobilized lipase preparations as catalysts. Analysis of triacylglycerol (TAG) content and fatty acid (FA) distribution monitored the lipase-catalyzed interesterification in sn-1,3 positions and FA exchange in the sn-2 position caused by acyl migration. Lipase from
BACKGROUND: Deficits in emotional processing can be detected in the pre-manifest stage of Huntington's disease and negative emotion recognition has been identified as a predictor of clinical diagnosis. The underlying neuropathological correlates of such deficits are typically established using correlative structural MRI studies. This approach does not take into consideration the impact of disrupti
PURPOSE: The aim of this study was to describe long-term adjustment to life with an ileal pouch-anal anastomosis after surgery for ulcerative colitis, to investigate the relationship of pouch function to adjustment, and to explore factors affecting quality of life.METHODS: A total of 369 patients treated between 1982 and 1993 were included in the study. Questionnaires designed to assess bowel (pou
