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MOTIVATION: Gene expression-based multiclass prediction, such as tumor subtyping, is a non-trivial bioinformatic problem. Most classifier methods operate by comparing expression levels relative to other samples. Methods that base predictions on the expression pattern within a sample have been proposed as an alternative. As these methods are invariant to the cohort composition and can be applied to
Research have shown that the correct integration of daylight and electric lighting reduces the energy use in buildings, while improving visual comfort. Smart shading systems, especially those electrically controlled, play an important role to control solar radiation. Similarly, smart and dimmable/tunable lighting can help to adjust the artificial light to the real users' needs. This paper presents
Using a new sample environment, the two operando surface diagnostic techniques two-dimensional surface optical reflection (2D-SOR) and polarization-modulated infrared reflection–absorption spectroscopy (PM-IRRAS) have been combined with mass spectrometry (MS) to characterize a catalytic reaction. With both techniques integrated in a custom-built setup, we can correlate molecular information of the
The production of biopharmaceuticals so far has been based on batch processes that are robust and well-known, but very inefficient and inflexible, causing the products to be very expensive and process development to be slow and costly. The production of biopharmaceuticals is thus changing towards integrated continuous biomanufacturing (ICB) in order to reduce costs and increase flexibility in a co
We report on an optical investigation of the pyrolysis and photolysis of trimethylindium (TMIn) as a typical metalorganic precursor for functional nanowire growth, aiming at an in-depth understanding of the governing chemistry and optimization of aerosol-based (aerotaxy) and epitaxial growth processes. A flow reactor with special consideration given to optical access was built to provide the chemi
The Pythia event generator is used in several contexts to study hadron and lepton interactions, notably p p and p p ¯ collisions. In this article we extend the hadronic modelling to encompass the collision of a wide range of hadrons h with either a proton or a neutron, or with a simplified model of nuclear matter. To this end we model hp total and partial cross sections as a function of energy, an
A Soft X-ray free electron laser (FEL) for the MAX IV Laboratory is currently in the design phase and it will use the existing 3 GeV linac. Present stability limits in the RF and the photocathode laser will affect the performance of the FEL. One of the critical elements for the design of a FEL is to have an estimation on jitter effects of the accelerator parameters on the X-ray radiation. In this
Small- and medium-sized enterprises (SMEs) have inherent characteristics, which require specific solutions for improving the sustainability performance of their operations. The purpose of this paper is to increase the knowledge on barriers and enablers for the adoption of sustainable manufacturing by manufacturing SMEs and to provide insights into what enablers can be used to overcome existing bar
The alliance between the seemingly disparate Lebanese Christian party Free Patriotic Movement and the Shi’a organization Hezbollah has survived many local and regional upheavals since the signing of the memorandum of understanding (MoU) in February 2006. The pact was strengthened after the 2006 summer war and has stood for 15 years - despite political assassinations and low-intensity conflict in L
Although it is advocated that end-users are engaged in developing evidence-based injury prevention training to enhance the implementation, this rarely happens. The ‘Implementing injury Prevention training ROutines in TEams and Clubs in youth Team handball (I-PROTECT)’ uses an ecological participatory design incorporating the perspectives of multiple stakeholders throughout the project. Within the
For polarization-resolved reflection experiments such as ellipsometry, not only is high reflectivity in a wide spectral range required for mirrors but also the quality of their polarization response is important. Furthermore, for VUV ellipsometry, optimal angles of incidence at the sample are between 45° and 60° with respect to the surface normal. In the best case, a setup should even allow variab
BACKGROUND: Plasma biomarkers for Alzheimer's disease (AD) have broad potential as screening tools in primary care and disease-modifying trials. Detecting elevated amyloid-β (Aβ) pathology to support trial recruitment or initiating Aβ-targeting treatments would be of critical value. In this study, we aimed to examine the robustness of plasma biomarkers to detect elevated Aβ pathology at different
We prove Nehari s theorem for integral Hankel and Toeplitz operators on simple convex polytopes in several variables. A special case of the theorem, generalizing the boundedness criterion of the Hankel and Toeplitz operators on the Paley Wiener space, reads as follows. Let = (0, 1)d be a d-dimensional cube, and for a distribution f on 2, consider the Hankel operator f (g)(x) = λ f (x + y)g(y) dy,
We describe the outcome of a data challenge conducted as part of the Dark Machines (https://www.darkmachines.org) initiative and the Les Houches 2019 workshop on Physics at TeV colliders. The challenged aims to detect signals of new physics at the Large Hadron Collider (LHC) using unsupervised machine learning algorithms. First, we propose how an anomaly score could be implemented to define model-
This paper presents the hardware/software generation backend of a code generation framework. The backend aims at synthesizing complete systems based on RISC-V cores with accelerators from a single-language description. The framework takes the dataflow description of an algorithm as input and generates a combination of hardware (in Chisel) and software (in C) that interacts with the hardware. The h
Studies on animal colour vision typically focus on the chromatic aspect of colour, which is related to the spectral distribution, and disregard the achromatic aspect, which is related to the intensity (“brightness”) of a stimulus. Although the chromatic component of vision is often most reliable for object recognition because it is fairly context independent, the achromatic component may provide a
Current local or regional flood risk assessments, as required by the EU flood risk directive, rarely account for cascading effects due to interdependencies between critical infrastructures. However, it is essential to consider these effects, as they may severely impact areas outside the immediate flood risk area. The main purpose is to present and problematize a method (AB-CEM) for mapping and ana
