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Background. Epidemiological studies indicate that physical activity reduces the risk of cancer. Physical inactivity or sedentary behavior, has recently been suggested as a risk factor independent of physical activity level. Breast and endometrial cancer incidence have both been associated with physical activity, and endometrial cancer incidence with physical inactivity/sedentary behavior. The purp
Objective Neighbourhood deprivation is a recognised predictor of coronary heart disease (CHD). The overall aim was to investigate if accumulated exposure to neighbourhood deprivation resulted in higher odds of CHD. Design This is a longitudinal cohort study. Models based on repeated assessments of neighbourhood deprivation as well as single-point-in-time assessments were compared. Setting Sweden.
BACKGROUND: To inform future preventive measures including repeated vaccinations, we have searched for a clinically useful immune correlate of protection against fatal COVID-19 among nursing homes residents.METHODS: We performed repeated capillary blood sampling with analysis of S-binding IgG in an open cohort of nursing home residents in Sweden. We analyzed immunological and registry data from 16
BACKGROUND: Contact allergy rates of linalool and limonene hydroperoxides (HPs) have increased.OBJECTIVES: To demonstrate the patterns of simultaneous positive patch test (PT) reactions and prevalences of multiple contact allergies (MCAs) in patients with contact allergy to linalool and/or limonene HPs.METHODS: A retrospective analysis of consecutive dermatitis patients in 2015-2020 was performed.
Expansions of innovation policies have been paralleled with an increase in the evaluations of such policies. Yet, there are few systematic evaluations of how such evaluations are conducted, by whom, and their overall conclusions. We analyze 110 evaluations of innovation policy in Sweden from 2005 to 2019. Our findings show that the majority of these evaluations are positive, about one-third are neExpansions of innovation policies have been paralleled with an increasein the evaluations of such policies. Yet, there are few systematic evaluations of how such evaluations are conducted, by whom, and their overall conclusions. We analyze 110 evaluations of innovation policy in Sweden from 2005 to 2019. Our findings show that the majority of these evaluations are positive, about one-third are neu
Now extinct, the aurochs (Bos primigenius) was a keystone species in prehistoric Eurasian and North African ecosystems, and the progenitor of cattle (Bos taurus), domesticates that have provided people with food and labour for millennia1. Here we analysed 38 ancient genomes and found 4 distinct population ancestries in the aurochs—European, Southwest Asian, North Asian and South Asian—each of whic
BACKGROUND: Polycystic ovary syndrome (PCOS) has previously been associated with several comorbidities that may have shared genetic, epigenetic, developmental or environmental origins. PCOS may be influenced by prenatal androgen excess, poor intrauterine or childhood environmental factors, childhood obesity and learned health risk behaviors. We analyzed the association between PCOS and several rel
Mexico has experienced the dramatic escalation of crime and violence in an organized form since the 1990s, and have also witnessed the highest number of homicides in the last ten years. It has adversely affected the national security, economic growth and social development with an especially detrimental effect on youth in Mexico. This study examines the direct and indirect impacts of drug trade-re
Behandling av personuppgifter, vilket undersöks i denna uppsats, sker i den offentliga och privata sektorn, och i organisationer av alla storlekar. Personuppgiftsbehandlingar förekommer i varje gren av en organisation och hos alla olika aktörer, inom så spridda områden som rättsväsendet eller en frisörsalong. Mer specifikt syftar denna uppsats till att studera definitionen av "behandling"Personal data processing, as will be examined in this thesis, occurs in the public and the private sectors, in organisations of every size. It occurs in every branch of an organisation and by all different actors, be it law-enforcement or a hairdresser saloon. More specifically this thesis aims to study the definition of ‘processing’ and attempts to highlight the features and characterisation of i
Type 2 diabetes is highly prevalent in immigrants to Sweden from Iraq, but the prevalence of cardiovascular disease (CVD) and its risk factors are not known. In this survey we aimed to compare the prevalence of CVD and CVD-associated risk factors between a population born in Iraq and individuals born in Sweden.
Germline mutations in the tumour suppressor gene CDKN2A occur in 5-20% of familial melanoma cases. A single founder mutation, p.Arg112dup, accounts for the majority of CDKN2A mutations in Swedish carriers. In a national program, carriers of p.Arg112dup mutation have been identified. The aim of this study was to assess cancer risks in p.Arg112dup carriers and their first degree relatives (FDRs) and
The public health impact of population-based mammography screening programs depends on high participation rates. Thus, monitoring participation rates, as well as understanding and considering the factors influencing attendance, is important. With the goal to acquire information on the appropriate level of intervention for increasing screening participation our study aimed to (1) examine whether, o
Background: We previously reported significant associations between genetic variants in insulin receptor substrate 1 (IRS1) and breast cancer risk in women carrying BRCA1 mutations. The objectives of this study were to investigate whether the IRS1 variants modified ovarian cancer risk and were associated with breast cancer risk in a larger cohort of BRCA1 and BRCA2 mutation carriers. Methods: IRS1
The aim of this present study was to examine duration of breastfeeding in relation to the risk of different subgroups of breast cancer. A prospective cohort, The Malmö Diet and Cancer study, including 14092 parous women, were followed during a mean of 10.2 years and a total of 424 incident breast cancers were diagnosed.
The insulin-like growth factor (IGF) pathway has been implicated as risk modifier in premenopausal breast cancer. In this study, associations between single nucleotide polymorphisms (SNPs) and diplotypes in the IGFBP1 and IGFBP3 genes and circulating IGFBP-3 levels, BRCA family status and breast cancer among women from high-risk breast cancer families were investigated. Nine IGFBP1 and IGFBP3 SNPs
En aktieägare i ett tillgångsägande aktiebolag, som vill få egenhändig kontroll över en tillgångs avkastningsförmåga, har idag två möjliga vägar att välja mellan för att uppnå sitt mål. Denne kan förvärva aktier i bolaget eller förvärva, direkt eller indirekt, själva tillgången. Beroende på vilken väg som väljs kommer aktieägaren stöta på olika typer av hinder. Denna uppsats syftar till att redogöA shareholder in an asset holding company, who wishes to gain direct control over the asset's capacity to produce profit, currently has two possible paths to choose from in order to achieve his or her goal. He or she can either acquire shares in the company or directly or indirectly acquire the asset itself. Depending on the chosen path, the shareholder will encounter different types of obstac
En aktieägare i ett tillgångsägande aktiebolag, som vill få egenhändig kontroll över en tillgångs avkastningsförmåga, har idag två möjliga vägar att välja mellan för att uppnå sitt mål. Denne kan förvärva aktier i bolaget eller förvärva, direkt eller indirekt, själva tillgången. Beroende på vilken väg som väljs kommer aktieägaren stöta på olika typer av hinder. Denna uppsats syftar till att redogöA shareholder in an asset holding company, who wishes to gain direct control over the asset's capacity to produce profit, currently has two possible paths to choose from in order to achieve his or her goal. He or she can either acquire shares in the company or directly or indirectly acquire the asset itself. Depending on the chosen path, the shareholder will encounter different types of obstac
BACKGROUND: Postmenopausal hormone therapy (HRT) and oral contraceptive (OC) use have in several studies been reported to be associated with a decreased colorectal cancer (CRC) risk. However, data on the association between HRT and OC and risk of different clinicopathological and molecular subsets of CRC are lacking. The aim of this molecular pathological epidemiology study was therefore to evalua
