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BACKGROUND: Gleason grading is the standard diagnostic method for prostate cancer and is essential for determining prognosis and treatment. The dearth of expert pathologists, the inter- and intraobserver variability, as well as the labour intensity of Gleason grading all necessitate the development of a user-friendly tool for robust standardisation.OBJECTIVE: To develop an artificial intelligence

Acute myeloid leukemia (AML) is associated with poor survival, and there is a strong need to identify disease vulnerabilities that might reveal new treatment opportunities. Here, we found that Toll-like receptor 1 (TLR1) and TLR2 are upregulated on primary AML CD34+CD38-cells relative to corresponding normal bone marrow cells. Activating the TLR1/TLR2 complex by the agonist Pam3CSK4 inMLL-AF9-driv

Lung cancer accounts for 1.6 million deaths per year worldwide. The majority of patients are diagnosed at advanced stages of the disease and often present with metastasis. Thus, the 5-year survival rate of lung cancer remains around 15%. Early diagnosis of lung cancer allows for better control of the disease with 5-year survival rates up to around 70%. Chest radiography is the most common techniqu

MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. There have been several reports of miRNA deregulation in prostate cancer and the biological evidence for an involvement of miRNAs in prostate tumorigenesis is increasing. In this study, we show that miR-34c is downregulated in prostate cancer (p = 0.0005) by performing qRT-PCR on 49 TURPs from prosta

Breast tumors from BRCA1 germ line mutation carriers typically exhibit features of the basal-like molecular subtype. However, the specific genes recurrently mutated as a consequence of BRCA1 dysfunction have not been fully elucidated. In this study, we utilized gene expression profiling to molecularly subtype 577 breast tumors, including 72 breast tumors from BRCA1/2 mutation carriers. Focusing on

Identification of determinants of fate choices in hematopoietic stem cells (HSCs) is essential to improve the clinical use of HSCs and to enhance our understanding of the biology of normal and malignant hematopoiesis. Here, we show that high-mobility group AT hook 2 (HMGA2), a nonhistone chromosomal-binding protein, is highly and preferentially expressed in HSCs and in the most immature progenitor

The response of childhood acute lymphoblastic leukemia (ALL) to dexamethasone predicts the long-term remission outcome. To explore the mechanisms of dexamethasone resistance in B cell ALL (B-ALL), we generated dexamethasone-resistant clones by prolonged treatment with dexamethasone. Using RNA-sequencing and high-throughput screening, we found that dexamethasone-resistant cells are dependent on rec

The fact that breast cancer patients with local or distal dissemination exhibit decreased survival, promotes a search for novel mechanisms to suppress such tumor progression. Here we have determined the expression of pro-inflammatory cysteinyl leukotriene receptors (CysLTRs) in breast tumor tissue and their signaling effect on breast cancer cell functions related to tumor progression. Patients wit

During development, hematopoietic stem cells (HSCs) undergo a rapid expansion in the fetal liver (FL) before settling in the adult bone marrow. We recently reported that proliferating adult HSCs are vulnerable to ER stress caused by accumulation of mis-folded proteins. Here, we find that FL-HSCs, despite an increased protein synthesis rate and a requirement for protein folding, do not upregulate E

The aim of this investigation was to assess the Ku70/Ku80 complex as a potential target for antibody imaging of prostate cancer. We evaluated the in vivo and ex vivo tumor targeting and biodistribution of the (111)In-labeled human internalizing antibody, INCA-X ((111)In-DTPA-INCA-X antibody), in NMRI-nude mice bearing human PC-3, PC-3M-Lu2 or DU145 xenografts. DTPA-conjugated, non-labeled antibody

Whereas the characterization of B lymphoid progenitors has been facilitated by the identification of lineage-and stage-specific surface markers, the continued identification of differentially expressed proteins increases our capacity to explore normal and malignant B cell development. To identify novel surface markers with stage-specific expression patterns, we explored the reactivity of CD19+ B c

In recent years a growing amount of research has been conducted in the area of workplace incivility. Whereas many studies have focused on the victims and the consequences of incivility, little attention has been paid to the perpetrators and antecedents of workplace incivility. This study aims to identify possible antecedents of workplace incivility, by investigating organizational aspects as well In recent years a growing amount of research has been conductedin the area of workplace incivility. Whereas many studies havefocused on the victims and the consequences of incivility, littleattention has been paid to the perpetrators and antecedents ofworkplace incivility. This study aims to identify possibleantecedents of workplace incivility, by investigating organizationalaspects as well as the

..;i,u KAROLINSKA UNIVERSITETSSJUKHUSET l ( l) Till vederbörande, Stöd för den Nationella 7T MR-anläggningens ansökan om bidrag till forskningsinfrastruktur av nationellt intresse, I min roll som Professor och forskargruppsledare inom Radiologi vid institutionen för Molekylär Medicin och Kirurgi vill jag med detta brev uttrycka mitt stöd för den ansökan rörande den Nationella 7T MR-anläggningen so

https://www.lbic.lu.se/sites/lbic.lu.se/files/2021-10/Behovsanm%C3%A4lan_Nationella_7T_MR_anl%C3%A4ggningen_St%C3%B6djebrev.pdf - 2026-05-20

LUNDS UNIVERSITET FORSKNING OCH INNOVATION Ny mEDICIN mOT bLODCANCER 5u mED STADEN SOm mILjöFöREbILD 6u LUNDENSISKA INNOVATIONER OCH UPPTÄCKTER 8 - 9u STORA FöRVÄNTNINGAR På KRAFTFULLT mIKROSKOP 10u 2 EN bREDARE SyN På INNOVATION LUNDS UNIVERSITET ÄR, med sina åtta fakulteter, en enorm kunskapsbank. Ett universitet präglat av mångfald är ett universitet med goda möjlighe- ter till innovation och n

https://www.lu.se/sites/www.lu.se/files/innovationsbroschyr_se_low_1.pdf - 2026-05-20

Sonestedt, PhD CV November 2016 Curriculum Vitae Emily Sonestedt Address: Clinical Research Centre, 60:13, Jan Waldenströms gata 35, SE-205 02 Malmö, Sweden E-mail: emily.sonestedt@med.lu.se Telephone: +46(0)40 39 13 25 Mobile: +46(0)737 00 71 45 ORCID ID: 0000-0002-0747-4562 EDUCATION 2009 PhD, public health. Title: Plant foods, plasma enterolactone and breast cancer – with a focus on estrogen re

https://www.ludc.lu.se/sites/ludc.lu.se/files/emily_sonestedt_cv_hemsidan_ludc_161031.pdf - 2026-05-20