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A set of nineteen C-galactopyranosyl ligands, which included constrained compounds based on a bicyclic trans-decalin type system. were synthesized via click chemistry from 2-(β-d-C-galactopyranosyl) ethylene azide intermediates. The compounds were evaluated for binding to various galectins and the most promising inhibitor from the series was a constrained 3-O-benzylated galactopyranose derivative,
INTRODUCTION: Health promotion in everyday settings is of great importance for both individual health and organizational sustainability. A settings-based approach emphasizes how social, physical, and organizational contexts shape the conditions for health. Central principles in health promotion are participation, empowerment, and person-centeredness, which emphasize the active role of the person o
Denna avhandling undersöker styrningen av koldioxidavskiljning och -lagring (CCS) i den nuvarande fasen av policydriven implementering inom europeisk klimatpolitik. Min forskning placeras i mellan etablerad kritik av CCS och dess framväxande, centrala roll i bindande nettonollstrategier. Jag intar en kritiskt pragmatisk hållning som erkänner att CCS är en omtvistad teknik som innebär risker för inThis thesis examines the governance of Carbon Capture and Storage (CCS) technology in its current phase of policy-driven deployment within European climate policy. Positioned in the gap between established critique of CCS and its newly central role in binding net-zero strategies, my research adopts a critical-pragmatic stance to acknowledge that CCS is a contentious technology embodying risks of c
This case study investigates the development of subject-specific literacy in Physical Education and Health (PEH) for second language (L2) learners within a Swedish secondary school context. Integrating Systemic Functional Linguistics (SFL) and Legitimation Code Theory (LCT), the study introduces the concept of embodied cohesion to analyze how meaning is constructed across verbal, graphic, and phys
In order for any learning-based model to be considered reliable, it needs a well-behaved uncertainty or confidence estimate. Most modern neural networks do produce a confidence estimate in the form of their softmax output probability. However, the softmax probability is invalid for out-of-distribution data. Gaussian processes are known to produce a well-behaved confidence estimate that is aware of
In recent years, Predictive Digital Twins (PDT) have emerged as a potential tool to monitor and predict the behavior of dynamic systems, including nature-based solutions in natural coastal systems. Here, we test the potential of using a simple, coupled shoreline and beach-dune model as a base for a PDT. The models exchange sediment flux balance information at each time step and recalculate shoreli
Antipsychotic drugs (APD) are commonly prescribed to people living with dementia (PwD) to manage behavioral and psychological symptoms of dementia (BPSD), despite well-documented safety concerns. International guidelines recommend non-pharmacological interventions as first-line treatment, yet APDs remain widely used. This systematic review and meta-analysis synthesize current evidence on the conse
Standardized Care Pathway (SCP) for patients presenting with macroscopic haematuria was introduced in Sweden in 2015. In contrast to neighbouring countries, the Swedish model includes all patients with macroscopic haematuria above the age of 50, notwithstanding obvious causes. The aim of this study was to characterize the patients referred within the SCP and the presence of acute cystitis.All pati
Postural orthostatic tachycardia syndrome (POTS) as conventionally defined is a chronic condition (typically >3 months duration) incorporating reproducible symptoms of orthostatic intolerance (including dizziness/lightheadedness, and near-syncope) in the absence of orthostatic hypotension (i.e., absence of a sustained systolic blood pressure drop >20mmHg with upright posture). 1-10 More recently
Background: Children and adolescents with autism spectrum disorder (ASD) are generally more sedentary and engage less in physical activity (PA) than their peers. Despite increasing evidence of benefits, practical guidance on implementing adapted PA programs in real-world settings remains limited. This study aimed to document iterative adaptations, implementation processes, and participant experi
INFORM is a prospective, multi-national registry gathering clinical and molecular data of relapsed, progressive or high-risk pediatric cancer patients. This report describes long-term follow-up of 519 patients in whom molecular alterations were evaluated according to a pre-defined 7-scale target prioritization algorithm. Mean turnaround time from sample receipt to report was 25.4 days. The highest
Purpose This study reports on the development of an auditory passage comprehension task for Swedish primary school children of cultural and linguistic diversity. It also reports on their performance on the task in quiet and in noise. Method Eighty-eight children aged 7-9 years and showing normal hearing participated. The children were divided into three groups based on presumed language exposure:
Energy communities are emphasized by the EU as important for developing sustainable energy systems that include and engage many people. While many renewables are highly compatible with a more decentralized energy system, research indicates that participation in 'desirable' energy activities and energy decision-making is influenced by social and economic factors, including gender, economic status a
This study develops the method for solution of inverse heat conduction problem applied to metal cutting. The proposed method operates with a selection procedure involving iterative solutions of heat forward problem. In such formulation, it allows avoiding difficulties associated with ill-posed inverse problems inherent to conventional formulations. Inverse heat problem was transformed into constra
Background: The ABILHAND questionnaire is recommended to assess perceived manual ability after stroke; however, more knowledge on interpretability is needed to improve the clinical applicability. Objectives: To determine clinically meaningful cutoff scores for different levels of perceived manual ability, assessed by ABILHAND, corresponding to established observed and perceived upper extremity ass
The thesis work concerns development and application of four versatile nonlinear optical techniques, based on exploiting ultrashort laser pulses, for diagnostic purposes in gases and flames. The four techniques, all laser-based, are two-photon laser-induced fluorescence (TPLIF), hybrid femtosecond/nanosecond (fs/ns) rotational coherent anti-Stokes Raman scattering (fs/ns RCARS), fs-laser-induced g
