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Immunotherapy has brought hope for cancer treatment, but its clinical success remains limited. Recently, overexpression of the transcription factors PU.1, IRF8 and BATF3 (PIB) was shown to induce direct reprogramming of tumor cells into antigen-presenting type 1 conventional dendritic cells (cDC1s), a rare subset of immune cells with pivotal role in anti-cancer immunity. This strategy might open a

Varje minuts fördröjning av hjärt-lungräddning minskar chansen till överlevnad med 10 procent, skriver åtta forskare vid Centrum för hjärtstopp vid Lunds universitet.Eight researchers at the Lund University Center for Cardiac Arrest write that every minute of delay in cardiopulmonary resuscitation reduces the chance of survival by 10 percent.

Background: Bioactive adrenomedullin (bio-ADM) is a vasoactive peptide with a key role in reducing vascular hyperpermeability and improving endothelial stability during infection, but it also has vasodilatory properties. Bioactive ADM has not been studied in conjunction with acute respiratory distress syndrome (ARDS), but it has recently been shown to correlate with outcomes after severe COVID-19.

Recent years have brought new directionality to university’s work with innovation – increasing the focus on addressing societal challenges and contributing to much broader frames for impact. Working with complex challenges, where no one actor can do everything by themselves, requires collaboration across actor groups (private sector, academia, public sector, civil society), industrial sectors, dis

Introduction: A subgroup of severe Traumatic Brain Injury (TBI) patients, known as ultra-severe (us-TBI), is most commonly defined as a post-resuscitation Glasgow Coma Scale (GCS) of 3–5. There is uncertainty on whether these critically injured patients can benefit from neurosurgical intervention. Research question: The available evidence regarding the decision-making and outcome following managem

Modern vibrational spectroscopy techniques enable the rapid collection of thousands of spectra in a single hyperspectral image, allowing researchers to study spatially heterogeneous samples at micrometer resolution. A number of algorithms have been developed to correct for effects such as atmospheric absorption, light scattering by cellular structures and varying baseline levels. After preprocessi

Popular Abstract in Swedish Anhöriga – aspekter på börda, livstillfredsställelse och effekter av stöd. Med en ökande befolkning av äldre och en samtidig minskning av möjligheter till hjälpinsatser inom såväl kommunalt som landstingsstyrd vård och omsorg, kommer många av oss ta hand om äldre familjemedlemmar, släktingar och vänner. Hur kommer detta att påverka oss? Ungefär 20 % av den vuxna befolWith an aging population and a reduction in social services provided by the municipality, a huge majority of us will take care of elderly family members, relatives and friends in need of assistance. How will this affect our lives? Approximately 20% of the adult population in Sweden, mainly middle-aged persons, identify themselves as family caregivers. Many of these caregivers are working and, at

Wireless access technologies such as UMTS with HSPA extensions, WiMAX, and Flash-OFDM and the convergence towards next generation heterogeneous networks enable the realization of always best connected scenarios. As the resulting heterogeneous networks become easier to access and more reliable to depend on, novel telemedicine services such as vehicular emergency applications emerge. Due to their li

The main information in DNA is its four-letter sequence that builds up the genetic information and that is traditionally read using sequencing methodologies. DNA can, however, also carry other important information, such as epigenetic marks and DNA damage. This information has recently been visualized along single DNA molecules using fluorescent labels. Quantifying fluorescent labels along DNA is

Popular Abstract in Swedish De svenska framtidsuttrycken (futuralt presens, futuralt skola och futuralt komma) är alla kontextuellt betingade användningar av uttryck som också har andra funktioner. Syftet med min avhandling är att beskriva vilka kontextvillkor som måste vara uppfyllda för att de tre uttrycken ska fungera som framtidsuttryck. I den modell över svenskans temporala system som presentThe main aim of this study is to specify the contextual conditions that apply to the use of the three central expressions for the future in Swedish: the present form and the auxiliaries skola and komma. A tense suffix indicates a temporal domain and states that a mediating element, here called FIX, is placed in the indicated domain. The present suffix points to a domain that overlaps temporally wi

Background: Hosts are often simultaneously infected with several parasite species. These co-infections can lead to within-host interactions of parasites, including mutualism and competition, which may affect both virulence and transmission. Birds are frequently co-infected with different haemosporidian parasites, but very little is known about if and how these parasites interact in natural host po

This text discusses the transformations of the Katyn memorial site near Smolensk in western Russia, where, in 1940, the mass murder of more than 4,000 Polish military officers who were prisoners of war occurred. After the Soviet Union’s admission of guilt in 1990, it seemed for two decades that Katyn could also serve as a place for mutual reconciliation between post-communist Poland and post-Sovie

In upholstery applications, it is common to use polyurethane (PUR) foam when flexibility is desired. However, as PUR is a carbon-based material produced using toxic isocyanates, it is environmentally beneficial to replace PUR with bio-based alternatives. The challenge, however, lies in finding suitable bio-based replacement materials, capable of mimicking the foam-like functionality of PUR since m

Background: Communication with patients and families about serious illness impacts quality of life and helps facilitate decision-making.Objective: To elucidate the pattern of communication about serious illness for patients who have died in an inpatient setting.Design: Three hundred patients from the Swedish Registry of Palliative Care 2015-2017 were randomly selected for manual chart review.Setti

Recombination strongly impacts sequence evolution by affecting the extent of linkage and the efficiency of selection. Here, we study recombination over the Z chromosome in great reed warblers (Acrocephalus arundinaceus) using pedigree-based linkage mapping. This species has extended Z and W chromosomes (“neo-sex chromosomes”) formed by a fusion between a part of chromosome 4A and the ancestral sex

Background: Chronic breathlessness adversely impacts people with chronic obstructive pulmonary disease and their caregivers (family and friends), who may, in turn, experience significant burden due to their caregiving role. Sustained-release morphine may reduce chronic breathlessness in some patients, which may have an impact on caregivers’ perceived burden. Aim: To explore the impact on caregiver

Background In adults with serious respiratory illness, breathlessness is prevalent and associated with reduced health-related quality of life. The aim of this review was to assess the impact of breathing techniques on breathlessness in adults with serious respiratory illness. Methods Electronic databases were searched to identify randomised controlled trials testing breathing techniques (technique