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The ATLAS experiment at the Large Hadron Collider has a broad physics programme ranging from precision measurements to direct searches for new particles and new interactions, requiring ever larger and ever more accurate datasets of simulated Monte Carlo events. Detector simulation with Geant4 is accurate but requires significant CPU resources. Over the past decade, ATLAS has developed and utilized
Background: Targeted therapeutic mild hypercapnia may attenuate brain injury in comatose adults resuscitated from out-of-hospital cardiac arrest. Objective: To describe the study protocol and statistical analysis plan for the Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) trial. Design, setting, participants and interventions: TAME is a phase 3, multicentre, paralle
Background: Current evidence suggests that use of intracoronary imaging during percutaneous coronary intervention (PCI) of the left main coronary artery (LMCA) reduces mortality. However, there is a scarcity of data on the overall role of intracoronary imaging, particularly in other non-LMCA proximal coronary artery lesions. We aimed to investigate the association of use of intracoronary imaging o
Non-lethal infections are common in free-living animals and the associated sickness behaviours can impact crucial life-history trade-offs. However, little is known about the duration and extent of such sickness behaviours in free-living animals, and consequently how they affect life-history decisions. Here, free-living Eurasian blackbirds, Turdus merula, were immune-challenged with lipopolysacchar
Monitoring insects of different species to understand the factors affecting their diversity and decline is a major challenge. Laser remote sensing and spectroscopy offer promising novel solutions to this. Coherent scattering from thin wing membranes also known as wing interference patterns (WIPs) have recently been demonstrated to be species specific. The colors of WIPs arise due to unique fringy
We have developed high-throughput tests for the detection of the insulin gene region SNPs -23HphI and -2221MspI. The potential of these markers to enhance the efficiency of type I diabetes risk screening was then evaluated by analyzing them in Finnish and Swedish populations. Blood spots on filter paper were analyzed using PCR followed by sequence- specific hybridization and time-resolved fluorome
Purpose: This study aimed to examine how young people living with Home Mechanical Ventilation experience the transition from childhood to young adulthood in relation to everyday life, perceived health and transition into adult professional healthcare. Methods: Nine young adults (three females and six males aged 18–31) were interviewed, and data was primary analysed using phenomenological hermeneut
The emergency department is a stressful environment, in which physicians are required to make fast and accurate diagnostic assessments amidst an ever increasing flood of clinical information, including a growing body of medical knowledge. Meanwhile, the digitization of medical health records in combination with recent breakthroughs in Artificial Intelligence is ushering in a new era of precision m
Background: Alcohol use disorder (AUD) is associated with an enormous burden of disease and cost to society. The dopamine deficiency hypothesis posits that negative reinforcement generated by a low brain dopamine state drives ethanol intake. Here, we evaluated the efficacy and safety of combined administration of two dopamine-enhancing drugs, varenicline (a partial nicotinic acetylcholine receptor
Advanced instrumentation and versatile setups are needed for understanding light interaction with biological targets. Such instruments include (1) microscopes and 3D scanners for detailed spatial analysis, (2) spectral instruments for deducing molecular composition, (3) polarimeters for assessing structural properties, and (4) goniometers probing the scattering phase function of, e.g., tissue slab
Significant efforts are ongoing to develop refined differentiation protocols to generate midbrain dopamine (DA) neurons from pluripotent stem cells (PSCs) for application in disease modeling, diagnostics, drug screening, and cell-based therapies for Parkinson's Disease (PD). An increased understanding of the timing and molecular mechanisms promoting the generation of distinct subtypes of human mid
INTRODUCTION: Many depressed patients do not achieve remission with available treatments. Anhedonia is a common residual symptom associated with treatment resistance as well as low function and quality of life. There are currently no specific and effective treatments for anhedonia. Some trials have shown that dopamine agonist pramipexole is efficacious for treating depression, but more data is nee
Popular Abstract in Swedish Bröstcancer är den mest frekventa cancerformen bland kvinnor, 1 av 8 drabbas någon gång under sin livstid av sjukdomen. Införandet av mammografi har gjort att cancern upptäcks tidigare och detta, tillsammans med effektivare behandlingsformer, har bidragit till att dödligheten i bröstcancer sjunkit de senaste decennierna. Antalet fall av bröstcancer ökar dock ständigt, fBreast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in females worldwide. Breast tumours are extremely heterogeneous, and each patient’s disease has different causes, prognosis and appropriate treatments associated with it. To enable a more individualised therapy, there is a substantial need for better characterisation of tumours and a deeper understanding o
Topic-independent expressions for conveying agreement and disagreement were annotated in a corpus of web forum debates, in order to evaluate a classifier trained to detect these two categories. Among the 175 expressions annotated in the evaluation set, 163 were unique, which shows that there is large variation in expressions used. This variation might be one of the reasons why the task of automati
A novel photodynamic therapy system based on interstitial illumination using multiple fibres is under development. The aim with this system is to enable treatment of large tumour volumes and also to utilise real-time measurements to allow on-line dosimetry. Important dosimetric parameters to measure are light fluence rate, sensitizer fluorescence intensity and local blood oxygenation. A constructi
Popular Abstract in Swedish Den arbetsrehabilitering som traditionellt erbjuds personer med psykisk funktionsnedsättning kan beskrivas som en trappa där varje steg består av olika åtgärder för att öka personernas arbetsförmåga. Målet är att personerna successivt skall bli friskare, öka sin funktionsnivå och utveckla fler färdigheter innan de kan ta steget ut till ett konkurrensutsatt arbete. För pIn the light of the limited research on the subject of Individual Placement and Support (IPS) in a Swedish context, this thesis has contributed with knowledge of the effectiveness and experiences of IPS among persons with severe mental illness (SMI) living in Sweden. The thesis has also provided information about the work motivation among those persons with SMI who seek vocational support by IPS.
Popular Abstract in Swedish Internet har under de senaste tio åren växt från marginalföreteelse till ett populärt och mycket använt medium. Många företeelser och tjänster tar steget över till Internet och bland dessa finns även journalistik. I fokus för denna avhandling står förändringsprocesser för journalistikens villkor, ideal och normer när nyhetsjournalistiken bedrivs på?Internet studerade utDuring the last decade the Internet has become a widely used source of information for the average person and also a publishing tool for media corporations. The transition of journalism from one medium to another is one with important implications as the world wide public consumption of online news grows. This dissertation puts focus on how journalistic content changes when it's published on the W
The new Civil Protection Act takes a more holistic view at accident prevention and protection than previous fire and safety regulations. The level of detailed regulation has decreased and national performance objectives have been formulated instead. The main purpose of this report is to present proposals for how municipalities, systematically and effectively, can plan and conduct inspection activi
Chronic inflammation may be involved in combat-related post-traumatic stress disorder (PTSD) and may help explain comorbid physical diseases. However, the extent to which combat exposure per se, depression, or early life trauma, all of which are associated with combat PTSD, may confound the relationship between PTSD and inflammation is unclear.
Antibody microarray is a novel technology with great promise within proteomics. Intense work is under way to evolve this methodology into the high-throughput proteomic research tool needed by the research community. Despite recent advances, there is a growing need for additional highperformance substrates for antibody microarrays as well as for protein arrays in general. In this study, we have suc
