Search results

Background: Matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) are colocalized to lipid-laden macrophages, and play a central role in initiation and propagation of chronic vascular diseases including atherosclerosis. Prior cross-sectional studies from our centre on children and adolescents with type 1 diabetes suggested possible propensity conferred by diabetes-risk HLA DQ2/8, particularly

Background: To date, targeted temperature management (TTM) is the only neuroprotective intervention after resuscitation from cardiac arrest that is recommended by guidelines. The evidence on the effects of TTM is unclear. Methods/design: The Targeted Hypothermia Versus Targeted Normothermia After Out-of-hospital Cardiac Arrest (TTM2) trial is an international, multicentre, parallel group, investig

Background: This study is designed to provide detailed knowledge on cognitive impairment after out-of-hospital cardiac arrest (OHCA) and its relation to associated factors, and to validate the neurocognitive screening of the Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest trial (TTM2-trial), assessing effectiveness of targeted temperature management after OHC

Digital practices in later life are not yet well understood. Therefore, this paper discusses the framework for a research design project that aims at tracing differences and similarities in how older adults use their smartphones in circumstances in and outside their homes in Spain, the Netherlands, Sweden, and Canada. The research questions of this international research project focus on the exten

Methods to involve users in design have long been used to create relevant content and increase the accuracy of product development. Demographic trends have raised the issue of the needs and demands of older people, especially with regard to digitization. In contrast to the high number of publications discussing the importance of involving people in the design of their daily life, very few publicat

The existing information supports the use of this material as described in this safety assessment. Dihydrocarvyl acetate was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data from read-across analogs dihydrocarveol (isomer unspecified) (CAS # 619-01-2) and aceti

Primary prevention of type 1 diabetes (T1D) requires intervention in genetically at-risk infants. The Global Platform for the Prevention of Autoimmune Diabetes (GPPAD) has established a screening program, GPPAD-02, that identifies infants with a genetic high risk of T1D, enrolls these into primary prevention trials, and follows the children for beta-cell autoantibodies and diabetes. Genetic testin

The NNBAR experiment for the European Spallation Source will search for free neutrons converting to antineutrons with an expected sensitivity improvement of three orders of magnitude compared to the last such search. This paper describes both the simulations of a key component for the experiment, the neutron optical reflector and the expected gains in sensitivity.

Three main paths are being developed within the ELI research program for transforming driving laser pulses into bursts of bright short wavelength radiation: high-order harmonic generation in gases, plasma X-ray sources and sources based on relativistic electron beams accelerated in laser plasma. For each of these research areas, dedicated beamlines are built to provide a unique combination of X-ra

There are competing standards regarding the definition of the crime of “enforced disappearance” under international law. When criminalizing enforced disappearance at the national level as part of their obligations under international law, States which adopt a more narrow definition of enforced disappearance provided in the Rome Statute require victims of enforced disappearance to prove the existen

Popular Abstract in Swedish Avhandlingen Optimization of Low-Level Controllers and High-Level Polymer Grade Changes är inom ämnesområdet reglerteknik. Det centrala i ämnet reglerteknik är att styra ett system, såsom en motor, ett teleskop eller en kemisk reaktor, så att det uppför sig på ett önskvärt sätt. Detta görs genom att använda mätningar av systemet, en algoritm som beräknar hur systemet sTwo design problems at different levels in the control hierarchy are considered; optimization of robust low-level controllers with constrained control signal activity and optimization of economical high-level polyethylene grade changes. As for the first design problem, a constraint on control signal activity due to measurement noise is presented and used when optimizing and comparing PI/PID contr