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The incretin - glucose-dependent insulinotropic polypeptide (GIP) - and the pro-inflammatory cytokine osteopontin are known to have important roles in the regulation of adipose tissue functions. In this work we show that GIP stimulates lipogenesis and osteopontin expression in primary adipocytes. The GIP-induced increase in osteopontin expression was inhibited by the NFAT (the transcription factor
Background: Long-term exposure to air pollution is a hypothesized risk factor for ischemic stroke. In a large case-control study with a complete study base, we investigated whether hospital admissions for ischemic stroke were associated with residential concentrations of outdoor NOx, as a proxy for exposure to air pollution, in the region of Scania, Southern Sweden. Methods: We used a two-phase ca
Background: Cohort studies of the relationship between air pollution exposure and chronic health effects require predictions of exposure over long periods of time. Objectives: We developed a unified modeling approach for predicting fine particulate matter, nitrogen dioxide, oxides of nitrogen, and black carbon (as measured by light absorption coefficient) in six U.S. metropolitan regions from 1999
A bioanode with high current density and coulombic efficiency was developed by co-immobilization of pyranose dehydrogenase from Agaricus meleagris (AmPDH) with the dehydrogenase domain of cellobiose dehydrogenase from Corynascus thermophiles (recDHCtCDH) expressed recombinantly in Escherichia coli. The two enzymes were entrapped in Os-complex modified electrodeposition polymers (Os-EDPs) with spec
BackgroundDimethyl sulfoxide (DMSO) is essential for the preservation of liquid nitrogen-frozen stem cells, but is associated with toxicity in the transplant recipient. Study Design and MethodsIn this prospective noninterventional study, we describe the use of DMSO in 64 European Blood and Marrow Transplant Group centers undertaking autologous transplantation on patients with myeloma and lymphoma
Background and purpose. The purpose of this study was to evaluate the performance of gantry angle optimisation (GAO) compared to equidistant beam geometry for two inverse treatment planning systems (TPSs) by utilising the information obtained from a range of treatment plans. Material and methods. The comparison was based on treatment plans generated for four different head and neck (H&N) cance
The standard model (SM) of particle physics is spectacularly successful, yet the measured value of the muon anomalous magnetic moment (g - 2)mu deviates from SM calculations by 3.6 sigma. Several theoretical models attribute this to the existence of a "dark photon," an additional U(1) gauge boson, which is weakly coupled to ordinary photons. The PHENIX experiment at the Relativistic Heavy Ion Coll
Context The relationship of platelet function testing measurements with outcomes in patients with acute coronary syndromes (ACS) initially managed medically without revascularization is unknown. Objective To characterize the differences and evaluate clinical outcomes associated with platelet reactivity among patients with ACS treated with clopidogrel or prasugrel. Design, Setting, and Patients Pat
This report focuses on models of chloride ingress into concrete that are based on mathematical solutions of Fick's second law. In recent years a lot of confusion has been identified concerning these models. In some cases time-dependencies of diffusivity have been used in a mathematically incorrect way. In other cases field and laboratory data from one way of describing the time-dependency of these
Predicted alterations in belowground plant-allocated C as a result of environmental change may cause compositional shifts in soil microbial communities, and it has been hypothesized that such alterations will influence C mitigation in forest ecosystems. In order to investigate to what degree living trees influence the abundance and activity of mycorrhizal fungi, saprotrophic fungi, and bacteria we
For centuries, people have appreciated the taste of wild mushrooms which can be found in nature throughout the European continent and the Fennoscandian peninsula. This is especially so for those of the order of Cantharellales, where you find the Golden Chanterelle among others. Today the commercial aspect of mushroom harvesting has resulted in regulations and guidelines set out by the Nordic Counc
With the rise of serious environmental threats brought about by climate change, governments, organizations, leaders, and academics are constantly seeking ways to address this growing concern, and the development of a circular economy model is seen as a viable solution towards ensuring environmental sustainability alongside economic growth. The concept of circular economy has been defined in a mult
According to the 1951 Refugee Convention, it is the state’s responsibility to protect and provide basic services to the refugees within their border. However, even if ratified to the Convention, it is common that the state decides to relinquish its responsibilities for various reasons. In Trinidad and Tobago, no national refugee policy has been adopted since the ratification of the 1951 Refugee Co
The study aims to understand how the national cultures influence the approaches of Alfa Laval and Camozzi Automation Group to ethical sustainability. It provides insights into the diverse strategies employed by companies in different cultural contexts. The purpose is to give actionable insights for businesses seeking to navigate the complex landscape of ethical responsibility.
Seeing how climate change disproportionately affects women and children, the voices of young people and women are vital to incorporate into discussions and decision-making processes regarding climate change. This thesis explores the experiences of young women in the climate movement who have participated at the COP climate conferences between 2015-2023. By drawing on the theoretical framework of f
The recycling sector and the solid waste management systems (SWMS) in developing countries greatly rely on scavengers, a vulnerable and marginal urban population that recover items or materials to be reused or recycled. As a new mindset towards waste emerges, considering it a resource instead of something useless and undesirable; governments, NGOs, private companies and other stakeholders slowly r
In the wake of the globalization, international tax planning structures has become vital for US investors in order to meet economic challenges and to survive on the competitive market. This research indicates that countries in Europe, such as Sweden and Switzerland, provide a favourable environment for US multinational corporations to set up holding companies as a way to enjoy benefits of legal ta
The thesis explores how the political discourse on refugees and asylum seekers is produced within portfolio committee meetings at the South African parliament. A critical discourse analysis investigates how statements of delegates of the Department of Home Affairs and Social Development foster unequal power relations and construct social identities perpetuating the on-going discourse on refugees a
Semantic Web technology has attracted much interest for its ability to integrate and deliver information from different sources, and increasingly, geodata are being published as triple data according to the graph structure laid out in the Resource Description Framework (RDF). Although the Semantic Web already contains a large volume of geotagged information, there is still a lack of suitable geome
