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INTRODUCTION: Pretangle tau inclusions from the locus coeruleus (LC) are hypothesized to propagate to the entorhinal cortex (EC) via neuron-to-neuron transmission along its projections. The lower integrity of the LC-EC pathway accompanying Alzheimer's disease (AD) pathology is supported by post mortem studies, but in vivo evidence remains limited. METHODS: We associated diffusion-weighted 7T magne
Purpose – Our research examines the impact of Islamic religiosity, exploring the role of religious actors, religious ideas (knowledge-based religiosity) and religious practice, on the involvement in early-stage entrepreneurial activity at the provincial level in Indonesia. Design/methodology/approach – We rely on the survey conducted by Global Entrepreneurship Monitoring in Indonesia, spanning fro
Non-invasive methods for measuring thermal tolerance and thermoregulation in large numbers of individuals under natural environmental conditions are useful to understand the capacity of species to adapt to future climate scenarios. Infrared thermography (IRT) is one such tool in research on thermal adaptation, but concerns have been raised about its reliability, specifically the correlation betwee
Background: The purpose of this study was to analyse if there is a relationship between the directions of windswept hip deformity and scoliosis for children with cerebral palsy (CP) and to explore potential associations with spasticity, contractures and hip displacement. Methods: A cross-sectional registry-based study was conducted using data from the combined Swedish CP Follow-up Program and Nati
Air pollution has become a widespread consequence of human activities, with increasing urbanization and a warming climate shaping its distribution and effects. Organisms with distinct respiratory systems and physiological traits are exposed to multiple air pollutants across human-modified environments, particularly in cities. However, much of our current understanding of how air pollutants affect
Skeletal muscle capillary density is correlated with physical performance and whole-body metabolic properties. Thus, we performed a genome-wide association study of skeletal muscle capillary-to-fiber ratio (C:F) (n = 603 males) and found that the rs115660502 G allele was associated (p < 5 × 10 -8) with increased C:F and reduced skeletal muscle expression of RAB3 GTPase-activating non-catalytic p
This article examines the explosion of artistic production in the Arab world during the so-called Arab Spring. Focusing on music, poetry, theatre, and graffiti and related visual arts, I explore how these do-it-yourself scenes represent, at least potentially, a return of the aura to the production of culture at the edge of social and political transformation. At the same time, the struggle to reta
Recent research has brought into focus the function of switching between verb forms and types of clauses, here labelled ‘gram switching’, as a device for marking non-main clause linking in various types of Arabic and in Biblical Hebrew (Persson forthcoming a; Isaksson, Kammensjö, and Persson 2009; Isaksson 2011, 2013). The study presented here shows that a switch, either in verb form/morphology or
Background: Gastrointestinal (GI) dysmotility and autonomic neuropathy are common problems among diabetics with largely unknown aetiology. Many peptides are involved in the autonomic nervous system regulating the GI tract. The aim of this study was to examine if concentrations of oxytocin, cholecystokinin (CCK), gastrin and vasopressin in plasma differ between diabetics with normal function and dy
We present a model for a feedback-controlled ratchet consisting of a Brownian particle and a moving, finite barrier that is shifted by an external agent depending on the position of the particle. By modifying the value of a single parameter of the feedback protocol, the model can act either as a pure rectifier, a power-stroke (PS) motor, or a combination of both. Interestingly, in certain situatio
Atmospheric nuclear weapons testing in the late 1950s and early 1960s almost doubled the amount of C-14 in the atmosphere. The resulting C-14 "bomb-pulse" has been shown to provide useful age information in e.g. forensic and environmental sciences, biology and the geosciences. The technique is also currently being used for retrospective cell dating in man, in order to provide insight into the rate
HLA-associated relative risks of type 1 (insulin-dependent) diabetes mellitus were analysed in population-based Swedish patients and controls aged 0-34 years. The age dependence of HLA-associated relative risks was assessed by likelihood ratio tests of regression parameters in separate logistic regression models for each HLA category. The analyses demonstrated an attenuation with increasing age at
Fast directional growth is a necessity for the young seedling; after germination, it needs to quickly penetrate the soil to begin its autotrophic life. In most dicot plants, this rapid escape is due to the anisotropic elongation of the hypocotyl, the columnar organ between the root and the shoot meristems. Anisotropic growth is common in plant organs and is canonically attributed to cell wall anis
Survival to extreme ages clusters within families. However, identifying genetic loci conferring longevity and low morbidity in such longevous families is challenging. There is debate concerning the survival percentile that best isolates the genetic component in longevity. Here, we use three-generational mortality data from two large datasets, UPDB (US) and LINKS (Netherlands). We study 20,360 unse
Dissemination of Bacillus anthracis from the respiratory mucosa is a critical step in the establishment of inhalational anthrax. Recent in vitro and in vivo studies indicated that this organism was able to penetrate the lung epithelium by directly entering into epithelial cells of the lung; however the molecular details of B. anthracis breaching the epithelium were lacking. Here, using a combinati
In this paper, we present the case of a couple who refused to disclose the sex of their child to others, and some of the responses that this case prompted in the international media. We outline the ethical issues that this case raises, and we place it into the more general context of parental preferences regarding the gender (development) of their children and of the impact on children of parental
