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Neurons are continuously generated from stem cells in the hippocampus and along the lateral ventricles in the adult brain. Neural stem cells can be propagated in vitro in the presence of epidermal growth factor (EGF) or fibroblast growth factor-2. We report here that amphiregulin, a growth factor related to EGF, is a mitogen for adult mouse neural stem cells in vitro and displays potency similar t
Huntington's disease (HD) is a devastating, neurodegenerative condition, which lacks effective treatment. Normal Huntingtin (HTT) and mutant Huntingtin (mHTT) are expressed in multiple tissues and can alter transcription of microRNAs (miRs). Importantly, miRs are present in a bio-stable form in human peripheral blood plasma and have recently been shown to be useful biomarkers in other diseases. We
High levels of ADAM17 activity have emerged as an important mediator in severe COVID-19. This study aims to characterize eventual causal relationships between ADAM17 and COVID-19. Using Mendelian randomization analyses, we examined the causal effects of circulating ADAM17 on COVID-19 outcomes using summary statistics from large, genome-wide association studies of ADAM17 (up to 35,559 individuals)
In order to study the effects of increasing age on the human skeletal muscle, cross-sections (15 micron) of autopsied whole vastus lateralis muscle from 43 previously physically healthy men between 15 and 83 years of age were prepared and examined. The data obtained on muscle area, total number, size, proportion and distribution of type 1 (slow-twitch) and type 2 (fast-twitch) fibers were analysed
BACKGROUND: Pharmaceutical expenditures (PE) are increasing worldwide raising concerns about sustainability. However, the current price index provides an incomplete picture of this trend due to the rapid introduction of new drugs on the market.OBJECTIVE: The aim of this study is to decompose PE into their components and investigate the development in Sweden from 1990 to 2022.METHODS: The PE index
Previous research showed that living closer to bus stops could be a factor in promoting a healthy and active lifestyle. However, most of the studies relied on self-reported measures of distance, which might be affected by several confounders. In this study, self-reported distances among study participants were compared to actual ones, computed by the use of GIS (Geographic Information System) tech
Title: Christmas is in the Air: A quantitative study on how sound and smell influence perception and the creation of attitudes Seminar date: 2015-01-15 Course: FEKH29, Degree Project Undergraduate level, Business Administration, Undergraduate level, 15 ECTS Authors: Per-Erik Persson, Tijana Stojanovic Advisor: Clara Gustafsson Key words: Sensory Marketing, attitude, visit intention, sce
EFL är en icke-vinstdrivande stiftelse som arbetar med vidareutbildning inom Ekonomihögskolan vid Lunds universitet. Stiftelsen grundades 1969 av professorer och lärare vid Företagsekonomiska institutionen. Styrelsen består idag av en huvudman: Ekonomihögskolan vid Lunds universitet. EFL:s verksamhet grundar sig på tanken om nära relationer mellan näringsliv och universitet. Idag finns ett regiona
This study examines how the sharing economy is utilized in an emerging area to promote social sustainability. Sege Park in Malmö provide this study's research area. This community served as a testbed for a Sharing Cities Sweden initiative, with support from Malmö municipality, to create a collaborative neighbourhood. The research contains a document analysis of official planning documents by M
