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In this position paper we argue for a radical departure from today's approach to software engineering, centered on target-specific tools and general processes such as modeling and agile practices. The old principle of right tool for each problem shall be applied to software engineering as well: to address ever higher complexity, we need to raise dramatically the level of abstraction; as general so

The strong negative relationship between geographical distance and trade is not well understood. I use the liberalization of the Soviet airspace to estimate the causal impact of business travel cost on trade. The liberalization radically reduced travel time between Europe and East Asia and was followed by a significant increase in trade. I find that the cost of business travel can account for a la

A search for the dimuon decay of the Standard Model (SM) Higgs boson is performed using data corresponding to an integrated luminosity of 139 fb−1 collected with the ATLAS detector in Run 2 pp collisions at s=13 TeV at the Large Hadron Collider. The observed (expected) significance over the background-only hypothesis for a Higgs boson with a mass of 125.09 GeV is 2.0σ (1.7σ). The observed upper li

Our global sustainability challenges are complex and require partnerships and collaboration across disciplines and sectors. As such, as a society, we must value interdisciplinary perspectives and work together to address these challenges. In this episode, we discuss the value of interdisciplinary education to address our complex sustainability challenges. We share the experience from our two inter

Vi presenterar skyddsåtgärder som vidtagits som en del av åtgärdsprogrammet ”Projekt Skräntärna” under perioden 2007–2020 i Sveriges största koloni, Stenarna i Björns skärgård, Uppland. En kombination av övervakning, forskning och förvaltningsåtgärder genomfördes enligt en flexibel strategi, där både etablerade och nya tekniker användes. Varje år under häckningssäsongen gjordes fyra besök för att WE PRESENT CONSERVATI ON ACTI ONS during 2007–2020 as part of the national Caspian Tern Hydroprogne caspia species action plan at Stenarna in the Björn archipelago, Uppland, the largest colony in Sweden. We applied a combination of monitoring, research, and management measures conducted within an adaptive approach frame-work, using both established and novel techniques. The implementation of conse

Knowledge of price formation in fisheries is important in understanding effects of fisheries regulations and the support or resistance to regulations from different stakeholders. This article studies how demand can be traced out using wind speed on a fishing trip. Wind speed is strongly correlated with the quantities of Norwegian lobster (Nephrops) available on the market. Using wind variables as

Recent findings support the hypothesis that inhibition of SMYD3 methyltransferase may be a therapeutic avenue for some of the deadliest cancer types. Herein, active site-selective covalent SMYD3 inhibitors were designed by introducing an appropriate reactive cysteine trap into reversible first-generation SMYD3 inhibitors. The 4-aminopiperidine derivative EM127 (11C) bearing a 2-chloroethanoyl grou

Objectives.: To assess the comparability of the Tandem-R and IMx serumprostate-specific antigen (PSA) assays across levels of the ratio of free-to-total serum PSA found in a community-based population of healthy men. Methods.: Banked serum samples from the baseline component of the Olmsted CountyStudy of Urinary Symptoms and Health Status Among Men were thawed and analyzed using the Tandem-R and I

We set up a tasting venue at a local supermarket and invited passerby shoppers to sample two different varieties of jam and tea, and to decide which alternative in each pair they preferred the most. Immediately after the participants had made their choice, we asked them to again sample the chosen alternative, and to verbally explain why they chose the way they did. At this point we secretly switch

Reduction of packaging waste has been a European target for more than 40 years. However, packaging is indispensable for protecting what it carries. In this study, an analysis of the European regulations on packaging and of their resulting effect on recycling performance was performed by means of a literature survey and the national results published in the European Database, Eurostat. Based on the

The dimeric metabolic enzyme phosphoglucose isomerase (PGI, EC 5.3.1.9) plays an essential role in energy production. In the grass Festuca ovina, field surveys of enzyme variation suggest that genetic variation at cytosolic PGI (PGIC) may be adaptively important. In the present study, we investigated the molecular basis of the potential adaptive significance of PGIC in F. ovina by analyzing cDNA s

Popular Abstract in Swedish Avhandlingen behandlar robotteknik och de nya möjligheter som den kan ge människor med rörelsehinder. Jag fokuserar på teknikanvändaren och teknikanvändningen, speciellt på vad som gör robothjälpmedel värda att använda. Distinktion görs mellan användvärdhet och användbarhet. Erfarenheter från användning av den rullstolsmonterade robotarmen Manus visar att tekniska kravThis thesis deals with robotics and the new possibilities it offers people with physical disabilities. I focus on the user and the use of the technology and, in particular, on what makes robotic aids worth using - useworthiness as distinguished from usability. User experience of the wheelchair-mounted Manus manipulator shows that robotic arms must meet technical requirements in terms of accelerat

Potential doubling time (Tpot), DNA synthesis time (TS), and labelling index (LI) are fundamental growth kinetics parameters in clinical and experimental cancer research, which may be of further practical importance regarding prognosis and treatment prediction of cancer. They can be measured by bromodeoxyuridine(BrdUrd)/flow cytometry (FCM) methods, where BrdUrd, an analogue of thymidine, is incor

Prediction of the in-plane biaxial strength of paper by the Tsai-Wu failure criterion has in general proved to be in good agreement with experimental data. However, the Tsai-Wu criterion overestimates the strength in some parts of the biaxial tension region. This shortcoming can be corrected by adding a pair of cubic terms to the existing Tsai-Wu criterion. The modified Tsai-Wu criterion presented

Growing demand for transport biofuels in the EU is driving an expansion of the industry in developing countries. Large-scale production of energy crops for biofuel, if mismanaged, could cause detrimental environmental and social impacts. The aim of this study is to examine whether the newly adopted EU Directive 2009/28/EC and its sustainability certification system can effectively ensure sustainab