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BackgroundCapsaicinoids are produced by plants in the Capsicum genus and are the main reason for the pungency of chili pepper fruits. They are strong agonists of TRPV1 (the transient receptor potential cation channel subfamily V member 1) and used as active ingredients in pharmaceuticals for the treatment of pain. The use of bioengineered microorganisms in a fermentation process may be an eff

The impact of different spark designs on the ignition and combustion stability is studied using a 13-liter CNG fueled heavy duty spark ignited engine to search for the “optimal” spark design. Experimental results show that robust ignition can be achieved using a significantly shorter spark duration and lower energy than expected. A capacitive discharge ignition (CDI) system enabled to separately

Introduction: Current drug treatment of lower urinary tract disorders, for example, overactive bladder syndrome and lower urinary tract symptoms associated with benign prostatic hyperplasia, is moderately effective, has a low treatment persistence and some short- and long-term adverse events. Even if combination therapy with approved drugs may offer advantages in some patients, there is still a ne

Development of molecular markers that help to identify high-risk individuals or diagnose indeterminate pulmonary nodules could have a major impact on lung cancer clinical management. In this study, we evaluated the diagnostic potential of a newly-developed ELISA that specifically detects complement C4d. We measured this marker in five independent cohorts of plasma and bronchoalveolar lavage sample

J Thromb Haemostas 2009;7(Suppl2):abstract 672. DOI: 10.1111/j.1538-7836.2009.03473_2.x

Resilience is a debated concept with numerous definitions. If focusing on describing a community under stress of a particular disruptive event, its more traditional etymological meaning of ability to spring back after deformation, or its more applied meaning of ability to cope with and recover from the event, are sufficient. However, if focusing on building and maintaining resilient communities ov

IMPORTANCE Although spouses strongly resemble one another in their risk for alcohol use disorder (AUD), the causes of this association remain unclear. OBJECTIVES To examine longitudinally, in first marriages, the association of a first registration for AUD in one spouse with risk of registration in his or her partner and to explore changes in the risk for AUD registration in individuals with multi

The purpose of this paper is to introduce the concept coworkers’ communicative responsibility taking and to test which factors might influence coworkers’ tendency to take communicative responsibility. The study is split into two phases where on exploratory phase consisted of an exploratory factor analysis on 2244 with the aim to find specific latent factors to test in the confirmatory phase. The c

The purpose of this report is to derive lessons from inflation targeting in Sweden for the choice of the future monetary policy regime of Iceland. Swedish inflation targeting has been a success in terms of reducing inflation and inflation volatility, but real economic volatility is not lower compared to previous periods. In addition, financial imbalances have grown rapidly. A key lesson is that th

We study the realizability and strong satisfiability problems for SAFETY LTL, a syntactic fragment of Linear Temporal Logic ([Formula presented]) capturing safe formulas. While it is well-known that realizability for this fragment lies in [Formula presented], the best-known lower bound is [Formula presented]-hardness. Surprisingly, closing this gap has proven an elusive task. Previous works have c

Following the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) treatment algorithm for chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP), patients suffering from severe uncontrolled CRSwNP are recommended to receive oral corticosteroids, (revision) sinus surgery, systemic biologicals and/or aspirin treatment after desensitization (ATAD). Given the major diff

Urban greening is often thought of as a tool for aligning developmental and environmental goals, but it is also a tool for magnifying the city. It exposes and expands almost invisible dimensions of our hyperlocal environment. Greening has become one of the strongest mechanisms for transforming these preferences from a figurative guide for action into the literal cities the authors inhabit. In the

Many grants from US funding agencies are restricted to US citizens or permanent residents which negatively impacts the career options for foreign scientists working in the USA. [Image: see text]

Amyloid-PET quantification through the tracer-independent Centiloid (CL) scale has emerged as an essential tool for the accurate measurement of amyloid-β (Aβ) pathology in Alzheimer's disease (AD) patients. The AMYPAD consortium set out to integrate existing literature and recent work from the consortium to provide clinical context-of-use recommendations for the CL scale. Compared to histopatholog