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Introduction: Biokinetic and dosimetry studies in small animals often precede clinical radionuclide therapies. As in human studies, a reliable evaluation of therapeutic efficacy is essential and must be based on accurate dosimetry, which must be based on a realistic dosimetry model. The aim of this study was to evaluate the differences in the results when using a more anatomic realistic mouse phan
A large number of rachopharmaceuticals labelled with C-11 (half-time 0.340 h) are being developed for positron emission tomographic studies of different types of receptor in the human brain. For most of these agents, the available biokinetic data are insufficient to construct realistic compound-specific biokinetic models for calculating the internal radiation dose delivered to persons undergoing i
The output factor for a therapy photon beam is defined as the dose per monitor unit relative to the dose per monitor unit in a reference field. Convolution models for photon dose calculations yield the dose in units normalized to the incident energy fluence with phantom scatter intrinsically modeled. Output factors calculated with the convolution method as the dose per unit energy fluence relative
We derive process limit distribution results for the Nelson–Aalen estimator of a hazard function and for the Kaplan–Meier estimator of a distribution function, under different dependence assumptions. The data are assumed to be right censored observations of a stationary time series. We treat weakly dependent as well as long range dependent data, and allow for qualitative differences in the depende
Recently, a test dealing with the linear hypothesis for the global minimum variance portfolio weights was obtained under the assumption of non-singular covariance matrix. However, the problem of potential multicollinearity and correlations of assets constitutes a limitation of the classical portfolio theory. Therefore, there is an interest in developing theory in the presence of singularities in t
Popular Abstract in Swedish Denna avhandling beskriver den centrala metabolismen och produktionen av exopolysackarider (EPS) hos två olika mjölksyrabakterier: Lactobacillus reuteri och Pediococcus parvulus. Mjölksyrabakterier används inom livsmedelsindustrin som startkulturer i olika mjölkbaserade produkter. Generellt utnyttjas en specifik metabol väg för nerbrytningen av sockerkällan till mjölksyThis thesis deals with the central carbohydrate metabolism and exopolysaccharide (EPS) formation in two different lactic acid bacteria (LAB): Lactobacillus reuteri and Pediococcus parvulus. LAB are traditionally used as starter cultures in the food industry. In general, LAB harbours one glycolytic pathway converting carbohydrates into lactic acid. However, L. reuteri ATCC 55730 was proven to use t
The aims of this study were to determine whether a registered nurse can collect information and plan a holistic and individual strategy for the treatment of patients with irritable bowel syndrome (IBS) and whether this approach can reduce these patients' health aspects. The referrals of 50 Swedish-speaking female patients aged between 18 and 65 years with the preliminary diagnosis of IBS were coll
History shows that companies that survive in a severe competitive climate are those that are highly adaptable to market and technological changes. Product development is one of the key activities that assure company survival by renewal of its offer to its customers. A scientific formalism has to be created to fulfill two purposes: 1) to ensure that the design and development of a product is succes
Let P be a set of n points in the Euclidean plane and let O be the origin point in the plane. In the k-tour cover problem (called frequently the capacitated vehicle routing problem), the goal is to minimize the total length of tours that cover all points in P, such that each tour starts and ends in O and covers at most k points from P. The k-tour cover problem is known to be NP-hard. It is also kn
This paper develops a more detailed understanding of when incumbent actors may become the main locomotive driving energy transitions. It also illustrates the trade-offs between policy approaches that actively seek to involve the incumbents in transitions, and policy approaches that pursue transitions without their active involvement. The paper examines state support for the bioeconomy in Sweden an
We describe key aspects of hypnosis that distinguish it from other psychotherapeuticapproaches, argue that hypnosis occupies a unique niche among clinical interventions, andclaim that a substantial body of evidence supports its use across a gamut of psychologicalconditions. Hypnotic techniques are ideally suited to present useful suggestions that canalter subjective, behavioral, and physiological
Fast-neutron/gamma-ray pulse-shape discrimination has been performed for the organic liquid scintillators NE 213A and EJ 305 using a time-of-flight based neutron-tagging technique and waveform digitization on an event-by-event basis. Gamma-ray sources and a Geant4-based simulation were used to calibrate the scintillation-light yield. The difference in pulse shape for the neutron and gamma-ray even
Basic materials are traded globally and responsible for roughly 22 % of global carbon emissions. It is technically possible for the energy intensive industries (EIIs) that produce these materials to reach zero emission, but at a cost. So far, the fear of carbon leakage has been a barrier for implementing ambitious domestic climate policies that targets theses globally traded commodities. The intr
Models for Non-Modelers focuses not on how to design models but on how to understand and critically appraise them. Data and statistical models are widely used in disciplines such as epidemiology, climate science and systems design, but it can be difficult for those without the necessary training to understand and implement them. This book is for non-modelers, especially social scientists. Through
Approaches integrating interdisciplinary perspectives are necessary to address current and future health and environmental challenges. Many policy initiatives have embraced more holistic approaches to tackle these challenges, e.g., the One Health concept, the Farm to Fork (F2F), Biodiversity and Chemical strategies within the European Green Deal and the global Sustainable Development Goals (SDGs).
