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Autologous hematopoietic stem cell transplantation (AHSCT) to treat multiple sclerosis (MS) has mostly been used in devastating cases as the last option to stop further neurological deterioration. However, evidence from several retrospective clinical trials indicates that young, less disabled patients with highly inflammatory active MS are the most likely to benefit from AHSCT, and after moving fr
We present a program to compute polarizabilities of nominal one-electron systems using the Lagrange-mesh method (LMM) (Baye, 2015), that was used by Filippin et al., (2018). A semiempirical-core-potential approach is implemented, ultimately solving a Dirac-like equation by diagonalizing the corresponding Hamiltonian matrix. In order to build the core potential, the core orbitals are obtained from
In recent years, quantitative approaches based on mathematical theories and ICT tools, known under the terms of digital, computational, and virtual archaeology, are more and more involved in the traditional archaeological research. In this paper, we apply shape analysis techniques to 3D digital replicas of archaeological findings to support their interpretation. In particular, our study focuses on
Prostate cancer is the second most common cause of cancer-related deaths in men, representing a major source of morbidity and mortality. Androgen deprivation therapy is the primary treatment for patients with advanced prostate cancer at disease presentation, which can be achieved either with surgical or chemical castration. The development of gonadotropin-releasing hormone agonists revolutionized
Background: Previous research shows that critical constructive feedback, that scaffolds students to improve on tasks, often remains untapped. The paper’s aim is to illuminate at what stages students provided with such feedback drop out of feedback processing. Methods: In our model, students can drop out at any of five stages of feedback processing: (1) noticing, (2) decoding, (3) making sense, (4)
Background: Depressive symptoms are common in rheumatic diseases and influence patients’ quality of life. The Patient Health Questionnaire-9 (PHQ-9), which assesses symptoms of depression, is valid in English in patients with systemic sclerosis (SSc). However, the measurement properties of the PHQ-8 (short version of the PHQ-9) have not been evaluated in Swedish patients with SSc. Objective: To in
We present an approach for the estimation of ore processing residue volumes in historical mine waste dumps by the use of different geophysical methods in combination with mineralogical investigations. The stamp mill dump in the Harz mountains, Germany was examined with the methods electrical resistivity tomography (ERT), ground penetrating radar (GPR) and spectral induced polarization (SIP) flanke
Implementation of Bridge weigh-in-motion (B-WIM) measurements and probabilistic approaches in bridge assessment may reveal hidden bridge reserves and changes in reliability levels over their projected service life, providing a key input for optimized bridge management. But, as scientists and engineers and at the same time vendors of our own ideas, we need to be in position to present the results o
The construction workflow of in-situ concrete frames in multi-storey residential buildings is highly complex and dynamic. Discrete-event simulation (DES) offers capabilities to model and analyse such complexity. Although DES has successfully been used by researchers in a wide range of construction-related applications there are not many examples demonstrating how different simulation outputs (time
Cross-border regions are characterised by many inherent challenges. Such challenges can include differences in languages, cultures, currencies, markets, labour market conditions, political visions and priorities, governance structures – to name but a few. Greater Copenhagen1 is no different in terms of the challenges it faces as a cross-border region.The aim of this study is to investigate the pos
Safety in density (SID) potentially explains the safety in numbers (SIN) phenomenon by positing that ‘the SIN effect can be reproduced simply through encouraging behaviour that leads to the formation of higher-density cyclist groups’. The study further explores this hypothesis using event-based exposure, queues and groups of road users. Using three different definitions of encounters between road u
CONTEXT: Once islet autoantibody-positive individuals are identified, predicting which individuals are at highest risk for type 1 diabetes (T1D) is important. A metabolic risk score derived from 2-hour oral glucose tolerance test (OGTT) data, the Diabetes Prevention Trial-Type 1 risk score (DPTRS), can accurately predict T1D. However, 2-hour OGTTs are time-consuming and costly. OBJECTIVE: We aimed
This study evaluated the suitability of the latest retrospective Integrated Multi-satellitE Retrievals for Global Precipitation Measurement V06 (IMERG) Final Run product with a relatively long period (beginning from June 2000) for drought monitoring over mainland China. First, the accuracy of IMERG was evaluated by using observed precipitation data from 807 meteorological stations at multiple temp
Objective: Neurological outcome prediction is crucial early after cardiac arrest. Serum biomarkers released from brain cells after hypoxic-ischaemic injury may aid in outcome prediction. The only serum biomarker presently recommended in the European Resuscitation Council prognostication guidelines is neuron-specific enolase (NSE), but NSE has limitations. In this study, we therefore analyzed the o
Purpose: Digital breast tomosynthesis (DBT) is a promising breast cancer screening tool that has already begun making inroads into clinical practice. However, there is ongoing debate over how to quantitatively evaluate and optimize these systems, because different definitions of image quality can lead to different optimal design strategies. Powerful and accurate tools are desired to extend our und
