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Epilepsy is one of the leading neurological disorders affecting not only patients who suffer from seizures but also people around them and society in general. The striking one third of patients not responding to pharmacological treatments implies the necessity of developing alternative options for controlling seizures in these individuals. Moreover, the possibility to stop the progression of the d
Objective: To develop a minimum core data set for evaluation of acute limb ischaemia (ALI) revascularisation treatment and outcomes that would enable collaboration among international registries. Methods: A modified Delphi approach was used to achieve consensus among international multidisciplinary vascular specialists and registry members of the International Consortium of Vascular Registries (IC
Purpose/Objective(s): To report the efficacy and utility of PSMA-based molecular targeted imaging in localized prostate cancer using 111In-J591 SPECT and 89Zr-J591 immuno-PET.Materials/Methods: Initiated in 2010, two sequential phase 0 prospective studies were performed on a total of 19 patients evaluating the roles of 111In-J591 SPECT and 89Zr-J591 immuno-PET. All patients had a baseline MRI foll
OBJECTIVE: To build mathematical models to evaluate the individual risk of endometrial malignancy in women with postmenopausal bleeding and sonographic endometrial thickness ≥ 4.5 mm using clinical data, sonographic endometrial thickness and power Doppler ultrasound findings. METHODS: Of 729 consecutive patients with postmenopausal bleeding, 261 with sonographic endometrial thickness ≥ 4.5 mm and
Background: Persons with dementia receive health care and social services from a wide range of professional care providers during the disease trajectory, presenting risks of miscommunication, duplication and/or missed nursing interventions. Accordingly, the aim of this study was to investigate professional care providers' views on conditions for best practice in terms of collaboration and improvem
A complex of chagasin, a protein inhibitor from Trypanosoma cruzi, and papain, a classic family C1 cysteine protease, has been crystallized. Kinetic studies revealed that inactivation of papain by chagasin is very fast (k(on) = 1.5 x 10(6) m(-1).s(-1)), and results in the formation of a very tight, reversible complex (K-i = 36 pm), with similar or better rate and equilibrium constants than those f
Background and problem: In October 2010 the European Commission issued a Green Paper on Audit Policy in which they set out to draw lessons of the auditors’ role in the recent financial crisis. The European Commission considers the function of the audit to be a key contributor to investor confidence and suggests a number of controversial measures with the aim of ensuring financial stability in the
The aim of this thesis was to reconstruct the Holocene vegetational and climatic development in the Sylarna-Storulvån area, western Jämtland, in the central Scandes Mountains. Temporal trends and fluctuations in the elevation and vegetational character of the tree-limit ecotone were studied mainly by means of pollen and plant macrofossil analysis of two lake sediment sequences (Lakes Stentjärn and
There is a lack of validated autism-specific outcome measures for large-scale evaluation of the effectiveness of psycho-educational programmes. To fill this gap the Environment Rating Scale (ERS) was adapted from an interview version to a staff-completed questionnaire version (ERS-Q). The ERS-Q was tested regarding data quality, validity, reliability and ease of understanding amongst 18 residentia
The VUCA world we face today, proposes challenges for individuals with a high Need for Closure (NFC) as they may experience decreased well-being when faced with uncertainty and ambiguity. This in turn creates a problem for organizations as their employees with a high NFC may struggle to come up with innovative solutions to the complexity they are facing, making it difficult for the organization to
This thesis critically explores gender equality in international development, focusing on Guatemala amidst resurgent right-wing politics, volatile commitment, and gender backlash. It investigates how institutions like the Food and Agriculture Organization (FAO) navigate gender mainstreaming in a country with fluctuating dedication to gender equality. Through mixed methods, including thematic analy
The advances in hematopoietic cell transplantation (HCT) over the last decade have led to a transplant-related mortality below 15%. Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a life-threatening complication of HCT that belongs to a group of diseases increasingly identified as transplant-related, systemic endothelial diseases. In most cases, SOS/VOD resolves within
Searches for new resonances are performed using an unsupervised anomaly-detection technique. Events with at least one electron or muon are selected from 140 fb−1 of pp collisions at √s ¼ 13 TeV recorded by ATLAS at the Large Hadron Collider. The approach involves training an autoencoder on data, and subsequently defining anomalous regions based on the reconstruction loss of the decoder. Studies fo
Heparan sulfate proteoglycans consist of a small family of proteins decorated with one or more covalently attached heparan sulfate glycosaminoglycan chains. These chains have intricate structural patterns based on the position of sulfate groups and uronic acid epimers, which dictate their ability to engage a large repertoire of heparan sulfate-binding proteins, including extracellular matrix prote
CD59 is a glycosylphosphatidylinositol (GPI)-anchored cell surface inhibitor of the complement membrane attack complex (MAC). We showed previously that CD59 is highly expressed in pancreatic islets but is down-regulated in rodent models of diabetes. CD59 knockdown but not enzymatic removal of cell surface CD59 led to a loss of glucose-stimulated insulin secretion (GSIS), suggesting that an intrace
Background: Studies on risk factors for severe COVID-19 in people of working age have generally not included non-working persons or established population attributable fractions (PAFs) for occupational and other factors. Objectives: We describe the effect of job-related, sociodemographic, and other exposures on the incidence, relative risks and PAFs of severe COVID-19 in individuals aged 18–64. Me
Within international investment law scholarship, increased attention has been devoted to the capacity of international investment law, which includes investment treaty arbitration, to facilitate sustainable development. Scholars increasingly agree that issues of sustainable development permeate throughout the international investment law system and thus cannot be viewed as beyond its scope and jur
