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Empiric combination antibiotic therapy (ECAT) is commonly used to treat healthcare-associated bloodstream infections (HA-BSIs) and sepsis. However, the level of supporting evidence is low and clinical practice varies significantly. We conducted a post hoc analysis using the EUROBACT-2 international cohort study database, which contained data on 2406 adult patients from 328 intensive care units (IC
Stormwater management is essential for preventing urban flooding and protecting water quality in receiving bodies. Traditionally viewed as a nuisance, stormwater is now being re-evaluated as an alternative resource for non-potable uses such as toilet flushing and irrigation through rainwater harvesting systems (RWHS). Within the European Union's Horizon 2020 project REWAISE, pilot studies with cer
Galactoglucomannan (GGM) has been identified as a valuable resource and can be used in fields such as oxygen barrier films, food coatings or hydrogels. This hemicellulose can be extracted from softwood using steam explosion (STEX) under mild conditions. However, the GGM-solution also contains impurities such as lignin, lignin-carbohydrate complexes, organic acids, and salts, which require further
Alternative food initiatives are vital for transforming food systems towards sustainability by challenging, replacing, and complementing the status quo. Understanding how these initiatives contribute to transformation requires attention not only to their intended outcomes but also to the processes through which these outcomes contribute to broader social change. Existing assessment frameworks rare
INTRODUCTION: There is substantial heterogeneity in the reporting of outcomes in the global cranioplasty literature. This study aimed to establish a core outcome set (COS) for cranioplasty after decompressive craniectomy for stroke or traumatic brain injury.METHODOLOGY: The scope was defined according to the criteria recommended by the Core Outcome Measures in Effectiveness Trials (COMET) Initiati
This paper explores the challenges and barriers of forced migrants at the nexus of housing and social integration, presenting the outcomes of an international and interdisciplinary collaboration funded by the JPI Urban Europe programme. Research includes the case study cities Leipzig, Lund, Riga, and Vienna, utilizing primary and secondary data in a transdisciplinary process involving theoretical
Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy (MAIHDA) is a multilevel regression approach grounded in intersectionality theory. It examines inequalities across intersections of social identities (e.g., gender, ethnicity, class) and is argued to provide more accurate predictions of intersectional means than conventional methods that estimate group means directly or vi
For circular retail models to successfully replace linear consumption in the future, retailers must understand the lived reality of second-hand customer journeys. However, existing customer journey mapping methods often fail to capture the non-linear, phygital, and multi-retailer nature of such journeys. This article introduces ‘messy customer journey self-mapping’, a novel qualitative method desi
INTRODUCTION: Autoantibodies against insulin (IAA) are early appearing markers of autoimmunity against the pancreatic islet beta cells and predict progression to type 1 diabetes if additional islet autoantibodies also develop. It is still controversial if proinsulin rather than insulin is the primary autoantibody.METHODS: The aim of the present study was to compare the half-maximal concentration (
The fields of cultural tourism and heritage management are gaining attention for their potential to be better linked, particularly in terms of practical applications. This paper proposes a taxonomy of heritage resources and related heritage-based tourism types and their linkages for specific case study areas, building on the established product class approach in cultural tourism studies. The resea
During evolution the human brain has increased drastically in size compared to that of other primates. However, little is known about primate brain development as it is difficult to study human and primate brains in the laboratory due to the scarcity of tissues. Yet, it is essential to study primate brains and understand the molecular features leading to the human brain’s unique cognitive function
By the end of the 1960s there was a growing environmental concern all around the globe. As a part of an answer to this challenge the need was recognized for a reorientation of the education processes towards developing knowledge, attitudes and skills for resolving the issues. This was the birth of the concept of Environmental Education (EE). However, this notion is far from being static as it went
Purpose of study: As both innovations and brand loyalty are becoming ever more important for companies today, it is of importance to understand how an organisation can handle the relationship between the explorative and exploitative units when working with these two constructs. The ultimate aim is to understand how service organisations can be managed in order to enhance brand loyalty through serv
Positive aspects of fathers’ involvement in parenting are broadly recognized, but challenges faced by fathers are often neglected and postpartum depression (PPD) is still mainly considered as a problem of mothers. Yet, new evidence suggests a similar prevalence of about 10 % in fathers and mothers. The present study investigated paternal PPD, its character and its links to attachment styles, paren
The communicating home concept has been defined by identifying the dominating communication technologies to/from and in the homes, the most important customer behavior and user needs, the dominating products and the dominating actors of the industry. The evaluation of the communicating home industry has been performed with a five forces framework analysis and theories regarding value migration and
Problem: Since business process management (BPM) is a very spacious concept, it is influenced from many other concepts, standards and methods that determine its constancy. Companies are asked to restructure their organisation in order to meet internal and external customer demands. The term quality comes to the fore. Organisations such as ISO and the EFQM try to certify or assess companies in term
