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L-DOPA is the gold-standard treatment for Parkinson's disease (PD), but induces troublesome dyskinesia after prolonged treatment. This is associated with the 'false neurotransmitter' conversion of L-DOPA to dopamine by serotonin neurons projecting from the raphe to the dorsal striatum. Reducing their activity by targeting pre-synaptic 5-HT1A receptors should thus be an attractive therapeutic strat
We determined whether single nucleotide polymorphisms (SNPs) previously associated with diabetogenic traits improve the discriminative power of a type 2 diabetes genetic risk score. Participants (n = 2,751) were genotyped for 73 SNPs previously associated with type 2 diabetes, fasting glucose/insulin concentrations, obesity or lipid levels, from which five genetic risk scores (one for each of the
Microsoft Word - Slutrapport_Christel_redigerad av kund Research libraries and research data management within the humanities and social sciences MARIA JOHNSSON - JOHAN ÅHLFELDT | UNIVERSITY LIBRARY | LUND UNIVERSITY PROJECT REPORT 1 Research Libraries and Research Data Management within the Humanities and Social Sciences Project report Maria Johnsson and Johan Åhlfeldt University Library, Lund Un
https://www.ub.lu.se/en/sites/ub.lu.se.en/files/final_report_digital_humanities.pdf - 2026-07-01
Pedagogisk portfölj 0 . Pedagogisk portfölj Institutionen för service management och tjänstevetenskap vid Lunds universitet Malin Zillinger 2017-09-14 1 Introduktion Under 2016 slogs jag av den återkommande nyhetsrapporteringen om migrationen som verkade slå allt nya rekord i Europa. Det hela utvecklade sig till en yrkesrelaterad kris där jag undrade hur jag kan sitta på mitt kontor och rätta tent
https://www.sam.lu.se/internt/sites/sam.lu.se.internt/files/pedagigisk-portfolj-malin-zillinger.pdf - 2026-07-01
This study aims to examine how local governments originated from the global South, through Urban Food System Strategies (UFSS), are realizing global sustainability priorities as outlined by the Sustainable Development Goals (SDGs). This study is based on the policy analysis of three Latin American UFSS, with the aim to detect synergies and connections between the UFSS and the SDGs. The primary c
Aim: Negative Pressure Wound Therapy (NPWT) has become widely adopted over the last 15 years and over 1000 peer-reviewed publications are available describing its use. Despite this, there remains uncertainty regarding several aspects of usage. In order to respond to this gap a global expert panel was convened to develop evidence-based recommendations describing the use of NPWT. In this communicati
This report provides a summary of the third meeting of the Harmonising Outcome Measures for Eczema (HOME) initiative held in San Diego, CA, U.S.A., 6-7 April 2013 (HOME III). The meeting addressed the four domains that had previously been agreed should be measured in every eczema clinical trial: clinical signs, patient-reported symptoms, long-term control and quality of life. Formal presentations
Genetic risk scores (GRS), summing up the total effect of several single-nucleotide polymorphisms (SNPs) in genes associated with either coronary risk or cardiovascular risk factors, have been tested for association with ischemic stroke with conflicting results. Recently an association was found between a GRS based on 29 SNPs discovered by genome-wide association studies and hypertension. The aim
When biomass is used to produce fuels and green products by thermochemical conversion, the ability to handle or remove the fine particle phase in the product gas is crucial. The product gas from biomass gasification contains relatively volatile organic compounds (“tar”) condensed on nonvolatile cores of, for example, aggregated soot particles and char. The problems are, for example, that particles
In the development of new food products, more knowledge is needed about the occurrence and quantity of food-borne pathogens in the food chain to be able to implement effective control measures and assure food safety. In addition, improved understanding of how environmental factors and food preservatives effect the microbial virulence expression in foods will enable the formulation of new strategie
Popular Abstract in Swedish Populariteten av karttjänster, t.ex. på Internet, ökar ständigt. Detta beror till stor del på en hela tiden förbättrad teknik och ett ökande antal idéer för kartapplikationer. Exempel på kartapplikationer är: positioneringstjänster, navigationstjänster, och tjänster för att söka efter, titta på och ladda ner geografiska data och kartor. Kartorna i dessa tjänster skapas The research presented in this thesis has focused on methods for improving the legibility and usability of maps in real-time map services. The aim has been threefold: to create methods to increase the cartographic quality of maps in map services, to develop methods to measure the legibility, as perceived by the user, and to evaluate the quality of maps. Map services are becoming increasingly commo
The earlier studies in this measurement series defined the limits and aims for design process to create better ventilating helmets [1], and tested the insulation [2] and evaporative characteristics [3] of the designed mock-ups. In addition some of the tested mock-ups were modified to study more closely the factors that were expected to improve heat transfer from the bicycle helmets. The present pa
A statistical distribution for the number of CDMA RAKE fingers, N T, to be assigned in order to track a given percent of the total received power has been derived. The obtained distribution reveals a strong dependence of NT on the system bandwidth, the median RMS delay spread, its standard deviation and other environment specific parameters. Also, a statistical distribution for the fading width fw
Patients with an implantable cardioverter defibrillator (ICD) have in ongoing risk of sudden incapacitation that might cause harm to others while driving a car. Driving restrictions vary across different countries in Europe. The most recent recommendations for driving of ICD patients in Europe were published in 1997 and focused mainly oil patients implanted for secondary prevention. In recent year
The results of a search for pair production of the scalar partners of bottom quarks in 2: 05 fb(-1) of pp collisions at root s = 7 TeV using the ATLAS experiment are reported. Scalar bottom quarks are searched for in events with large missing transverse momentum and two jets in the final state, where both jets are identified as originating from a bottom quark. In an R-parity conserving minimal sup
