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Diagnostik av cancer avseende typ och ursprung är tillsammans med hur avancerad cancern är och om vissa särskilda tumöregenskaper föreligger de viktigaste faktorerna för val av behandling. Cancer diagnostiseras i de flesta fall med hjälp av mikroskop. Cancer i lunga kan vara svårdiagnostiserad då man ofta har tillgång till begränsad mängd vävnad från provtagning från tumören, och immunhistokemiska

Pancreatic Ductal Adenocarcinoma (PDAC) is a very aggressive disease, lacking effective therapeutic approaches and leaving PDAC patients with a poor prognosis. The life expectancy of PDAC patients has not experienced a significant change in the last few decades with a five-year survival rate of only 8%. To address this unmet need, novel pharmacological targets must be identified for clinical inter

Intravenous thrombolysis with tissue plasminogen activator is the only proven acute therapy for ischemic stroke. This therapy has not been translated into clinical practice in the developing world primarily due to economic constraints. Streptokinase, a lower cost alternative thrombolytic agent, is widely available in developing countries where it is utilized to treat patients with acute coronary s

Inherited retinal degenerations, collectively termed retinitis pigmentosa (RP), constitute one of the leading causes of blindness in the developed world. RP is at present untreatable and the underlying neurodegenerative mechanisms are unknown, even though the genetic causes are often established. Acetylation and deacetylation of histones, carried out by histone acetyltransferases (HATs) and histon

Mitochondrial creatine kinase (Mi-CK) isoenzymes, in contrast to cytosolic CKs, form octameric molecules composed of four stable dimers. Octamers and dimers are interconvertible. Removal of the N-terminal pentapeptide of chicken cardiac Mi-CK (Mib-CK) by limited proteolysis drastically destabilized the octamer. The role of the charged amino acids within the N-terminal heptapeptide was studied in d

Specialized epitope tags are widely used for detecting, manipulating or purifying proteins, but often their versatility is limited. Here, we introduce the ALFA-tag, a rationally designed epitope tag that serves a remarkably broad spectrum of applications in life sciences while outperforming established tags like the HA-, FLAG®- or myc-tag. The ALFA-tag forms a small and stable α-helix that is func

Lars Rönnstrand är forskargruppsledare för den här forskargruppenLars Rönnstrand is Research Group Leader for this research group

Hjärtinflammationsgruppen vid Lunds universitet undersöker immunologiska och inflammatoriska mekanismer som är involverade i hjärtsjukdomar. I djurmodeller utvecklar vi nya terapier riktade mot dessa mekanismer, som syftar till att minska hjärtskadan och förbättra hjärtfunktionen vid hjärtinfarkt, myokardit och septisk kardiomyopati. Vi bedriver också kliniska studier i stora patientkohorter för aThe Cardiac Inflammation Research Group at Lund University investigates immune and inflammatory mechanisms involved in cardiac disease. In animal models, we are developing novel therapies that target these mechanisms, aiming to reduce myocardial damage and improve cardiac function in myocardial infarction, myocarditis and septic cardiomyopathy. We are also performing clinical studies in large pati