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BACKGROUND: Elevated plasma levels of heparin-binding protein (HBP) are associated with risk of organ dysfunction and mortality in sepsis, but little is known about causality and mechanisms of action of HBP. The objective of the present study was to test the hypothesis that HBP is a key mediator of the increased endothelial permeability observed in sepsis and to test potential treatments that inhi

Infection with the human gastric pathogen Helicobacter pylori can give rise to chronic gastritis, peptic ulcer, and gastric cancer. All H. pylori strains express the surface-localized protein HpaA, a promising candidate for a vaccine against H. pylori infection. To study the physiological importance of HpaA, a mutation of the hpaA gene was introduced into a mouse-adapted H. pylori strain. To justi

The increased schizophrenia risks for residents of cities with high levels of competition and for members of disadvantaged groups (for example migrants from low- and middle-income countries, people with low IQ, hearing impairments or a history of abuse) suggest that social factors are important for aetiology, Dopaminergic dysfunctioning is a key mechanism in pathogenesis. This editorial is a selec

Halvledarindustrin har en form av immaterialrätter avsedd särskilt för dem: Kretsmönsterrätter. Dessa introducerades i USA 1984 i syfte att skydda den amerikanska halvledarindustrin från konkurrens från östra Asien, huvudsakligen Japan. Den ersatte principen om nationell behandling med den materiella ömsesidighetsprincipen, som är normen inom immaterialrätt. Detta tillät USA att tvinga andra ländeThe semiconductor industry has a sui generis IP type dedicated to it: the semiconductor topography right. This right was introduced in 1984 with the purpose of protecting the U.S. semiconductor industry from East Asian, mainly Japanese, competition. It replaced the principle of treatment on a national basis that is the norm in IP law with one of material reciprocity, which allowed the U.S. to stro

This research investigates global adoption and suitability of phased evacuation strategies in multi-purpose residential buildings, blending a review of 33 codes and standards in 11 nations with simulation-based analysis of 30 phased evacuation scenarios. Findings from the review reveal a varied level of importance of phased evacuation worldwide, with Europe, particularly the United Kingdom, showin

The performed study is a qualitative case study of the company Business Sweden. An inductive research approach has been used where we started by observing Business Sweden and subsequently applied suitable theories. The aim with the paper is to describe and analyze the aspects of management control in a multinational hybrid organization, by observing the process of centralizing the responsibility o

During 2011, ÅF launched a service called Green Business Screening (GBS) that provides a situation analysis of the overall environmental performance of a company. The model measures a company’s external and internal environmental integration and evaluates sustainability work through ten categories within a company, where the focus changes from internal categories to external categories. GBS is a g

Nowadays, the number of people infected with HIV/AIDS keeps rising in many countries. How can this risk be managed in society is an issue that gains on relevance. This paper focuses on the topic, how risk is communicated to society in the case of HIV/AIDS in Germany. It also looks at what aspects are emphasized and if different social groups are represented. Two nation-wide campaigns in Germany fr

Drowning is the second global leading cause of unintentional injury death for children ages 1 to 14 years, and the fifth leading cause for people of all ages (excluding flood disasters and water transport incidents). Why is the risk of drowning so high? It is important to investigate existing situation: what are the reasons that create a danger, is there a main risk group, how the risk of drownin

Type 1 diabetes is a complex disease characterized by the lack of endogenous insulin secreted from the pancreatic β-cells. Although β-cell targeted autoimmune processes and β-cell dysfunction are known to occur in type 1 diabetes, a complete understanding of the cell-to-cell interactions that support pancreatic function is still lacking. To characterize the pancreatic endocrine compartment, we stu

Local renin-angiotensin system (RAS) in female reproductive system is involved in many physiological and pathological processes, such as follicular development, ovarian angiogenesis, ovarian, and endometrial cancer progress. However, studies on the functional relevance of RAS in human endometrium are limited, especially for renin-angiotensin-aldosterone system (RAAS). In this study, we defined the

Neurons are continuously generated from stem cells in the hippocampus and along the lateral ventricles in the adult brain. Neural stem cells can be propagated in vitro in the presence of epidermal growth factor (EGF) or fibroblast growth factor-2. We report here that amphiregulin, a growth factor related to EGF, is a mitogen for adult mouse neural stem cells in vitro and displays potency similar t

Huntington's disease (HD) is a devastating, neurodegenerative condition, which lacks effective treatment. Normal Huntingtin (HTT) and mutant Huntingtin (mHTT) are expressed in multiple tissues and can alter transcription of microRNAs (miRs). Importantly, miRs are present in a bio-stable form in human peripheral blood plasma and have recently been shown to be useful biomarkers in other diseases. We