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Background: Clinical tools to diagnose the early changes of osteoarthritis (OA) that occur in the articular cartilage are lacking. Objectives: We sought to identify and quantify a novel cartilage oligomeric matrix protein (COMP) neoepitope in the synovial fluid from the joints of healthy horses and those with different stages of OA. Study design: In vitro quantitative proteomics and assay developm
A search is conducted for hadronic three-body decays of a new massive coloured particle in root s = 7 TeV p p collisions at the LHC using an integrated luminosity of 4.6 fb(-1) collected by the ATLAS detector. Supersymmetric gluino pair production in the context of a model with R-parity violation is used as a benchmark scenario. The analysis is divided into two search channels, each optimised sepa
Background Leaf-cutting ants live in symbiosis with a fungus that they rear for food by providing it with live plant material. Until recently the fungus' main inferred function was to make otherwise inaccessible cell wall degradation products available to the ants, but new studies have shed doubt on this idea. To provide evidence for the cell wall degrading capacity of the attine ant symbiont, we
This Letter presents the results of a direct search with the ATLAS detector at the LHC for a Standard Model Higgs boson of mass 110 <= m(H) <= 130 GeV produced in association with a W or Z boson and decaying to b (b) over bar. Three decay channels are considered: ZH -> l(+)l(-)b (b) over bar, WH -> lvbb (b) over bar and ZH -> v (v) over bar(b) over bar where l corresponds to an electron or a muon.
The Amazon has always been a strategic region because of its rich variety in natural resources. Its global interest is spreading across levels and scales, influenced by the increasing demand for fossil fuels and biodiesel and the threat of climate change. Neoliberal practices continue privatizing and exploiting the Amazon´s resources regardless the Indigenous communities’ interests. These communit
Behavior and social interactions are key features to determine the phenotype of an organism. Observing behavioral manifestations give insides on a fundamental level of how inner mechanisms work. But how is it possible to predict behavior in a way, such that it can be quantify and analyzed? One traditional strategy is to annotate the behavior by hand. Observing the animals and making notes about th
In a changing world order, emerging middle powers from the global South may seek new positions in international societies. Using the United Nations as an international society, this thesis aims to investigate what roles the emerging middle powers, Brazil and South Africa, enact in pursuing permanent seats at the Security Council. This research conducts a qualitative text analysis using official da
Humanitarian crises are becoming more frequent- and increasingly protracted, causing humanitarian actors to be under mounting pressure in their attempts to respond to the increasing amount of people in need. Among else, cash-based programming has been highlighted as part of the solution to this and has been rapidly on the rise as an aid modality among humanitarian actors in the past few years. Whi
The aim of the present study was to evaluate the risk for vascular morbidity or death and retinopathy in relation to urinary albumin concentration. To that end, we performed a 5-year follow-up study of all type 2 diabetic patients attending the outpatient-clinic. A total of 444 (98.4%) out of 451 adult patients initially studied were evaluated for the degree of retinopathy and levels of HbA1c bloo
Background: Small bowel neuroendocrine tumours often present with locally advanced or metastatic disease. The aim of this paper is to provide evidence-based recommendations regarding (controversial) topics in the surgical management of advanced small bowel neuroendocrine tumours. Methods: A working group of experts was formed by the European Society of Endocrine Surgeons. The group addressed 11 cl
Background: Retention of study participants in observational studies is essential to maintaining the representativeness of the population, minimizing selection bias, and assuring sufficient statistical power. The aim of this report is to describe the structures and strategies used to retain participants in The Environmental Determinants of Diabetes in the Young (TEDDY) Study, an observational stud
Abstract is not available
The aims were to study the biological, socio-demographic and psychosocial health profile in a geographically defined population of middle-aged women, with focus on features of the metabolic syndrome and diabetes, and to study the efficiency of a screening method for high-risk individuals and the outcome of baseline lifestyle advices on the diabetes incidence. All women aged 50-59 years (n=10766)
Inversion recovery (T-1) and microwave power saturation studies have been performed, between 4 and 25 K, on the EPR signal from the stable tyrosyl radical, Y-D(.), in photosystem II core complex preparations from higher plants. Measurements are reported from the dark stable S-1 and first turnover S-2 states of the photosystem catalytic Mn cluster and in two cryoprotectant regimes; sucrose and ethy
The responses to step and pulse transients with reactants have been simulated for conventional step-transient conditions at atmospheric pressure and pulsing under vacuum using a temporal analysis of products (TAP) reactor, respectively. Propene oxidation over an oxide catalyst with the participation of lattice oxygen was chosen as a model reaction. The mechanism comprises adsorption of the reactan
Using two epochs of HST/WFPC2 images of the metal-rich globular clusterNGC 6528 we derive the proper motions of the stars and use them toseparate the stars belonging to NGC 6528 from those of the Galacticbulge. The stellar sequences in the resulting colour-magnitude diagramfor the cluster are significantly better determined than in previouslypublished data. From comparison of the colour-magnitude
The lower electronic states of the molecule PbO have been studied using a newly developed basis set of the atomic natural orbital (ANO) type. The method includes scalar relativistic effects through the use of a Douglas-Kroll Hamiltonian. Multiconfigurational wave functions have been used with dynamic correlation included using second-order perturbation theory (CASSCF/CASPT2). Spin-orbit coupling i
