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Gruppens huvudsakliga forskningsområde är systemisk behandling av spridd cancersjukdom med hjälp av terapeutiska radionuklider. För att optimera dosleveransen till tumörceller konjugeras radionukliderna till målsökande molekyler, t.ex. antikroppar, som söker sig till cancerspecifika antigen. Olika behandlingsstrategier utvärderas prekliniskt för bästa effektivitet. Multimodala bildgivande system The main research area of the group is systemic treatment of metastasized cancer using therapeutic radionuclides. To optimize dose delivery to tumor cells, radionuclides are conjugated to tracer molecules, e.g. antibodies or antibody fragments, targeting cancer-specific epitopes. Preclinical evaluation of treatment combinations and strategies aim to improve treatment efficacy. Multimodality imagin

Stefan Karlsson är forskargruppsledare för forskargruppenStefan Karlsson is Research Group Leader for this research group

This project aims to develop incretin therapy as a glucose-reducing strategy in type 2 diabetes (T2D). Its particular focus is to understand the mechanisms of incretin therapy and to optimize its clinical positioning. This mission is achieved by an interdisciplinary approach with complementary studies in subjects with T2D, healthy volunteers and experimental animals.

Internet services can aid steps towards sustainability, but can also be a means of exploitation and power-ownership. Data centres are an intrinsic part of this system, but reporting regulations do not require full disclosure on them. This paper takes the position that incomplete or misleading reporting is a form of delay discourse. Using the case study of Spotify, a structured literature review wa

OBJECTIVE: To deepen the knowledge of frail elderly patients' preferences for participation in medical decision making during hospitalization.METHODS: Qualitative study using content analysis of semi-structured interviews.RESULTS: Patient participation to frail elderly means information, not the wish to take part in decisions about their medical treatments. They view the hospital care system as an

The calcium-releasing second messenger inositol 1,4,5-trisphosphate is involved in the regulation of stomatal aperture by ABA. In other signalling pathways, inositol 1,4,5-trisphosphate is generated by the action of phospholipase C. We have studied the importance of phospholipase C in guard cell ABA-signalling pathways. Immunolocalisation of a calcium-activated phospholipase C confirmed the presen

miRNAs are involved in the tumorigenesis of various malignancies. In the current study, we found that miR-194-5p expression is downregulated in ovarian cancer tissues, and downregulation of miR-194-5p expression promotes proliferation, invasion and migration of human ovarian cancer cells in vitro and ovarian tumor growth in nude mice. We further found that IGF1R and PPFIBP are targets of miR-194-5