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The study of clines, or geographical variations of a given trait, can help understand how the interactions of genetics and local environments determine phenotypic diversity. The marine snail Littorina saxatilis (Olivi, 1792) exhibits a gradual change in the relative frequencies of shell color morphs across populations in the estuary system of the Rias Baixas (Galicia, NW Iberian Peninsula). A cons
Enzymes play a key role in almost all biological processes, accelerating a variety of metabolic reactions as well as controlling energy transduction, the transcription, and translation of genetic information, and signaling. They possess the remarkable capacity to accelerate reactions by many orders of magnitude compared to their uncatalyzed counterparts, making feasible crucial processes that woul
This paper examines the assumption that the volume of domestic patenting in Vietnam is too low and needs to be expanded. The structure and state of development of the Vietnamese economy and a set of relevant systems - including the Science and Technology (S&T) System, the Intellectual Property System, the National Innovation System (NIS), and the Science, Technology and Innovation (STI) Policy
This paper is based on a study where four go-along interviews with a total of sixteen participants were conducted in three Swedish cities. The purpose of this study was to find out how different aspects and qualities of the built environment affected different persons in terms of experiences of inclusion and exclusion and strategies used to deal with obstacles in the environment. The study highlig
Artificial Intelligence in Cardiothoracic Science was funded 2006. Traditionally, medical decisions are based on the combined strength of clinical facts and the experience of the clinician. A growing understanding of the molecular, genetic and biochemical basis of diseases have greatly increased the degree of complexity in medical decision-making. To identify risk factors in medical registers, a nArtificial Intelligence in Cardiothoracic Science was funded 2006. Traditionally, medical decisions are based on the combined strength of clinical facts and the experience of the clinician. A growing understanding of the molecular, genetic and biochemical basis of diseases have greatly increased the degree of complexity in medical decision-making. To identify risk factors in medical registers, a n
Background & Aims: Glucagon-like peptide-2 (GLP-2) is a 33-amino acid peptide hormone secreted by enteroendocrine cells in response to nutrient ingestion. GLP-2 stimulates crypt cell proliferation leading to expansion of the mucosal epithelium; however, the mechanisms transducing the trophic effects of GLP-2 are incompletely understood. Methods: We examined the gene expression profiles and gro
A key step in lipolytic activation of adipocytes is the translocation of hormone-sensitive lipase (HSL) from the cytosol to the surface of the lipid storage droplet. Adipocytes from perilipin-null animals have an elevated basal rate of lipolysis compared with adipocytes from Wild-type mice, but fail to respond maximally to lipolytic stimuli. This defect is downstream of the p-adrenergic receptor-a
elwood is the main source of cooking and heating energy for households in rural sub-Saharan Africa. Unfortunately, most of these households use inefficient biomass cook stoves, leading to consumption of more fuel and exposure to indoor air pollutants and associate health problems which disproportionately affect women and children. However, adoption of cleaner biomass cook stoves has remained low w
Traumatisk hjärnskada (THS) är en vanlig orsak till död och kvarstående handikapp och idag saknas effektiva behandlingar. Vår forskargrupp använder experimentella och kliniska tekniker att studera THS, från de allra svåraste skadorna till de mer milda skadorna som kan ses exempelvis efter hjärnskakning inom idrotten. Hjärnans egen förmåga till läkning är begränsad efter THS och ett viktig mål för Traumatic brain injury (TBI) is a common cause of death and disabilities and current treatment options are limited. The research group uses experimental and clinical approaches to study TBI, from the most severe brain injuries to the milder sport-related concussions. The brain´s own capacity for repair is poor and one research aim is to enhance brain recovery and repair following injury. TBI is al
Objective:To examine the impact of non-response to self-reported body weight and height in health questionnaires for the estimation of obesity prevalence.Methods and Procedures:A cross-sectional population-based health survey in the community ofVara with 16,009 residents (in year 2002) in South-western Sweden. Participants randomly selected in strata by sex and age among residents being 30-74 year
Vår forskning handlar om att kartlägga de mekanismer som ligger bakom njursjukdom för att ta fram ny diagnostik och behandling för de cirka 10% av Sveriges befolkning som lider av nedsatt njurfunktion. Vi forskar också fram nya metoder för att förbättra behandlingen med så kallad peritonealdialys (bukdialys) - en form av dialysbehandling för patienter med svår njursvikt. Vi samarbetar med andra foOur research focuses on identifying the mechanisms behind kidney disease in order to develop new diagnostic methods and treatment for the approximately 10% of Sweden's population suffering from impaired renal function. We are also researching new methods to improve treatment with peritoneal dialysis - a form of dialysis treatment for patients with severe renal failure. We collaborate with other re
Popular Abstract in Swedish Uppskattningsvis 140–180 000 patienter i Sverige har förmaksflimmer. Den totala förekomsten är dock okänd eftersom vissa patienter också helt saknar symtom och därför inte har kännedom om sin sjukdom. Förmaksflimmer, som både kan vara kroniskt eller komma i attacker, innebär att förmaken inte aktivt pumpar ner blodet i hjärtats kammare. Istället sker mer okoordinerade sBackground: Oral antigoagulation treatment (OAT) with warfarin have a narrow therapeutic window and patients exhibit a highly variable doseresponse that is attributable to genetic, disease-related,and environmental factors as well as prescription and nonprescription drugs, dietary vitamin K and alcohol. The effect of warfarin treatement on blood coagulation is measured using international normaliz
Vårt mål är att öka kunskapen om demens- och minnessjukdomar - alltifrån uppkomst till behandling. Forskningen omfattar ett flertal diagnoser, bland annat Alzheimers sjukdom, Lewy Body demens och Parkinsons sjukdom. Markörer och tidig upptäckt av Alzheimer, genom bland annat ryggvätskeprov, är ett styrkeområde där vi uppnått resultat som omsatts i daglig, klinisk användning. Genom innovativ använWe embrace the big picture of dementia and memory diseases. This includes the course from origin and early detection to treatment. The scope includes a wide range of diagnoses, among these Alzheimer’s Disease, Lewy Body Dementia and Parkinson’s Disease. Early detection of Alzheimer’s Disease, by using new markers, is one of our most promising fields. Spinal fluid test concepts, developed by us, ar
Mjukdelssarkom utgör en heterogen grupp av ovanliga tumörer och innefattar ett 50-tal olika subtyper med varierande klinisk bild och prognos. Två tredjedelar är höggradigt maligna tumörer och en tredjedel av patienterna avlider i tumörsjukdom. I Södra sjukvårdsregion är vården av patienter med sarkom centraliserad till SUS/Lund. Sarkomgruppen i Lund utreder och behandlar patienter med sarkom och Soft tissue sarcomas constitute a heterogeneous group of rare tumours with some 50 histopathologic types with different clinical characteristics and prognosis. Two thirds are highly malignant tumours and one third of the patients die due to metastatic disease. The care of sarcoma patients in the Southern Swedish health care region is centralised to the Lund Sarcoma Centre. We have a large data ba
