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Resistance to the HER-2 targeting drug trastuzumab can be observed clinically, but the lack of suitable experimental models hampers studies of resistance mechanisms. We characterized a HER-2–positive carcinoma cell line (JIMT-1) derived from a 62-year-old breast cancer patient which was clinically resistant to trastuzumab. Multicolor fluorescence in situ hybridization revealed a complex hyperdiplo
Premixed turbulent flame-based technologies are rapidly growing in importance, with applications to modern clean combustion devices for both power generation and aeropropulsion. However, the gain in decreasing harmful emissions might be canceled by rising combustion instabilities. Unwanted unsteady flame phenomena that might even destroy the whole device have been widely reported and are subject t
Background. The objective was to determine how postmenopausal bleeding (PMB) is managed in Sweden today, and to relate the findings to a new evidence-based algorithm for the management of PMB. Methods. A questionnaire regarding the role of ultrasound and the use of different endometrial biopsy methods in the management of PMB was sent to all 61 gynecologic departments in Sweden. Results. Fifty-n
This study aimed to compare the duration of protection against exercise-induced bronchoconstriction (EIB) after inhalation of formoterol (Oxis) Turbuhaler with that of terbutaline Turbuhaler and placebo Turbuhaler in asthmatic patients treated regularly with formoterol Turbuhaler 9 microg b.i.d. and inhaled steroids. The study. performed at three centres (Goteborg and Lund, Sweden, and Trondheim,
We screened 150 olfactory sensilla in single-sensillum recordings to unravel the mechanisms underlying host selection in the spruce bark beetle, Ips typographus (Coleoptera: Curculionidae: Scolytinae). Odor stimuli comprised of pheromone (various bark beetle spp.), host, and non-host compounds elicited strong and selective responses from 106 olfactory receptor neurons (ORNs), 45 of which were tune
Prior to the accomplishment of this research, the compatibility of the classic e-servicescape conceptual model in the context Taobao and TMall in China were rarely found among existing e-servicescape literatures due to the standardization taken by both online platforms towards the establishment of individual webshops. Meanwhile, the conceptualization of social factors as social dimension of e-serv
The purpose of this report is to build on the knowledge of how parties facing poor election results make changes in their election manifesto. The case in question is the Swedish party Liberalerna, in English referred to as The Liberals. The empirical data that is used is two of the parties election manifestos from 2014 together with 2018. These are coded by Manifesto Project Database. Using three
This thesis describes attempts at estimating the uncertainty of the 2-metre temperature forecast error from a probabilistic point of view, utilizing Bayesian neural networks. Bayesian neural networks are a type of machine-learning algorithms used to find patterns in data and make probabilistic predictions. Multiple fields of output data from the ECMWF IFS global model, along with temperature measu
I svensk inkomstskatterätt är huvudregeln att ett underskott i inkomstslaget näringsverksamhet som kvarstår från föregående år ska dras av. Denna huvudregel motiveras av att ett strikt upprätthållande av principen om beskattningsårets slutenhet innebär att skattesubjekt vars inkomster i stor utsträckning varierar från beskattningsår till beskattningsår riskerar att beskattas hårdare än skattesubjeThe general rule in Swedish tax law stipulates that net operating losses incurred by a company for one taxable year are to be carried-forward and offset against future profits. This is considered a deviation from the general principle of separate annual tax accounting. The deviation is done with regards to the fact that a tax entity whose income is subject to drastic changes over the years might b
In this essay I’ll be doing a Crip Reading of two Swedish young adult novels, Här ligger jag och blöder and Jag är ju så jävla easy going. By using Crip Theory and “Skevteori”, I examine how disabilities are constructed and performed within the text, as well as how it's talked about and viewed among the novels’ characters. I also examine how disabilities interact with gender and how some sympt
Offentlig upphandling handlar om hur den offentliga sektorn ska agera vid inköp och har därmed en betydande påverkan på samhällsekonomin. Essentiella samhällsfunktioner som exempelvis sjukvård och skolor tillgodoses genom offentlig upphandling. Eftersom inköpen görs via skattemedel har samhällsmedborgare ett intresse av att förfarandet går rätt till. Vidare har leverantörer ett intresse av att förPublic procurement concerns how the public sector should act when making purchases and therefore has a great impact on the national economy. Fundamental societal functions such as healthcare and education are supported through public procurement. Because these purchases are made using tax revenue, citizens have an interest in ensuring that the procedure is conducted properly. Moreover, suppliers h
Sammanfattningsvis kan om bestämmelserna i tysk och svensk rätt sägas att de är tämligen lika varandra i rekvisiten och deras utläggning, dock med skillnaden att de tyska rekvisiten tycks tolkas striktare. Därmed slutar de huvudsakliga likheterna, och de många skillnaderna tar vid. Inget av den tyska rättens två brott (Verleumdung och üble Nachrede) motsvarar direkt det svenska förtalsbrottet, ochIn summary, it can be said about the provisions in German and Swedish law that they are fairly similar in terms of the necessary prerequisites and their interpretation, although with the difference that the German prerequi-sites seem to be interpreted more strictly. Thus end the main similarities, and the many differences begin. Neither of the two crimes under German law (Verleumdung and üble Nach
The purpose of the essay is to study the influence given to doctors in the regulations about forensic psychiatry examinations. The essay compares the regulations and the current ideas that did exist during the regulations application. Thereafter the alterations in the influence will be presented and what impact the current ideas may have had. The charter from year 1826 demanded the court to obta
För att dömas till straffansvar enligt svensk rätt krävs att gärningspersonen uppvisar skuld antingen i form av uppsåt eller oaktsamhet. Straffrättsligt ansvar för våldtäkt förutsätter enligt svensk rätt att gärningspersonen begår gärningen med uppsåt. I våldtäktsbrottmål kan en gärningsperson som misstar sig om en relevant omständighet och alltså begår gärningen utan uppsåt inte dömas till straffTo be held liable for a crime under Swedish law, the offender has to show guilt, either intentionally or through negligence. According to Swedish law, criminal liability for rape presupposes that the perpetrator has committed the act intentionally. In rape crime cases, an offender cannot be convicted if he or she is mistaken about a relevant circumstance and hence commits the act through negligenc
Tetra Pak is the world’s largest producer of beverage cartons with an annual worldwide production of about 150 billion packages. They work actively with improving their recycling efficiency by setting recycling rate goals for the next three, six and nine years for each market. These goals have so far been educated guesses and there is a need for investigating what drives and predicts recycling eff
Populärvetenskaplig sammanfattning: Hjälper Nhandugue-flodens vatten Urema-sjön i Gorongosa Nationalpark, Moçambique, från att torka ut? I de centrala delarna av Moçambique ligger Gorongosa Nationalpark som skyddar ett omfattande ekosystem av flodplan, gräsmarker och skogsbeklädda områden. Efter drygt 20 år av inbördeskrig hade 1994 antalet stora däggdjur, så som lejon, zebror och bufflar, minskatGorongosa National Park in central Mozambique is situated at the southernmost extension of the East African Rift System (EARS), the Urema Rift. The park is protecting a vast ecosystem of floodplains, grasslands and woody coverage. From 20 years of civil war the large-mammal population in the park had in year 1994 been reduced by 90 % or more, and in 2004 a restoration project was started in order
Syftet med denna uppsats är att redogöra för hur fenomenet tiggeri har hanterats i svensk, dansk och norsk lagstiftning över tid, med betoning på 1800-talet fram till idag. Uppsatsen vill också svara på om gällande lagstiftning är problematisk och om den därför är på väg att ändras. Tiggeri är ett fenomen som idag sammankopplas med sociala problem som exempelvis fattigdom. Faktorer som har inverThe aim for this essay is to investigate how begging has been regulated in Swedish, Danish and Norwegian legislation during history, in particular from the 19th century until today. The essay’s aim is also to investigate if there are problems with the current regulations and if they are about to be changed. Begging is a term associated with social problems as poverty. Variables, which have influe
