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Study objectives: The aim of this study was to develop quality criteria for further development and use in the Medicines Management(MM) process in European hospitals. Methods: Criteria for MM were developed in three steps using a modified two-stage Delphi-technique. In the first step a literature search was performed and 300 topics were listed. These topics were grouped into three dimensions, e
Abstract The present thesis explored the epidemiology of intracerebral haemorrhage (ICH), i.e., factors associated to incidence and prognosis. In the population of Malmö (Malmö 1990 cohort), it was shown that immigrants from China/Vietnam and the Former Soviet Union had higher risk of ICH than citizens born in Sweden. Although hypertension is a well-known risk factor for stroke, the relation
Background: The thorough assessment of familial prostate cancer (PCa) risk is as important as ever to provide a basis for clinical counselling and screening recommendations. Objective: Our aim was to determine the age-specific risks of PCa and the risk of death from PCa according to the number and the age of affected first-degree relatives. Design, setting, and participants: The nationwide Swedish
Objective To determine whether environmental control using nocturnal temperature controlled laminar airflow (TLA) treatment could improve the quality of life of patients with persistent atopic asthma. Design Randomised, double-blind, placebo-controlled, parallel-group trial. Setting Nineteen European asthma clinics. Participants 312 patients aged 7-70 with inadequately controlled persistent atopic
Background: The humerus is the second most common long-bone site of metastatic bone disease. We report complications, risk factors for failure, and survival of a large series of patients operated on for skeletal metastases of the humerus. Materials and methods: This study was based on 208 patients treated surgically for 214 metastatic lesions of the humerus. Reconstructions were achieved by intram
We present the first continuous paleolimnological reconstruction from the North Island of New Zealand (37A degrees S) that spans the last 48.2 cal kyr. A tephra- and radiocarbon-based chronology was developed to infer the timing of marked paleolimnological changes in Lake Pupuke, Auckland, New Zealand, identified using sedimentology, magnetic susceptibility, grain size and geochemistry (carbon, ni
Objectives. To study mortality rates among men and women with atrial fibrillation (AF) and concomitant chronic heart failure (CHF) prescribed different classes of cardiovascular drugs in primary health care. Design. A cohort of men (n = 1159) and women (n = 1155) aged 45 years or above and diagnosed with both AF and CHF from patient records from 75 primary care centers in Sweden were included in t
The incidence of colorectal cancer (CRC) in young patients (≤50 years of age) appears to be increasing. However, their clinicopathological characteristics and survival are controversial. Likewise, the biomarkers are unclear. We used the West China (2008-2013, China), Surveillance, Epidemiology, and End Results program (1973-2011, United States) and Linköping Cancer (1972-2009, Sweden) databases to
Introduction A recent genome-wide association study in European systemic sclerosis (SSc) patients identified three loci (PSORS1C1, TNIP1 and RHOB) as novel genetic risk factors for the disease. The aim of this study was to replicate the previously mentioned findings in a large multicentre independent SSc cohort of Caucasian ancestry. Methods 4389 SSc patients and 7611 healthy controls from differe
Hyaluronan is an unsulfated linear glycosaminoglycan with the ability to nucleate extracellular matrices by the formation of aggregates with lecticans. These matrices are essential during development of the central nervous system. In the prospective white matter of the developing brain hyaluronan is organized into fiber-like structures according to confocal microscopy of fixed slices which may gui
Climate change is an issue affecting societies worldwide. As temperatures, precipitation patterns, and sea levels change, our buildings and properties are in danger. Therefore, it is crucial for real estate companies to adapt their properties to the effects of climate change as they will be impacted. To help companies make environmentally sustainable economic activities, the European Union has imp
The purpose of this study is to investigate how women with an ADHD diagnosis, who were diagnosed in the ages between 12-17, see their own experiences and identities in relation to role expectations of females. The ambition is to bring light to the stories of women, who have been in the shadow of the stereotypical ADHD man in society as well as in studies. The method chosen for empirical material i
Helicobacter pylori is an important pathogen inhabiting the human stomach. H. pylori binds plasminogen, a 90 kDa glycoprotein secreted by liver cells, and utilizes it for enhancing virulence. Surface receptors on the bacteria recognize plasminogen that is then activated into plasmin by host factors. The active plasmin can degrade a range of host proteins including proteins of the extracellular mat
Popular science summary Identifying an African Paradise Flycatcher using molecular techniques Five species of Paradise Flycatchers (Terpsiphone) occur in mainland Africa. Colour polymorphism and hybridization in these birds make species identification and defining species boundaries challenging. A melanistic individual was captured in Gashaka-Gumti National Park in Nigeria, and could not be iden
Popular science General introduction Two main activities take place into forests: photosynthesis, or GPP (the uptake of CO2 by plants, which leads to their growth) and respiration (the release of CO2 by those plants). The Net Ecosystem Exchange NEE is the difference between photosynthesis and respiration, and it depends on the nature of the forests and on climate particularities. With the ongoing This study shows how six different European forests react during the summer to abnormally warm temperatures, from 1996 to 2006. With the forecasted increase of summer temperatures over Europe, the carbon balance of forests – photosynthesis (GPP), ecosystem respiration and Net Ecosystem Exchange - in likely to change. In this thesis, the photosynthesis and the respiration of six European forests w
Pekskärmar är en typ av inmatningsenhet som möjliggör en interaktion mellan en användare och en elektronisk enhet. Interaktionen sker genom att låta användaren röra med en eller flera fingrar eller en stylus-penna på skärmen. Pekskärmar används idag till en rad olika elektroniska produkter som till exempel mobiltelefoner, surfplattor, datorer och även bankomater. På grund av sitt breda användningsTouchscreens are a type of input device that facilitate interaction between a user and an electronic device. This interaction is enabled by the user touching the screen with one or more fingers or a stylus pen. Today, touchscreens are implemented in a wide range of electronic products for example mobile phones, tablets, computers, and even ATMs. Due to their wide range of applications, touchscreen
Flood risk is influenced not only by climate change but also underlying factors including unplanned urbanization, environmental degradation, poverty, social inequalities and weak governance. Given its complexity, effective flood risk management requires a better understanding of its conceptual context and comprehensive assessments that beyond hazard consider exposure, vulnerability and capacity. T
