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The endogenous reparative capacity of the adult human brain is low, and chronic neurodegenerative disorders of the central nervous system represent one of the greatest areas of unmet clinical need in the developing world. Novel therapeutic strategies to treat them include: (i) growth factor delivery to boost endogenous repair and (ii) replacement cell therapy, including replacing dopaminergic neur

Abstract Background: Osteoarthritis (OA) is the most common joint disorder globally and a major cause of disabiltiy with the knee joint responsible for 80% of the disease burden. Progressive degenerative changes in cartilage tissue result in deterioration and loss of articular cartilage. Cartilage has poor capacity of healing and the detection of degeneration usually occurs at a stage of progressiAbstract Background: Osteoarthritis (OA) is the most common joint disorder globally and a major cause of disabiltiy with the knee joint responsible for 80% of the disease burden. Progressive degenerative changes in cartilage tissue result in deterioration and loss of articular cartilage. Cartilage has poor capacity of healing and the detection of degeneration usually occurs at a stage of progressi

Presentation of a protein antigen to T cells generally requires that the antigen be enzymatically processed into an immunogenic peptide(s). The identification of a protease(s) and its mechanism of action in the proteolysis of such an antigen is therefore a primary goal in the study of antigen processing. We show here that Insulin degrading enzyme (IDE), a neutral thiol metalloendo-proteinase that

Implicit assumptions, approaches, rules and practices in teaching i.e. teaching and learning regimes (TLRs) are produced and reproduced (cf. Trowler & Cooper 2002) in the closest teaching environment, traditionally within a discipline. However, multidisciplinary programs implies that teachers from different disciplines and with different taken for granted assumptions, approaches and rules are Implicit assumptions, approaches, rules and practices in teaching i.e. teaching and learning regimes (TLRs) are produced and reproduced (cf. Trowler & Cooper 2002) in the closest teaching environment, traditionally within a discipline. However, multidisciplinary programs implies that teachers from different disciplines and with different taken for granted assumptions, approaches and rules are

Should an inflation-targeting central bank have an explicit tolerance band around its inflation target? This paper provides an answer derived from the Swedish experience. The Riksbank is exceptional in the sense that it first adopted and later abolished an explicit band and is currently considering bringing it back. We conclude that the band should be explicit for several reasons. Most important, Should an inflation-targeting central bank have an explicit tolerance band around its inflation target? This paper provides an answer derived from the Swedish experience. The Riksbank is exceptional in the sense that it first adopted and later abolished an explicit band and is currently considering bringing it back. We conclude that the band should be explicit for several reasons. Most important,

The emancipatory appropriation of space, in the sense making personal adjustments and manoeuvres in order to raise a sense of space, can be understood in terms of giving and taking form, or what Catherine Malabou calls “plasticity”. Spatial production is in this sense defined relationally and cannot be fully provided by programmed architectural functions. That kind of relational and emancipatory vThe emancipatory appropriation of space, in the sense making personal adjustments and manoeuvres in order to raise a sense of space, can be understood in terms of giving and taking form, or what Catherine Malabou calls “plasticity”. Spatial production is in this sense defined relationally and cannot be fully provided by programmed architectural functions. That kind of relational and emancipatory v

This thesis concerns the law/fact distinction in law. The interest it takes in the distinction is not practical, but conceptual. It more specifically concerns the questions: “What is it that is conceptually assumed about something when it is categorized as ‘of law’ or ‘of fact’?” and “What is conceptually assumed about the law when law is distinguished from fact by the use of the law/fact distinctThis thesis concerns the law/fact distinction in law. The interest it takes in the distinction is not practical, but conceptual. It more specifically concerns the questions: “What is it that is conceptually assumed about something when it is categorized as ‘of law’ or ‘of fact’?” and “What is conceptually assumed about the law when law is distinguished from fact by the use of the law/fact distinct

Researchers and teachers often recommend motivating exercises and use of mathematics or statistics software for the teaching of basic courses in probability and statistics. Our courses are given to large groups of engineering students at Lund Institute of Technology. We found that the mere existence of real-life data and technology in a course does not automatically increase students’ motivation o

Ecological impacts of urbanization include the loss of biodiversity and changes in species composition and population densities. However, how the urban environment affects fundamental physiological parameters is largely unknown. Here, we investigated physiological components related to health and nutrition, namely, plasma fatty acids (FA) and lipid peroxidation at inter-habitat and interspecific lEcological impacts of urbanization include the loss of biodiversity and changes in species composition and population densities. However, how the urban environment affects fundamental physiological parameters is largely unknown. Here, we investigated physiological components related to health and nutrition, namely, plasma fatty acids (FA) and lipid peroxidation at inter-habitat and interspecific l

Several extensions of the standard model predict associated production of dark-matter particles with a Higgs boson. Such processes are searched for in final states with missing transverse momentum and a Higgs boson decaying to a bb pair with the ATLAS detector using 36.1 fb-1 of pp collisions at a center-of-mass energy of 13 TeV at the LHC. The observed data are in agreement with the standard mode

För att kunna jämföra värdering av onoterade bolag med marknadsvärden värderas 38 st bolag strax efter att de noterats. Vi antar att värdering strax efter notering är en god approximation av värden för bolag strax före notering. Relativ värdering med P/E-, P/B- och P/S-multiplarna används för bolag i fastighets- och läkemedelsbranschen. Vid värdering av fastighetsbolag med P/B-multipeln är det sta

I detta examensarbete analyseras och diskuteras de omfattande förändringar inom rättsområdet grundläggande rättigheter som följt efter att Lissabonfördraget trädde i kraft den 1 december 2009. Arbetet är avgränsat till att beskriva de förändringar som art. 6.1 och art. 6.2 i Fördraget om Europeiska Unionen (FEU) inneburit. Enligt art. 6.1 ska den Europeiska Unionens Stadga om de Grundläggande RättThis thesis analyses and discusses some of the substantial changes brought about for the field of fundamental rights by virtue of the entry into force of the Lisbon Treaty 1 December 2009; Art. 6(1) to the Treaty on European Union (TEU), according to which the Charter of Fundamental Rights of the European Union (CFREU) “shall have the same legal value as the Treaties” and Art. 6(2) TEU according t

According to the 1951 Refugee Convention, it is the state’s responsibility to protect and provide basic services to the refugees within their border. However, even if ratified to the Convention, it is common that the state decides to relinquish its responsibilities for various reasons. In Trinidad and Tobago, no national refugee policy has been adopted since the ratification of the 1951 Refugee Co

We present a model for developing health services for men who have sex with men (MSM) in sub-Saharan Africa and other places where MSM are heavily stigmatized and marginalized. The processes of the SPEND model include Safe treatment for sexually transmissible infections (STIs) and HIV; Pharmacy sites for treatment of STIs in countries where pharmacies and drug stores are the source of medical advi

Corporate Social Responsibility (CSR), ofta översatt till svenska som företagens samhällsansvar, är något som diskuterats flitigt under de senaste åren. Utvecklingen av CSR har dock pågått sedan 1950-talet och fortsätter att utvecklas än idag. Majoriteten av denna utveckling har skett inom den ekonomiska vetenskapen och inom ramen för företagens arbete med CSR. Det är först under de senaste 20 åreCorporate Social Responsibility (CSR) is something that has been discussed heavily in recent years. The development of CSR has been evolving since the 1950s and continues to evolve today. The majority of this development has taken place in economic science and within the framework of the companies work with CSR. It is only in the last 20 years that lawyers have seriously interested themselves in t

Uppsatsen handlar om internprissättning, som är prissättning av gränsöverskridande transaktioner mellan företag i intressegemenskap och är idag viktigt ämne inom skatterätt. Det har kommit att bli en av de viktigaste skattefrågor för multinationella företag och skattemyndigheter världen över. I uppsatsen presenteras läsaren för internprissättning som ämne och därefter beskrivs den rättsliga reglerThis paper deals with transfer pricing, which is the pricing of cross-border transaction between related persons and is today an important issue in tax Law. It has become one of the most important issues for multinational companies and tax authorities across the world. In this paper the reader will be introduced to transfer pricing as an issue followed by a description of the relevant regulation w

Title: Knowledge acquisition for a new business model creation and enabling factors Date of the seminar: 28-05-2015 Course: Master Corporate Entrepreneurship and Innovation Internship and Degree Project (Master Thesis 15 ECTS) Authors: Dovilė Gedvilaitė and Shubhabrata Paul Supervisor: Dr. Joakim Winborg Keywords: business model innovation, change, creation, knowledge, knowledge acquisition