Filetype
Endocrine resistant breast cancer is a major therapeutical challenge and accurate selection of patients susceptible to certain types of anti-hormonal treatment strategies is pivotal. Discovery of novel biomarkers potentially predicting treatment response as well as the clinical course of breast cancer is essential to effectively improve therapies and diagnosis. The main goal of this thesis was to
Cathepsin E (CTSE), an aspartic proteinase, is differentially expressed in the metaplasia-dysplasia-neoplasia sequence of gastric and colon cancer. We evaluated CTSE in Barrett's esophagus (BE) and cancer because increased CTSE levels are linked to improved survival in several cancers, and other cathepsins are up-regulated in BE and esophageal adenocarcinoma (EAC). A total of 273 pretreatment tiss
Objectives High-risk human papillomavirus (hrHPV) is the primary cause of cervical cancer. As Chlamydia trachomatis is also linked to cervical cancer, its role as a potential co-factor in the development of cervical intraepithelial neoplasia (CIN) grade 2 or higher was examined. Methods The placebo arms of two large, multinational, clinical trials of an HPV6/11/16/18 vaccine were combined. A total
BACKGROUND: Insulin resistance was found in some but not in all previous studies of non-diabetic first degree relatives of Type 2 diabetic patients. Small study groups, ethnic differences and/or non-optimal techniques may explain the conflicting results. AIM: To study the impact of a family history of Type 2 diabetes on insulin action in a large group of non-diabetic Europeans using the 'gold stan
OBJECTIVE— The purpose of this study was to assess the role of household conditions for the progression to diabetes in women with impaired glucose tolerance (IGT). RESEARCH DESIGN AND METHODS— A total of 461 women, aged 50–64 years, with IGT defined by an oral glucose tolerance test, had baseline advice on physical exercise, diet, smoking, and alcohol habits. Physical examination, blood tests, an
This Master Thesis successfully explains the difference in probability of default implied by Credit Default Swaps, traded by the market, and the benchmark Moody’s EDFTM. The difference is explained by the market price of risk, related to the Girsanov kernel, allowing us to transform the risk neutral measure Q to the physical measure P. This market price of risk is modeled with a log-linear multiva
In this study I present a theoretical model based on Marx´s critique of political economy, specific readings of Marx´s work and the regulation approach. This model will be used to explain long waves and cycles in long term economic growth, creative destruction (i.e the relation between technological leaps and economic crisis) and the ways in which these processes correspond to institutional develo
This paper describes how four teachers from the same school translate democracy from the curriculum. The interviews describes how the teachers work with the curriculum and what kind of difficulties they confront in the meeting with the students and other teachers. Through qualitative interviews of these teachers, have allowed us to read into their reflections as they explain their reality of the m
Calibration is an important _eld and is used everywhere from education, research and industry. Every electrical equipment has to be calibrated during manufacturing and even over time as it is worn down. The purpose of calibration is to come as close as possible to the true value. The question is how close is close enough and how close is possible? Because even the equipment used for calibration ne
In May 2009, a new Swedish legislation made it possible for a new tenure to enter the housing market – condominiums. Since the law took effect, only a few condominiums have been built, mainly by minor construction- and property companies. This thesis aims to investigate under what circums- tances it’s favorably to build condominiums and also to identify what ob- stacles and opportunities that c
The aim of this essay is to explore cyberbullying and online hate in games with a focus on how the game developers attempt to self-regulate this hate. With the Swedish laws not being in place to protect the victims and sanctioning the offenders this aspect is a clear example of in-formal control. The essay used Barry Zimmerman’s theory about self-regulation. The empirical part of this essay consis
Osteoarthritis and osteoporosis are two medical conditions involving the hip which affect the life quality of many people worldwide. These two diseases are diagnosed with 2D imaging by analysis of radiological measures, bone mineral density and joint space. Computed Tomography (CT) can provide 3D images of the hip, but has higher cost and imposes a higher radiation dose to the patient. Another op
Politics should be constituted by social representativeness in order to be conceptualised as democratic and legitimate. The set of politicians ought to be diverse and heterogeneous with the aim to include a wide spectrum of interest and concerns. The debate about women lacking power in politics was raised in the seventies. The political parties acted in response to the debate by implementing diffe
Connecting science to political agenda-setting is essential for a sustainable transition and acceptable politics. This task is complicated by phenomena like post-truth, for which facts are a non-issue. However, post-truth is not the only issue. The practice of political spin, in which the significance of facts is reconstructed according to specific interests poses another threat to scientific cred
The green bond market has seen exponential growth since its boom in 2013 but literature on this topic is considered woefully inadequate. This research paper therefore seeks to compare the performance of European green bonds against its conventional counterparts. Analysis was conducted on two data samples spanning from the year 2013 to 2019 using the matching principle and an extended Fama-French m
Reducing microorganisms by UV light is has been commonly used for drinking water for many years. In other liquid products like apple juice it is a rather novel application. The advantages would be that quality parameters like aromas and vitamins are less affected by the UV treatment compared to a heat treatment. Furthermore it would probably be cheaper, as the lamps need less electrical energy tha
