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In addition to its role in neuronal survival, the brain neurotrophic factor (BDNF) has been shown to influence serotonin transmission and synaptic plasticity, events strongly implicated in the appearance of L-DOPA-induced dyskinesia (LID), a motor complication occurring in parkinsonian patients after long-term treatment with the dopamine precursor. In order to evaluate a possible influence of BDNF
The development of genetic counseling in Sweden in the field of medical genetics emerged in the 1950s, at the department of medical genetics at Uppsala University. The head of department, Jan Arvid Böök, a member of the WHO expert committee on Human Genetics, early realized the importance of studies in broadly distributed genetic diseases, along with genetic counseling. In the 1950s, at the same tThe development of genetic counseling in Sweden in the field of medical genetics emerged in the 1950s, at the department of medical genetics at Uppsala University. The head of department, Jan Arvid Böök, a member of the WHO expert committee on Human Genetics, early realized the importance of studies in broadly distributed genetic diseases, along with genetic counseling. In the 1950s, at the same t
1. Studies modelling heat transfer of bird plumage design suggest that insulative properties can be attributed to the density and structure of the downy layer, whereas waterproofing is the result of the outer layer, comprised of contour feathers. In this study, we test how habitat and thermal condition affect feather mass and density of body feathers (contour, semiplume and downy feathers) measure1.Studies modelling heat transfer of bird plumage design suggest that insulative properties can be attributed to the density and structure of the downy layer, whereas waterproofing is the result of the outer layer, comprised of contour feathers. In this study, we test how habitat and thermal condition affect feather mass and density of body feathers (contour, semiplume and downy feathers) measured
Type 2 diabetes is one of the world’s major challenges today. Over 400 million people around the globe are diagnosed with diabetes and the consequences to the individual patient and health care systems are significant. Diabetes is a chronic disease and the standard treatment including lifestyle changes, metformin and insulin is in many cases not effective enough. New anti-diabetic drugs have been Type 2 diabetes is one of the world’s major challenges today. Over 400 million people around the globe are diagnosed with diabetes and the consequences to the individual patient and health care systems are significant. Diabetes is a chronic disease and the standard treatment including lifestyle changes, metformin and insulin is in many cases not effective enough. New anti-diabetic drugs have been
This thesis consists of five papers within the design and analysis of efficient algorithms.In the first paper, we consider the problem of computing all-pairs shortest paths in a directed graph with real weights assigned to vertices. We develop a combinatorial randomized algorithm that runs in subcubic time for a special class of graphs.In the second paper, we present a polynomial-time dynamic prog
Epilepsy is a neurological disorder with a prevalence of ≈1% of general population. Available antiepileptic drugs (AEDs) have multiple side effects and are ineffective in 30% of patients. Therefore, development of effective treatment strategies is highly needed, requiring drug-screening models that are relevant and reliable. We investigated novel chemogenetic approach, using DREADDs (designer rece
Chloride anations of PtCl5H2O−, trans-PtCl4(H2O)2 and trans-Pt(CN)4ClH2O− in the presence of PtCl42− have been studied at 50°C in 1.00M perchloric acid medium. It is shown that PtCl5H2O− is formed as the primary reaction product in the two last-mentioned anations. This is not compatible with the generally used mechanism for platinum(II)-catalyzed platinum (IV) substitutions, which gives PtCl62− asChloride anations of PtCl5H2O−, trans-PtCl4(H2O)2 and trans-Pt(CN)4ClH2O− in the presence of PtCl42− have been studied at 50°C in 1.00M perchloric acid medium. It is shown that PtCl5H2O− is formed as the primary reaction product in the two last-mentioned anations. This is not compatible with the generally used mechanism for platinum(II)-catalyzed platinum (IV) substitutions, which gives PtCl62− as
INTRODUCTION: Hypertension and dyslipidemia often precede cardiovascular disease. Lifestyle modifications help prevent these conditions, and referrals for women may be possible during reproductive health care visits. However, screening recommendations vary, which may affect screening rates. The objectives of this systematic review were to 1) assess the available literature on the effectiveness of
A complex reaction mechanism of oxidation of the anti-tubercular prodrug isoniazid (isonicotinic hydrazide, INH) by [IrCl6]2− as a model for redox processes of such drugs in biological systems has been studied in aqueous solution as a function of pH between 0 and 8.5. Similar experiments have been performed with its isomer nicotinic hydrazide (NH). All reactions are overall second-order, first-ordA complex reaction mechanism of oxidation of the anti-tubercular prodrug isoniazid (isonicotinic hydrazide, INH) by [IrCl6]2− as a model for redox processes of such drugs in biological systems has been studied in aqueous solution as a function of pH between 0 and 8.5. Similar experiments have been performed with its isomer nicotinic hydrazide (NH). All reactions are overall second-order, first-ord
A search for Higgs boson decays into a Z boson and a light resonance in two-lepton plus jet events is performed, using a pp collision dataset with an integrated luminosity of 139 fb-1 collected at s=13 TeV by the ATLAS experiment at the CERN LHC. The resonance considered is a light boson with a mass below 4 GeV from a possible extended scalar sector or a charmonium state. Multivariate discriminant
The objective of this study was to review and describe the current state of Swedish osteoporosis care and to highlight ongoing challenges. This report encompasses quantitative health outcomes based on Swedish registry data as well as organizational and management aspects. Swedish osteoporosis care is characterized by a significant burden of disease, difficulties in identifying high-risk patients,
Children’s biographies are only rarely and more recently considered. In this paper, we make a case for thinking biographically about children’s relational lives. Using two qualitative case studies from research with children in middle childhood, in the UK and Sweden, we attend to the materiality of children’s biographies. We explore the way in which home spaces, possessions, family mementoes and m
The density of roots is an important factor influencing the rate and magnitude of landslides. Due to the increased variability in climate, mainly rainfall, Eastern Uganda is severely struck by an increasing number of these mass movements, often with human casualties as one of the negative impacts. The aim of this study is to explore the possibility to estimate the depth and density of the root sys
Objectives To assess the impact of extra-articular spondyloarthritis (SpA) manifestations (anterior uveitis, psoriasis and inflammatory bowel disease (IBD)), and of comorbidities, on tumour necrosis factor alpha inhibitor (TNFi) drug retention in ankylosing spondylitis (AS). Methods We identified all bio-naïve patients with AS starting a first ever TNFi July 2006 to December 2015 from the Swedish
BACKGROUND AND PURPOSE: Previous reports concerning sex-related differences in stroke management and outcome are inconsistent and are sometimes difficult to interpret. We used data from a national stroke register to further explore possible differences between men and women in baseline characteristics, stroke treatment, and outcome. METHODS: This study included 24 633 stroke events registered in R
Particle formation events were analysed from aerosol number size distribution data collected at a background station in southern Sweden between February 2001 and May 2004. Events occurred on about 36% of all days and were favoured by high global radiation values. The clearest events (class I, 20% of all days) were observed when the formation rate of activated hypothetical clusters around 1 nm diam
Denna studie syftade till hur framing-effekten påverkar minnesbilder och individers uppfattningar om en våldsam händelse, med fokus på ordningsvakters agerande. I en kvantitativ experimentell design fördelades försökspersonerna (n=63) slumpmässigt i två grupper, kontrollgrupp (n=30) och experimentell grupp (n=33). Experimentgruppen exponerades för ett negativt vinklat narrativ och kontrollgruppen The aim of this study was to investigate the influence of the framing effect on individuals’ perceptions and memory of a violent event, focusing specifically on the actions of security guards. In a quantitative experimental design, the participants (n=63) were assigned either a neutral (n=30) or a biased narrative (n=33) before watching a video of a group conflict. Participants were then asked to
Non-linear acoustic methods has shown increasing potential in the identication of damage in brittle materials such as concrete. Commonly, these methods focus on one or several resonance frequencies of the material and on the relative change in resonance frequency and attenuation with strain amplitude which has been shown to allow one to identify the extent of the material damage. However, current
Det har aldrig gjorts något samlat försök att systematisera sakrätten från lagstiftarens sida. Särskilt separationsrättsliga problem är beständiga över tiden. Uppfattningarna om rättsläget beträffande separationsrätt vid sammanblandad egendom går isär. Det är svårt att se tydliga mönster i rättstillämpningen och förutsägbarheten är begränsad. Generellt sätt är rättsläget oklart. Vi vet inte vilka Rights in rem have never been systematized by the Swedish legislator. Especially problems regarding separation rights are recurring. Views differ on the owner’s right to separate intermixed property in a debtor’s bankruptcy or execution. The legal position is uncertain and predictability is limited. Since there is no general principle of separation right in the event of intermixed property and cas
