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BACKGROUND: Tumor development requires angiogenesis, and antiangiogenesis has been introduced in the treatment of cancer patients; however, how the cardiovascular phenotype correlates with cancer risk remains ill-defined. Here, we hypothesized that vasoactive peptides previously implicated in angiogenesis regulation predict long-term cancer risk.METHODS: We measured midregional proatrial natriuret

BACKGROUND: The incidence of distal radius fracture has increased substantially during the last 50 years according to several studies that estimated the overall incidence in various general populations. The incidence of fracture classified according to severity has not been well documented. The aim of this population-based study was to estimate the overall and type-specific incidence rates of dist

Popular Abstract in Swedish Det har nu gått 20 år sedan ett utbrott av ledinflammation (arthrit), i Connecticut, USA, satte forskarna på spåret till den sjukdomsbild som vi idag kallar fästingöverförd borreliainfektion och det är snart 15 år sedan man lyckades isolera bakterien som orsakar sjukdomen, Borrelia burgdorferi. Symptomen på sjukdomen har visserligen varit kända sedan sekelskiftet men he

Objective: The concentration of the complex between activated protein C (APC) and protein C inhibitor (PCI) is a measure of thrombin generation. We studied whether it can provide information useful for the diagnosis and treatment of arterial vascular disease. Methods: Blood was obtained from 429 vascular patients admitted consecutively during September 2004 to March 2005. The APC-PCI complex was m

Purpose: To examine whether panretinal photocoagulation for severe non-proliferative retinopathy in type 1 diabetes patients could halt the progression of retinopathy with subsequent vitreous haemorrhages and visual impairment. Methods: During a 10-year follow-up study period of 344 type 1 diabetes patients, 81 subjects went through panretinal photocoagulation. Forty patients were treated for sev

This thesis outlines the design and construction of an acoustophoretic trapping device with greatly increased capacity and throughput, compared to current commercial systems. In acoustic trapping, a strong, localised acoustic field is generated inside a channel. This field can capture and retain particles against a flow, allowing for nanoparticle purification and enrichment without the need for ul

Lund's Climate Alliance was initiated 2010 by the municipality of Lund, in southern Sweden, to support local climate adaptation and mitigation efforts. The purpose of this paper is to investigate what each member of Lund's Climate Alliance believes will be necessary to realize sustainability goals particular to their organization in the future. The study thereby points to new topics, activ

Den 1 juni 2018 infördes ett frivillighetsrekvisit i den svenska våldtäktsbe-stämmelsen i 6 kap 1 § BrB. Det nya rekvisitet innebär att avsaknad av ömse-sidig frivillighet ligger till grund för straffansvar. Målsägandens agerande och hur personen uttryckt frivillighet är av central betydelse för bedömningen. I min uppsats har jag undersökt vilka gränser målsägandens frivillighet ställs inför när dOn June 1, 2018, a voluntariness requirement was introduced in the Swedish rape provision in Chapter 6, Section 1 of the Swedish Penal Code (BrB). The new requirement implies that the absence of mutual voluntariness forms the basis for criminal liability. The actions of the victim and how their expressed voluntariness is assessed are of central importance in the evaluation. In my essay, I have exa

Den 1 juli 2018 ändrades svensk sexualbrottslagstiftning i grunden då bedömningen för vad som utgör ett sexuellt övergrepp förändrades till att definieras utifrån huruvida deltagandet i sexuell kontakt sker frivilligt. Ändringarna som infördes i brottsbalken brukar gemensamt kallas samtyckeslagen. Förändringen innebar även att ett nytt brott, oaktsam våldtäkt som regleras i 6 kap. 1 a § brottIn July 2018, the Swedish legislation regarding sexual assault fundamentally changed in terms of which criminal acts are considered to be a violation of the law. Among these changes was the implementation of the new criminal offence of negligent rape, found in the sixth chapter of the Swedish penal code, which opposedly to the previous ruling that only included intentional acts, now criminali

Idag är könsdiskriminerande reklam inte förbjudet i Sverige. Marknadsdomstolen har fastslagit att den typen av reklam inte faller under MFL:s tillämpningsområde. Istället sköts tillsynen av stiftelsen RO som fungerar som näringslivets självreglering. Huruvida könsdiskriminerande reklam bör förbjudas i lag eller inte har varit uppe för diskussion vid ett flertal tillfällen. Flera utredningar har Today, sexist advertisement is not illegal in Sweden. MD has decided that MFL is not applicable on that kind of advertising. Instead, the industry regulates itself through the RO foundations supervision. They use certain criteria established by the ICC and ERK to determine whether advertisement is sexist or not. Although, this system might be seen as ineffective since RO has no right to issue sanc

Popular summary The fate of non-steroidal anti-inflammatory drugs The knowledge about distribution of drugs between sewage sludge, water phases and water living organisms is vital for predictions of the fate and transport routes of toxic substances to the environment. And the distribution of drugs in the environment can be used as a base for risk assessments and it also can be used to define desir

Populärvetenskaplig sammanfattning: Är klimatforskningen skev? En central fråga är om vi kan lita på att vetenskapliga tidskrifter återger en rättvis bild av aktuella forskningsresultat? Dessutom bör vi fråga oss hur rapporteringen påverkas då betydande händelser sker inom vetenskapsvärlden. I november 2007 och senare 2009 skedde två viktiga företeelser inom klimatforskningen som potentiellt kanAbstract The declaration of a scientific consensus concerning anthropogenic causes for climate change by the IPCC in their fourth assessment report (AR4), published in 2007, initiated a heated debate. During this debate, experts within the IPCC were accused of selective reporting and the AR4 got strong source criticism by politicians, stakeholders and climate skeptics in general. The debate furth

Den svenska arvsrätten kännetecknas av sega strukturer och långsamma förändringar. Reglerna har inte varit föremål för någon omfattande reform sedan början av 1900-talet. Nuvarande lagstiftning präglas därför av inslag från gamla normer och strukturer. Dessa gamla normer och strukturer utmanas och debatteras idag flitigt såväl i media som i de politiska organen. Den här framställningen belyser denThe Swedish succession law is characterized by strong structures and slow changes. The legislation has not been subject of any major reform since the beginning of the 20th century. Therefore, the current legislation is characterized by elements of old norms and structures. These old norms and structures are challenged and debated today, both in the media and in political bodies. This thesis highli

Unconscionability är en grund för jämkning eller ogiltigförklaring av avtal som typiskt sett används vid en kombination av oskäliga avtalsvillkor och brister i själva avtalssituationen. Regeln har sitt ursprung huvudsakligen i den engelska rättens equity och kan där spåras till åtminstone 1400-talet. Unconscionability blev en del av amerikansk avtalsrätt genom införandet av engelsk rätt i de nybilUnconscionability is a contract defense typically advanced in cases in which there is a combination of unfair contract terms and deficient bargaining. Its origin is primarily in equity as practiced in England, where the doctrine can be traced back to at least the fifteenth century. Unconscionability entered American contract law through the adoption of English law in the former colonies. The conce

In Sweden as well as in The Netherlands energy policy is increasingly aiming at extending the use of renewable sources. In accordance with the targets of the European Union, both countries have formulated national targets for the year 2020. For wind energy these targets are 30.0 TWh of electricity in Sweden and a total installed capacity of 10.0 GW in The Netherlands. Wind is an inflexible, variab

BACKGROUND: Previous studies showed higher early mortality rates among patients treated with antiretroviral drugs in settings with limited resources. One of the reasons was late presentation of patients to care. With improved access to HIV services, we expect improvements in disease stage at presentation. Our objective was to assess the effect of improved availability of HIV services on patient pr

Objective: Investigate all-cause and cause-specific late mortality after childhood acute lymphoblastic leukemia (ALL) in a population-based Nordic cohort. Methods: From the cancer registries of Denmark, Finland, and Sweden, we identified 3765 five-year survivors of ALL, diagnosed before age 20 during 1971–2008. For each survivor, up to five matched comparison subjects were randomly selected from t

AIM/HYPOTHESIS: Five subgroups were described in European diabetes patients using a data driven machine learning approach on commonly measured variables. We aimed to test the applicability of this phenotyping in Indian individuals with young-onset type 2 diabetes.METHODS: We applied the European-derived centroids to Indian individuals with type 2 diabetes diagnosed before 45 years of age from the